Aliases for TMEM59 Gene
Aliases for TMEM59 Gene
External Ids for TMEM59 Gene
- HGNC: 1239
- Entrez Gene: 9528
- Ensembl: ENSG00000116209
- OMIM: 617084
- UniProtKB: Q9BXS4
Previous HGNC Symbols for TMEM59 Gene
- C1orf8
Previous GeneCards Identifiers for TMEM59 Gene
- GC01M054210
- GC01M054269
- GC01M054497
- GC01M052613
Summaries for TMEM59 Gene
-
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for TMEM59 Gene
TMEM59 (Transmembrane Protein 59) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase activity. An important paralog of this gene is TMEM59L.
UniProtKB/Swiss-Prot for TMEM59 Gene
-
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Additional gene information for TMEM59 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM59 Gene
Genomics for TMEM59 Gene
GeneHancer (GH) Regulatory Elements for TMEM59 Gene
Promoters and enhancers for TMEM59 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TMEM59 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TMEM59 gene promoter:
-
- Cdc5
- FOXL1
- Evi-1
- LCR-F1
- NF-kappaB1
- Spz1
- HNF-3beta
- IRF-7A
- STAT3
Regulatory Element Products
Genomic Locations for TMEM59 Gene
Genomic Locations for TMEM59 Gene
- chr1:54,026,681-54,053,504
- (GRCh38/hg38)
- Size:
- 26,824 bases
- Orientation:
- Minus strand
- chr1:54,497,347-54,519,177
- (GRCh37/hg19)
- Size:
- 21,831 bases
- Orientation:
- Minus strand
Genomic View for TMEM59 Gene
Genes around TMEM59 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p32.3 by Entrez Gene
- 1p32.3 by HGNC
- 1p32.3 by Ensembl
TMEM59 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM59 Gene
Proteins for TMEM59 Gene
-
Protein details for TMEM59 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXS4-TMM59_HUMAN
- Recommended name:
- Transmembrane protein 59
- Protein Accession:
- Q9BXS4
- B3KQL7
- O75393
- Q4VBP9
- Q5T705
- Q96KX7
Protein attributes for TMEM59 Gene
- Size:
- 323 amino acids
- Molecular mass:
- 36223 Da
- Quaternary structure:
-
- Interacts with ATG16L1 (via WD repeats).
- SequenceCaution:
-
- Sequence=AAC39890.1; Type=Frameshift; Positions=6; Evidence={ECO:0000305}; Sequence=AAH03106.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TMEM59 Gene
Post-translational modifications for TMEM59 Gene
- N-glycosylated.
- Glycosylation at posLast=9090
- Ubiquitination at isoforms=315, isoforms=302, and posLast=206206
- Modification sites at PhosphoSitePlus
Other Protein References for TMEM59 Gene
Antibody Products
- R&D Systems Antibodies for TMEM59 (TMEM59)
- Novus Biologicals Antibodies for TMEM59
- Invitrogen Antibodies for TMEM59
- GeneTex TMEM59 Antibody for TMEM59
-
Custom Antibody ServicesProSci Antibodies for TMEM59
Protein Products
-
OriGene Purified Proteins for TMEM59
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM59
- Origene Custom Protein Services for TMEM59
- antibodies-online: Search results for 8 available TMEM59 Proteins ranked by validation data
- Compare Top TMEM59 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TMEM59
Assay Products
No data available for DME Specific Peptides for TMEM59 Gene
Domains & Families for TMEM59 Gene
Gene Families for TMEM59 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TMEM59 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM59 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BXS4UniProtKB/Swiss-Prot:
TMM59_HUMAN :- The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.
- Belongs to the TMEM59 family.
- Domain:
-
- The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.
- Family:
-
- Belongs to the TMEM59 family.
Function for TMEM59 Gene
Molecular function for TMEM59 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Phenotypes From GWAS Catalog for TMEM59 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 23376921 |
Phenotypes for TMEM59 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TMEM59
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM59
-
CRISPR Products
-
OriGene CRISPR knockouts for TMEM59
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM59
- genomics-online: gRNA clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
- Applied Biological Materials CRISPR for TMEM59
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM59
- GenScript: Design CRISPR guide RNA sequences for TMEM59
miRNA for TMEM59 Gene
- miRTarBase miRNAs that target TMEM59
-
- hsa-mir-30a-5p (MIRT005138)
- hsa-mir-149-5p (MIRT045645)
- hsa-mir-1260b (MIRT052744)
- hsa-mir-142-3p (MIRT439429)
- hsa-mir-1200 (MIRT492053)
- hsa-mir-378a-5p (MIRT492054)
- hsa-mir-616-3p (MIRT492055)
- hsa-mir-6073 (MIRT492056)
- hsa-mir-3140-5p (MIRT492057)
- hsa-mir-584-3p (MIRT492058)
- hsa-mir-3974 (MIRT492059)
- hsa-mir-7852-3p (MIRT492060)
- hsa-mir-548m (MIRT492061)
- hsa-mir-550b-2-5p (MIRT520572)
- hsa-mir-6807-5p (MIRT520573)
- hsa-mir-7151-3p (MIRT520574)
- hsa-mir-5095 (MIRT520575)
- hsa-mir-550a-5p (MIRT520576)
- hsa-mir-550a-3-5p (MIRT520577)
- hsa-mir-1271-3p (MIRT520578)
- hsa-mir-8077 (MIRT520579)
- hsa-mir-661 (MIRT520580)
- hsa-mir-3116 (MIRT520581)
- hsa-mir-1254 (MIRT520582)
- hsa-mir-4252 (MIRT520583)
- hsa-mir-6889-3p (MIRT520584)
- hsa-mir-6504-5p (MIRT520585)
- hsa-mir-3064-5p (MIRT520586)
- hsa-mir-4438 (MIRT520587)
- hsa-mir-3680-3p (MIRT613946)
- hsa-mir-557 (MIRT613947)
- hsa-mir-507 (MIRT613948)
- hsa-mir-450b-5p (MIRT613949)
- hsa-mir-19b-2-5p (MIRT613950)
- hsa-mir-19b-1-5p (MIRT613951)
- hsa-mir-19a-5p (MIRT613952)
- hsa-mir-7160-5p (MIRT613953)
- hsa-mir-4663 (MIRT613954)
- hsa-mir-4711-5p (MIRT613955)
- hsa-mir-7112-3p (MIRT613956)
- hsa-mir-93-3p (MIRT613957)
- hsa-mir-6761-5p (MIRT613958)
- hsa-mir-4328 (MIRT613959)
- hsa-mir-4698 (MIRT613960)
- hsa-mir-8063 (MIRT613961)
- hsa-mir-383-5p (MIRT613962)
- hsa-mir-522-3p (MIRT613963)
- hsa-mir-224-3p (MIRT613964)
- hsa-mir-133a-3p (MIRT637224)
- hsa-mir-670-5p (MIRT637225)
- hsa-mir-4281 (MIRT637226)
- hsa-mir-591 (MIRT637227)
- hsa-mir-4319 (MIRT637228)
- hsa-mir-125b-5p (MIRT637229)
- hsa-mir-125a-5p (MIRT637230)
- hsa-mir-4732-3p (MIRT637231)
- hsa-mir-345-3p (MIRT637232)
- hsa-mir-6884-3p (MIRT637233)
- hsa-mir-548s (MIRT662986)
- hsa-mir-3926 (MIRT662987)
- hsa-mir-5189-3p (MIRT662988)
- hsa-mir-4786-5p (MIRT662989)
- hsa-mir-4299 (MIRT662990)
- hsa-mir-7162-3p (MIRT662991)
- hsa-mir-544b (MIRT662992)
- hsa-mir-4433a-3p (MIRT662993)
- hsa-mir-4459 (MIRT662994)
- hsa-mir-4768-3p (MIRT662995)
- hsa-mir-3622b-3p (MIRT662996)
- hsa-mir-3622a-3p (MIRT662997)
- hsa-mir-490-3p (MIRT662998)
- hsa-mir-4722-5p (MIRT662999)
- hsa-mir-6134 (MIRT663000)
- hsa-mir-6884-5p (MIRT663001)
- hsa-mir-485-5p (MIRT663002)
- hsa-mir-4257 (MIRT663003)
- hsa-mir-6847-5p (MIRT663004)
- hsa-mir-940 (MIRT663005)
- hsa-mir-6893-5p (MIRT663006)
- hsa-mir-6808-5p (MIRT663007)
- hsa-mir-665 (MIRT674695)
- hsa-mir-6771-5p (MIRT674696)
- hsa-mir-1827 (MIRT674697)
- hsa-mir-4649-3p (MIRT674698)
- hsa-mir-6746-5p (MIRT674699)
- hsa-mir-4478 (MIRT674700)
- hsa-mir-4419b (MIRT674701)
- hsa-mir-3929 (MIRT674702)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM59
- Browse OriGene Inhibitory RNA Products For TMEM59
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM59
- genomics-online: shRNA clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TMEM59
- VectorBuilder custom plasmid, inducible vectors for TMEM59
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM59
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM59
- Applied Biological Materials Clones for TMEM59
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TMEM59
Cell Line Products
-
Horizon Cell Lines for TMEM59
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM59 Gene
Localization for TMEM59 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM59 Gene
- Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. {ECO:0000269 PubMed:23376921}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| plasma membrane | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000137 | Golgi cis cisterna | IDA | 20427278 |
| GO:0000138 | Golgi trans cisterna | IDA | 20427278 |
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005764 | lysosome | IEA,IDA | 23376921 |
| GO:0005765 | lysosomal membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM59 Gene
Pathways & Interactions for TMEM59 Gene
No Data Available
Interacting Proteins for TMEM59 Gene
Selected Interacting proteins:
Q9BXS4-TMM59_HUMAN
ENSP00000234831
for TMEM59 Gene via
IID
STRING
MINT
UniProtKB
GPS-Prot Interaction Network for TMEM59
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0010508 | positive regulation of autophagy | IMP | 23376921 |
| GO:0010955 | negative regulation of protein processing | IDA | 20427278 |
| GO:0090285 | negative regulation of protein glycosylation in Golgi | IDA | 20427278 |
No data available for Pathways by source and SIGNOR curated interactions for TMEM59 Gene
Transcripts for TMEM59 Gene
mRNA/cDNA for TMEM59 Gene
- (8) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (945) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000234831 6691 bps (uc001cwp.4)
- ENST00000371337 600 bps (uc057gti.1)
- ENST00000371341 1116 bps (uc057gtc.1)
- ENST00000371344 2473 bps (uc057gtb.1)
- ENST00000371348 1911 bps (uc001cwo.4)
Unigene Clusters for TMEM59 Gene
- Transmembrane protein 59:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TMEM59
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM59
- genomics-online: gRNA clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
- Applied Biological Materials CRISPR for TMEM59
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM59
- GenScript: Design CRISPR guide RNA sequences for TMEM59
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM59
- Browse OriGene Inhibitory RNA Products For TMEM59
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM59
- genomics-online: shRNA clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TMEM59
- VectorBuilder custom plasmid, inducible vectors for TMEM59
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM59
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM59
- Applied Biological Materials Clones for TMEM59
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TMEM59
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
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| SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - |
| ExUns: | 10d | · | 10e | · | 10f |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
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| SP17: |
Expression for TMEM59 Gene
This gene is overexpressed in Bone (44.2) and Placenta (17.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM59 Gene
NURSA nuclear receptor signaling pathways regulating expression of TMEM59 Gene:
TMEM59SOURCE GeneReport for Unigene cluster for TMEM59 Gene:
Hs.523262Evidence on tissue expression from TISSUES for TMEM59 Gene
- Nervous system(5)
- Lung(4.8)
- Blood(4.4)
- Pancreas(3.9)
- Intestine(3.4)
- Kidney(3.2)
- Eye(3.1)
- Adrenal gland(2.6)
- Spleen(2.6)
- Liver(2.5)
- Lymph node(2.5)
- Stomach(2.4)
- Skin(2.2)
- Thyroid gland(2.2)
- Gall bladder(2.1)
- Heart(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TMEM59
-
OriGene qPCR primer pairs for TMEM59
- genomics-online: primer clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM59 Gene
Orthologs for TMEM59 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM59 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TMEM59 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TMEM59 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tmem59 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1310313 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMEM59 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TMEM59 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TMEM59 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem59 33 |
|
||
| Str.6280 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.29361 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem59 34 33 |
|
OneToOne | |
| Dr.5932 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3043 34 |
|
OneToMany |
- Species where no ortholog for TMEM59 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TMEM59 Gene
- ENSEMBL:
- Gene Tree for TMEM59 (if available)
- TreeFam:
- Gene Tree for TMEM59 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM59: view image
Paralogs for TMEM59 Gene
Variants for TMEM59 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000024454 | -- | 54,046,921(-) | A/G | intron_variant | |
| rs1000122576 | -- | 54,032,287(-) | C/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1000235823 | -- | 54,051,805(-) | T/C | intron_variant | |
| rs1000259021 | -- | 54,045,401(-) | A/G | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000364078 | -- | 54,045,239(-) | T/A/C | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv477511 | CNV | novel sequence insertion | 20440878 |
| nsv475372 | CNV | novel sequence insertion | 20440878 |
| nsv1011262 | CNV | gain | 25217958 |
| nsv1003904 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.76;
33.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM59 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM59
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM59 Gene
Disorders for TMEM59 Gene
Additional Disease Information for TMEM59
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TMEM59 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM59 Gene
Publications for TMEM59 Gene
- TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. (PMID: 23376921) Boada-Romero E … Pimentel-Muiños FX (The EMBO journal 2013) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. (PMID: 20427278) Ullrich S … Lichtenthaler SF (The Journal of biological chemistry 2010) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
Products for TMEM59 Gene
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- Taconic Biosciences Mouse Models for TMEM59
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 29 available TMEM59 Antibodies ranked by validation data
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- antibodies-online: Search results for available TMEM59 related products ranked by validation data
- antibodies-online: Search results for 8 available TMEM59 Proteins ranked by validation data
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- Quality Products:
- GeneTex TMEM59 Antibody for TMEM59
- Search GeneTex for Proteins for TMEM59
- Custom Antibody ServicesProSci Antibodies for TMEM59
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- Horizon Cell Lines for TMEM59
- genomics-online: cdna clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
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- Overview of 155 available TMEM59 gene related products
- genomics-online: shRNA clones - Search results for 155 available TMEM59 gene related products
- Overview of 155 available TMEM59 gene related products
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Sources for TMEM59 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt