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Aliases for TMEM60 Gene

Aliases for TMEM60 Gene

  • Transmembrane Protein 60 2 3 5
  • C7orf35 3 4
  • Chromosome 7 Open Reading Frame 35 2
  • DC32 3

External Ids for TMEM60 Gene

Previous HGNC Symbols for TMEM60 Gene

  • C7orf35

Previous GeneCards Identifiers for TMEM60 Gene

  • GC07M077068
  • GC07M077260
  • GC07M077423
  • GC07M072026

Summaries for TMEM60 Gene

GeneCards Summary for TMEM60 Gene

TMEM60 (Transmembrane Protein 60) is a Protein Coding gene.

Additional gene information for TMEM60 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM60 Gene

Genomics for TMEM60 Gene

GeneHancer (GH) Regulatory Elements for TMEM60 Gene

Promoters and enhancers for TMEM60 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I077796 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 555.5 -0.3 -346 4.5 HDGF FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TMEM60 PHTF2 RSBN1L SPDYE18 FAM185BP SPDYE17 APTR PMS2P9 LOC100422695 CCDC146
GH07I077694 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.2 +101.5 101491 5.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 APTR RSBN1L SPDYE18 TMEM60 SPDYE17 PHTF2 FAM185BP PMS2P9 DTX2P1 PTPN12
GH07I077833 Enhancer 1.1 Ensembl ENCODE 11.8 -36.0 -35952 2.2 ATF1 PKNOX1 CLOCK FOXA2 ARNT SIN3A NCOA2 ZNF766 GATA2 FOS PTPN12 PHTF2 TMEM60 APTR GC07P077851
GH07I077866 Enhancer 1 Ensembl ENCODE 11.3 -68.6 -68631 2.1 FOXA2 SIN3A ZNF366 ATF7 FOS MIXL1 USF2 CEBPB NFIL3 MAFF APTR PTPN12 PHTF2 TMEM60 GC07P077851 GC07P077896
GH07I077759 Enhancer 0.9 Ensembl ENCODE 11.7 +39.0 38988 0.8 CTCF ARID4B CEBPG RAD21 RFX5 CC2D1A ZNF316 FOXK2 ARID2 ZNF143 APTR RSBN1L TMEM60 PHTF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM60 gene promoter:

Genomic Locations for TMEM60 Gene

Genomic Locations for TMEM60 Gene
chr7:77,793,728-77,798,580
(GRCh38/hg38)
Size:
4,853 bases
Orientation:
Minus strand
chr7:77,423,045-77,427,897
(GRCh37/hg19)

Genomic View for TMEM60 Gene

Genes around TMEM60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM60 Gene

Proteins for TMEM60 Gene

  • Protein details for TMEM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L4-TMM60_HUMAN
    Recommended name:
    Transmembrane protein 60
    Protein Accession:
    Q9H2L4
    Secondary Accessions:
    • A4D1C3
    • Q86UM0

    Protein attributes for TMEM60 Gene

    Size:
    133 amino acids
    Molecular mass:
    15500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65930.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM60 Gene

Post-translational modifications for TMEM60 Gene

No Post-translational modifications

Other Protein References for TMEM60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM60 Gene

Domains & Families for TMEM60 Gene

Gene Families for TMEM60 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM60: view

No data available for UniProtKB/Swiss-Prot for TMEM60 Gene

Function for TMEM60 Gene

Phenotypes From GWAS Catalog for TMEM60 Gene

genes like me logo Genes that share phenotypes with TMEM60: view

Animal Model Products

miRNA for TMEM60 Gene

miRTarBase miRNAs that target TMEM60

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM60 Gene

Localization for TMEM60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM60 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM60 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM60: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM60 Gene

Pathways & Interactions for TMEM60 Gene

SuperPathways for TMEM60 Gene

No Data Available

Interacting Proteins for TMEM60 Gene

Selected Interacting proteins: Q9H2L4-TMM60_HUMAN for TMEM60 Gene via IID

Symbol External ID(s) Details
SSTR5

Gene Ontology (GO) - Biological Process for TMEM60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM60 Gene

Drugs & Compounds for TMEM60 Gene

No Compound Related Data Available

Transcripts for TMEM60 Gene

mRNA/cDNA for TMEM60 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(121) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM60 Gene

Transmembrane protein 60:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM60 Gene

No ASD Table

Relevant External Links for TMEM60 Gene

GeneLoc Exon Structure for
TMEM60
ECgene alternative splicing isoforms for
TMEM60

Expression for TMEM60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM60 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM60 Gene:

TMEM60

SOURCE GeneReport for Unigene cluster for TMEM60 Gene:

Hs.19025

Evidence on tissue expression from TISSUES for TMEM60 Gene

  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM60 Gene

Orthologs for TMEM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM60 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia TMEM60 34 34
  • 98 (a)
OneToMany
LOC100295750 33
  • 96.74 (n)
dog
(Canis familiaris)
Mammalia TMEM60 33 34
  • 96.49 (n)
mouse
(Mus musculus)
Mammalia Tmem60 33 16 34
  • 94.74 (n)
rat
(Rattus norvegicus)
Mammalia Tmem60 33
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM60 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM60 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM60 33 34
  • 81.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM60 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem60 33
  • 76.77 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:91811 33
  • 67.17 (n)
Species where no ortholog for TMEM60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM60 Gene

ENSEMBL:
Gene Tree for TMEM60 (if available)
TreeFam:
Gene Tree for TMEM60 (if available)

Paralogs for TMEM60 Gene

No data available for Paralogs for TMEM60 Gene

Variants for TMEM60 Gene

Sequence variations from dbSNP and Humsavar for TMEM60 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000437122 -- 77,797,066(-) C/A intron_variant
rs1001528735 -- 77,793,445(-) T/C downstream_transcript_variant
rs1002109094 -- 77,798,689(-) C/T upstream_transcript_variant
rs1002131340 -- 77,795,473(-) C/T intron_variant
rs1002526919 -- 77,795,093(-) G/A intron_variant

Variation tolerance for TMEM60 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM60 Gene

Disorders for TMEM60 Gene

Additional Disease Information for TMEM60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM60 Gene

Publications for TMEM60 Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for TMEM60 Gene

Sources for TMEM60 Gene

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