Aliases for TMEM60 Gene

Aliases for TMEM60 Gene

  • Transmembrane Protein 60 2 3 4 5
  • C7orf35 3 4
  • Chromosome 7 Open Reading Frame 35 2
  • DC32 3

External Ids for TMEM60 Gene

Previous HGNC Symbols for TMEM60 Gene

  • C7orf35

Previous GeneCards Identifiers for TMEM60 Gene

  • GC07M077068
  • GC07M077260
  • GC07M077423
  • GC07M072026

Summaries for TMEM60 Gene

GeneCards Summary for TMEM60 Gene

TMEM60 (Transmembrane Protein 60) is a Protein Coding gene. An important paralog of this gene is TMEM185B.

Additional gene information for TMEM60 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM60 Gene

Genomics for TMEM60 Gene

GeneHancer (GH) Regulatory Elements for TMEM60 Gene

Promoters and enhancers for TMEM60 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J077796 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 755.3 -0.4 -360 4.8 E2F8 SP1 ZBTB40 CTCF SREBF1 ZBTB6 RBPJ SMARCE1 POLR2A TCF7L2 TMEM60 PHTF2 RSBN1L SPDYE18 FAM185BP DTX2P1 PMS2P9 SPDYE17 APTR PTPN12
GH07J077694 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +101.6 101633 6 GTF3C2 SIN3A SP1 CTCF RBPJ SMARCE1 POLR2A NR2F1 ATF1 FOS RSBN1L APTR SPDYE18 FAM185BP DTX2P1 PMS2P9 SPDYE17 PTPN12 PHTF2 TMEM60
GH07J077905 Enhancer 0.8 Ensembl ENCODE 16.3 -108.5 -108467 3.4 ETV6 L3MBTL2 IKZF1 IKZF2 HDAC1 ZNF316 ZNF24 SOX6 DPF2 EED APTR TMEM60 PHTF2 RF00017-6407 ENSG00000222432 AC073520
GH07J077684 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 11 +112.1 112133 5 HLF MAX MNT IKZF1 ZNF629 ZNF316 SCRT2 ZBTB48 ZNF10 OSR2 APTR PTPN12 PHTF2 TMEM60 DTX2P1 lnc-RSBN1L-2 RSBN1L
GH07J077823 Enhancer 0.9 Ensembl ENCODE 12.9 -25.3 -25267 4.2 SMARCE1 TEAD4 CBFA2T2 SMARCA4 TRIM24 IKZF1 DPF2 ZNF24 EHMT2 ZBTB2 APTR PHTF2 TMEM60 PTPN12 lnc-RSBN1L-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM60 gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • E47
  • Evi-1
  • GATA-2
  • Hand1
  • MZF-1
  • Nkx2-5
  • p300
  • STAT5A

Genomic Locations for TMEM60 Gene

Genomic Locations for TMEM60 Gene
chr7:77,793,728-77,798,434
(GRCh38/hg38)
Size:
4,707 bases
Orientation:
Minus strand
chr7:77,423,045-77,427,897
(GRCh37/hg19)
Size:
4,853 bases
Orientation:
Minus strand

Genomic View for TMEM60 Gene

Genes around TMEM60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM60 Gene

Proteins for TMEM60 Gene

  • Protein details for TMEM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L4-TMM60_HUMAN
    Recommended name:
    Transmembrane protein 60
    Protein Accession:
    Q9H2L4
    Secondary Accessions:
    • A4D1C3
    • Q86UM0

    Protein attributes for TMEM60 Gene

    Size:
    133 amino acids
    Molecular mass:
    15500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65930.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM60 Gene

Post-translational modifications for TMEM60 Gene

No Post-translational modifications

Other Protein References for TMEM60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM60 Gene

Domains & Families for TMEM60 Gene

Gene Families for TMEM60 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM60 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 60 (TMM60_HUMAN)
genes like me logo Genes that share domains with TMEM60: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM60 Gene

Function for TMEM60 Gene

Phenotypes From GWAS Catalog for TMEM60 Gene

genes like me logo Genes that share phenotypes with TMEM60: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM60

CRISPR Products

miRNA for TMEM60 Gene

miRTarBase miRNAs that target TMEM60

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM60

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM60 Gene

Localization for TMEM60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM60 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM60 gene
Compartment Confidence
extracellular 2
plasma membrane 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TMEM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM60: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM60 Gene

Pathways & Interactions for TMEM60 Gene

PathCards logo

SuperPathways for TMEM60 Gene

No Data Available

Interacting Proteins for TMEM60 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000257663 Q9H2L4-TMM60_HUMAN for TMEM60 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM60 Gene

Drugs & Compounds for TMEM60 Gene

No Compound Related Data Available

Transcripts for TMEM60 Gene

mRNA/cDNA for TMEM60 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(121) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM60

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM60 Gene

No ASD Table

Relevant External Links for TMEM60 Gene

GeneLoc Exon Structure for
TMEM60
ECgene alternative splicing isoforms for
TMEM60

Expression for TMEM60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM60 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM60 Gene:

TMEM60

SOURCE GeneReport for Unigene cluster for TMEM60 Gene:

Hs.19025

Evidence on tissue expression from TISSUES for TMEM60 Gene

  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM60: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM60 Gene

Orthologs for TMEM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM60 33 32
  • 99.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM60 33 33
  • 98 (a)
OneToMany
LOC100295750 32
  • 96.74 (n)
dog
(Canis familiaris)
Mammalia TMEM60 33 32
  • 96.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem60 17 33 32
  • 94.74 (n)
rat
(Rattus norvegicus)
Mammalia Tmem60 32
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM60 33
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM60 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM60 33 32
  • 81.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM60 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem60 32
  • 76.77 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:91811 32
  • 67.17 (n)
Species where no ortholog for TMEM60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM60 Gene

ENSEMBL:
Gene Tree for TMEM60 (if available)
TreeFam:
Gene Tree for TMEM60 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM60: view image

Paralogs for TMEM60 Gene

Paralogs for TMEM60 Gene

genes like me logo Genes that share paralogs with TMEM60: view

Variants for TMEM60 Gene

Sequence variations from dbSNP and Humsavar for TMEM60 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000437122 -- 77,797,066(-) C/A intron_variant
rs1001528735 -- 77,793,445(-) T/C downstream_transcript_variant
rs1002109094 -- 77,798,689(-) C/T upstream_transcript_variant
rs1002131340 -- 77,795,473(-) C/T intron_variant
rs1002526919 -- 77,795,093(-) G/A intron_variant

Variation tolerance for TMEM60 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM60 Gene

Disorders for TMEM60 Gene

Additional Disease Information for TMEM60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM60 Gene

Publications for TMEM60 Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 43 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 56
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 56
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 56

Products for TMEM60 Gene

Sources for TMEM60 Gene