This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008] See more...

Aliases for TMEM59L Gene

Aliases for TMEM59L Gene

  • Transmembrane Protein 59 Like 2 3 5
  • BSMAP 2 3 4
  • Brain-Specific Membrane-Anchored Protein 3 4
  • Transmembrane Protein 59-Like 3 4
  • C19orf4 3 4
  • Chromosome 19 Open Reading Frame 4 2
  • TMEM59L 5

External Ids for TMEM59L Gene

Previous HGNC Symbols for TMEM59L Gene

  • C19orf4

Previous GeneCards Identifiers for TMEM59L Gene

  • GC19P018585
  • GC19P018723
  • GC19P018286
  • GC19P018725

Summaries for TMEM59L Gene

Entrez Gene Summary for TMEM59L Gene

  • This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM59L Gene

TMEM59L (Transmembrane Protein 59 Like) is a Protein Coding gene. An important paralog of this gene is TMEM59.

UniProtKB/Swiss-Prot Summary for TMEM59L Gene

  • Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM59L Gene

Genomics for TMEM59L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM59L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM59L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM59L

Top Transcription factor binding sites by QIAGEN in the TMEM59L gene promoter:
  • AP-4
  • c-Ets-1
  • c-Myb
  • Cart-1
  • MyoD
  • Pax-5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for TMEM59L Gene

Latest Assembly
chr19:18,607,430-18,621,040
(GRCh38/hg38)
Size:
13,611 bases
Orientation:
Plus strand

Previous Assembly
chr19:18,723,680-18,731,849
(GRCh37/hg19 by Entrez Gene)
Size:
8,170 bases
Orientation:
Plus strand

chr19:18,718,240-18,731,849
(GRCh37/hg19 by Ensembl)
Size:
13,610 bases
Orientation:
Plus strand

Genomic View for TMEM59L Gene

Genes around TMEM59L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM59L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM59L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM59L Gene

Proteins for TMEM59L Gene

  • Protein details for TMEM59L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK28-TM59L_HUMAN
    Recommended name:
    Transmembrane protein 59-like
    Protein Accession:
    Q9UK28

    Protein attributes for TMEM59L Gene

    Size:
    342 amino acids
    Molecular mass:
    37619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM59L Gene

Post-translational modifications for TMEM59L Gene

  • Glycosylation at Asn97
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM59L Gene

No data available for DME Specific Peptides for TMEM59L Gene

Domains & Families for TMEM59L Gene

Gene Families for TMEM59L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM59L Gene

Suggested Antigen Peptide Sequences for TMEM59L Gene

GenScript: Design optimal peptide antigens:
  • Brain-specific membrane-anchored protein (TM59L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK28

UniProtKB/Swiss-Prot:

TM59L_HUMAN :
  • Belongs to the TMEM59 family.
Family:
  • Belongs to the TMEM59 family.
genes like me logo Genes that share domains with TMEM59L: view

Function for TMEM59L Gene

Molecular function for TMEM59L Gene

UniProtKB/Swiss-Prot Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

Phenotypes From GWAS Catalog for TMEM59L Gene

genes like me logo Genes that share phenotypes with TMEM59L: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM59L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM59L Gene

Localization for TMEM59L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM59L Gene

Golgi apparatus membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM59L gene
Compartment Confidence
golgi apparatus 3
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for TMEM59L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 10527841
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with TMEM59L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM59L Gene

Pathways & Interactions for TMEM59L Gene

PathCards logo

SuperPathways for TMEM59L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM59L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM59L Gene

Drugs & Compounds for TMEM59L Gene

No Compound Related Data Available

Transcripts for TMEM59L Gene

mRNA/cDNA for TMEM59L Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM59L

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM59L Gene

No ASD Table

Relevant External Links for TMEM59L Gene

GeneLoc Exon Structure for
TMEM59L

Expression for TMEM59L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM59L Gene

mRNA differential expression in normal tissues according to GTEx for TMEM59L Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Hypothalamus (x4.4), Brain - Hippocampus (x4.4), and Brain - Cerebellum (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM59L

SOURCE GeneReport for Unigene cluster for TMEM59L Gene:

Hs.329850

mRNA Expression by UniProt/SwissProt for TMEM59L Gene:

Q9UK28-TM59L_HUMAN
Tissue specificity: Expressed preferentially at high level in the brain.

Evidence on tissue expression from TISSUES for TMEM59L Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with TMEM59L: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM59L Gene

Orthologs for TMEM59L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM59L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM59L 29 30
  • 99.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM59L 29 30
  • 88.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM59L 29 30
  • 86.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem59l 29 16 30
  • 77.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem59l 29
  • 77.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM59L 30
  • 49 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM59L 30
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM59L 30
  • 40 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM59L 30
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tmem59l 30
  • 38 (a)
OneToOne
wufi68e12 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3043 30
  • 18 (a)
OneToMany
Species where no ortholog for TMEM59L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM59L Gene

ENSEMBL:
Gene Tree for TMEM59L (if available)
TreeFam:
Gene Tree for TMEM59L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM59L: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM59L

Paralogs for TMEM59L Gene

Paralogs for TMEM59L Gene

(1) SIMAP similar genes for TMEM59L Gene using alignment to 2 proteins:

  • TM59L_HUMAN
  • M0R134_HUMAN
genes like me logo Genes that share paralogs with TMEM59L: view

Variants for TMEM59L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM59L Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs149737784 Benign: not provided 18,616,076(+) C/T
NM_012109.3(TMEM59L):c.510C>T (p.Ser170=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM59L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM59L Gene

Variant ID Type Subtype PubMed ID
nsv833776 CNV loss 17160897
nsv952422 CNV deletion 24416366

Variation tolerance for TMEM59L Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM59L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM59L
Leiden Open Variation Database (LOVD)
TMEM59L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM59L Gene

Disorders for TMEM59L Gene

Additional Disease Information for TMEM59L

No disorders were found for TMEM59L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM59L Gene

Publications for TMEM59L Gene

  1. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. (PMID: 10527841) Elson GC … Gauchat JF (Biochemical and biophysical research communications 1999) 2 3 4
  2. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. (PMID: 27324899) Zheng Q … Zhang YW (Molecular neurobiology 2017) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. (PMID: 31753913) Kim JJ … Miller KM (Genes & development 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for TMEM59L Gene

Sources for TMEM59L Gene