Aliases for TMEM61 Gene

Aliases for TMEM61 Gene

  • Transmembrane Protein 61 2 3 4 5
  • TMEM61 5

External Ids for TMEM61 Gene

Previous GeneCards Identifiers for TMEM61 Gene

  • GC01P055159
  • GC01P055446
  • GC01P053560

Summaries for TMEM61 Gene

GeneCards Summary for TMEM61 Gene

TMEM61 (Transmembrane Protein 61) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM61 Gene

Genomics for TMEM61 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054882 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 260.7 -94.4 -94378 7.9 BCLAF1 SP1 ZNF207 MYC ZNF600 IKZF1 SSRP1 ZMYM3 KLF9 POLR2A DHCR24-DT DHCR24 TMEM61 ENSG00000242396 SSBP3-AS1 LRRC42 HSPB11 CYB5RL ENSG00000279049 TTC22
GH01J054980 Promoter 0.9 EPDnew Ensembl 263.8 +0.2 187 1.2 ZFX KDM1A EZH2 TMEM61 HSALNG0003811 LOC105378736 ENSG00000233271 BSND
GH01J054979 Enhancer 0.3 FANTOM5 277.7 -0.6 -649 0.1 EZH2 TMEM61 HSALNG0003811 LOC105378736 LEXM HSALNG0003810 DHCR24
GH01J054953 Enhancer 1.1 FANTOM5 Ensembl ENCODE 25.8 -26.0 -25963 3.5 MAX RAD51 FOXA2 SAP130 USF2 FOSL2 JUND CBX1 ELF3 L3MBTL2 TMEM61 TRK-CTT7-1 piR-48857 HSALNG0003806-001 DHCR24
GH01J054949 Enhancer 1 ENCODE CraniofacialAtlas 24.6 -29.8 -29796 1.4 BCLAF1 ZNF654 CEBPA POLR2A NFIC YY1 CTCF CEBPB REST TRIM22 TMEM61 piR-48857 TRK-CTT7-1 HSALNG0003806-001 DHCR24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM61 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM61

Top Transcription factor binding sites by QIAGEN in the TMEM61 gene promoter:
  • c-Myc
  • COMP1
  • E47
  • HNF-4alpha1
  • HNF-4alpha2
  • LCR-F1
  • Max1
  • Pax-2
  • Pax-2a
  • Tal-1

Genomic Locations for TMEM61 Gene

Latest Assembly
chr1:54,980,614-54,992,293
(GRCh38/hg38)
Size:
11,680 bases
Orientation:
Plus strand

Previous Assembly
chr1:55,446,301-55,457,961
(GRCh37/hg19 by Entrez Gene)
Size:
11,661 bases
Orientation:
Plus strand

chr1:55,446,465-55,457,966
(GRCh37/hg19 by Ensembl)
Size:
11,502 bases
Orientation:
Plus strand

Genomic View for TMEM61 Gene

Genes around TMEM61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM61 Gene

Proteins for TMEM61 Gene

  • Protein details for TMEM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U2-TMM61_HUMAN
    Recommended name:
    Transmembrane protein 61
    Protein Accession:
    Q8N0U2

    Protein attributes for TMEM61 Gene

    Size:
    210 amino acids
    Molecular mass:
    22170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM61 Gene

Post-translational modifications for TMEM61 Gene

No Post-translational modifications

Other Protein References for TMEM61 Gene

No data available for DME Specific Peptides for TMEM61 Gene

Domains & Families for TMEM61 Gene

Gene Families for TMEM61 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM61 Gene

InterPro:

Suggested Antigen Peptide Sequences for TMEM61 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 61 (TMM61_HUMAN)
genes like me logo Genes that share domains with TMEM61: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM61 Gene

Function for TMEM61 Gene

Phenotypes From GWAS Catalog for TMEM61 Gene

Gene Ontology (GO) - Molecular Function for TMEM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with TMEM61: view
genes like me logo Genes that share phenotypes with TMEM61: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM61

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM61 Gene

Localization for TMEM61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM61 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM61 gene
Compartment Confidence
plasma membrane 2
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM61: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM61 Gene

Pathways & Interactions for TMEM61 Gene

PathCards logo

SuperPathways for TMEM61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM61 Gene

Drugs & Compounds for TMEM61 Gene

No Compound Related Data Available

Transcripts for TMEM61 Gene

mRNA/cDNA for TMEM61 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM61

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM61 Gene

No ASD Table

Relevant External Links for TMEM61 Gene

GeneLoc Exon Structure for
TMEM61

Expression for TMEM61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM61 Gene

This gene is overexpressed in Pituitary (x13.6) and Kidney - Cortex (x5.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM61

SOURCE GeneReport for Unigene cluster for TMEM61 Gene:

Hs.663950

Evidence on tissue expression from TISSUES for TMEM61 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with TMEM61: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM61 Gene

Orthologs for TMEM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM61 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM61 29 30
  • 97.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM61 29 30
  • 79.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM61 29 30
  • 76.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100909776 29
  • 66.67 (n)
Mouse
(Mus musculus)
Mammalia Tmem61 29 16
  • 66.67 (n)
Chicken
(Gallus gallus)
Aves TMEM61 29 30
  • 63.33 (n)
OneToOne
Species where no ortholog for TMEM61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMEM61 Gene

ENSEMBL:
Gene Tree for TMEM61 (if available)
TreeFam:
Gene Tree for TMEM61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM61: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM61

Paralogs for TMEM61 Gene

Pseudogenes.org Pseudogenes for TMEM61 Gene

genes like me logo Genes that share paralogs with TMEM61: view

No data available for Paralogs for TMEM61 Gene

Variants for TMEM61 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM61 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3737832 -- p.Glu40Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM61 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM61 Gene

Variant ID Type Subtype PubMed ID
dgv167n100 CNV gain 25217958
nsv817614 CNV gain 22305530
nsv829915 CNV gain 17160897

Variation tolerance for TMEM61 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM61
Leiden Open Variation Database (LOVD)
TMEM61

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM61 Gene

Disorders for TMEM61 Gene

Additional Disease Information for TMEM61

No disorders were found for TMEM61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM61 Gene

Publications for TMEM61 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3

Products for TMEM61 Gene

Sources for TMEM61 Gene