Aliases for TMEM59 Gene
External Ids for TMEM59 Gene
Previous HGNC Symbols for TMEM59 Gene
Previous GeneCards Identifiers for TMEM59 Gene
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for TMEM59 Gene
TMEM59 (Transmembrane Protein 59) is a Protein Coding gene. Diseases associated with TMEM59 include Estrogen Resistance and Deafness, Autosomal Recessive 68. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase activity. An important paralog of this gene is TMEM59L.
UniProtKB/Swiss-Prot Summary for TMEM59 Gene
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).