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Aliases for TMEM52 Gene

Aliases for TMEM52 Gene

  • Transmembrane Protein 52 2 3 5

External Ids for TMEM52 Gene

Previous GeneCards Identifiers for TMEM52 Gene

  • GC01M001882
  • GC01M001838
  • GC01M001126

Summaries for TMEM52 Gene

GeneCards Summary for TMEM52 Gene

TMEM52 (Transmembrane Protein 52) is a Protein Coding gene.

Additional gene information for TMEM52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM52 Gene

Genomics for TMEM52 Gene

GeneHancer (GH) Regulatory Elements for TMEM52 Gene

Promoters and enhancers for TMEM52 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001913 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 571.2 +1.7 1727 7.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 SP3 SP5 TMEM52 LOC105378949 CALML6 CFAP74 LOC105378589 GABRD
GH01I001775 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18 +139.8 139775 8.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 NADK INTS11 ENSG00000240731 CCNL2 CDK11A LOC100288379 LOC105378949 SDF4 ENSG00000230092 ATAD3B
GH01I001942 Enhancer 1.2 Ensembl ENCODE 31.2 -24.3 -24260 2.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 KLF13 SP5 TMEM52 LOC105378949 CALML6 MORN1 FAAP20 ATAD3B INTS11 LOC100129534 LINC01786 ENSG00000234396
GH01I001763 Enhancer 1.2 Ensembl ENCODE dbSUPER 28.9 +154.8 154784 1.8 FOXA2 PKNOX1 CLOCK NFIB SIN3A RAD21 YY1 HCFC1 RXRA CEBPB GC01P001764 PIR60981 TMEM52 CALML6 CDK11B ANKRD65 GC01P001762 NADK
GH01I001888 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12 +26.3 26292 9.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 GC01M001889 GNB1 LOC105378949 ATAD3B CCNL2 CALML6 FAAP20 INTS11 ENSG00000234396 ENSG00000240731
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM52 gene promoter:

Genomic Locations for TMEM52 Gene

Genomic Locations for TMEM52 Gene
chr1:1,917,589-1,919,301
(GRCh38/hg38)
Size:
1,713 bases
Orientation:
Minus strand
chr1:1,849,029-1,850,740
(GRCh37/hg19)

Genomic View for TMEM52 Gene

Genes around TMEM52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM52 Gene

Proteins for TMEM52 Gene

  • Protein details for TMEM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDY8-TMM52_HUMAN
    Recommended name:
    Transmembrane protein 52
    Protein Accession:
    Q8NDY8
    Secondary Accessions:
    • Q4VXS6
    • Q6UX25

    Protein attributes for TMEM52 Gene

    Size:
    209 amino acids
    Molecular mass:
    22122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM52 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM52 Gene

Post-translational modifications for TMEM52 Gene

No Post-translational modifications

Other Protein References for TMEM52 Gene

No data available for DME Specific Peptides for TMEM52 Gene

Domains & Families for TMEM52 Gene

Gene Families for TMEM52 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM52 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM52: view

No data available for UniProtKB/Swiss-Prot for TMEM52 Gene

Function for TMEM52 Gene

Phenotypes From GWAS Catalog for TMEM52 Gene

Phenotypes for TMEM52 Gene

GenomeRNAi human phenotypes for TMEM52:
genes like me logo Genes that share phenotypes with TMEM52: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM52 Gene

Localization for TMEM52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM52 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM52 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM52: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM52 Gene

Pathways & Interactions for TMEM52 Gene

SuperPathways for TMEM52 Gene

No Data Available

Interacting Proteins for TMEM52 Gene

Gene Ontology (GO) - Biological Process for TMEM52 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM52 Gene

Drugs & Compounds for TMEM52 Gene

No Compound Related Data Available

Transcripts for TMEM52 Gene

mRNA/cDNA for TMEM52 Gene

Unigene Clusters for TMEM52 Gene

Transmembrane protein 52:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM52 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for TMEM52 Gene

GeneLoc Exon Structure for
TMEM52
ECgene alternative splicing isoforms for
TMEM52

Expression for TMEM52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM52 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM52 Gene

This gene is overexpressed in Pancreas (x18.9), Muscle - Skeletal (x16.8), and Adrenal Gland (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM52 Gene:

TMEM52

SOURCE GeneReport for Unigene cluster for TMEM52 Gene:

Hs.123423

Evidence on tissue expression from TISSUES for TMEM52 Gene

  • Muscle(4.2)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with TMEM52: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM52 Gene

Orthologs for TMEM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM52 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia TMEM52 33 34
  • 88.19 (n)
cow
(Bos Taurus)
Mammalia TMEM52 33 34
  • 83.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem52 33
  • 81.48 (n)
mouse
(Mus musculus)
Mammalia Tmem52 33 16 34
  • 80.57 (n)
chicken
(Gallus gallus)
Aves TMEM52 34
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM52 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6433 33
Species where no ortholog for TMEM52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM52 Gene

ENSEMBL:
Gene Tree for TMEM52 (if available)
TreeFam:
Gene Tree for TMEM52 (if available)

Paralogs for TMEM52 Gene

No data available for Paralogs for TMEM52 Gene

Variants for TMEM52 Gene

Sequence variations from dbSNP and Humsavar for TMEM52 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000089090 -- 1,919,967(-) T/C upstream_transcript_variant
rs1000141350 -- 1,920,183(-) G/A upstream_transcript_variant
rs1000881139 -- 1,918,708(-) C/G/T intron_variant
rs1001147704 -- 1,919,396(-) G/A upstream_transcript_variant
rs1001165328 -- 1,917,354(-) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM52 Gene

Variant ID Type Subtype PubMed ID
esv2758913 CNV gain+loss 17122850
nsv10383 CNV gain 18304495
nsv482937 CNV loss 15286789
nsv834335 CNV loss 17160897
nsv951400 CNV deletion 24416366

Variation tolerance for TMEM52 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.63; 97.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM52 Gene

Disorders for TMEM52 Gene

Additional Disease Information for TMEM52

No disorders were found for TMEM52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM52 Gene

Publications for TMEM52 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for TMEM52 Gene

Sources for TMEM52 Gene

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