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Aliases for TMEM45B Gene

Aliases for TMEM45B Gene

  • Transmembrane Protein 45B 2 3 5

External Ids for TMEM45B Gene

Previous GeneCards Identifiers for TMEM45B Gene

  • GC11P129191
  • GC11P129688
  • GC11P125638

Summaries for TMEM45B Gene

GeneCards Summary for TMEM45B Gene

TMEM45B (Transmembrane Protein 45B) is a Protein Coding gene. An important paralog of this gene is TMEM45A.

Additional gene information for TMEM45B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM45B Gene

Genomics for TMEM45B Gene

GeneHancer (GH) Regulatory Elements for TMEM45B Gene

Promoters and enhancers for TMEM45B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I129815 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 571 +1.8 1783 5.1 ELF3 PKNOX1 MLX DMAP1 ZNF48 ZSCAN9 RARA YY1 SLC30A9 CREM TMEM45B GC11M129801 NFRKB PRDM10 PIR42447 GC11M129824
GH11I129814 Enhancer 0.7 ENCODE 550.8 -1.1 -1053 0.1 DRAP1 MEIS2 PKNOX1 NFATC3 TAF9B ASH1L CC2D1A POLR2B ZNF316 MTA3 TMEM45B GC11M129801 GC11M129799
GH11I129817 Enhancer 0.5 ENCODE 550.8 -1.4 -1400 0.2 POLR2B TAF9B GTF2A2 SUPT5H TMEM45B GC11M129801 GC11M129799
GH11I129816 Enhancer 0.4 ENCODE dbSUPER 550.8 -1.8 -1776 0 TMEM45B GC11M129801 GC11M129799
GH11I129823 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.2 +9.0 8991 3.2 SOX13 SAP130 ETV1 ARID4B RARA POLR2A NR2F6 CREM TCF7L2 SOX5 TMEM45B NFRKB APLP2 ARHGAP32 PIR42447 GC11M129824 GC11P129833
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM45B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM45B gene promoter:

Genomic Locations for TMEM45B Gene

Genomic Locations for TMEM45B Gene
chr11:129,815,781-129,860,003
(GRCh38/hg38)
Size:
44,223 bases
Orientation:
Plus strand
chr11:129,685,714-129,729,898
(GRCh37/hg19)

Genomic View for TMEM45B Gene

Genes around TMEM45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM45B Gene

Proteins for TMEM45B Gene

  • Protein details for TMEM45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B21-TM45B_HUMAN
    Recommended name:
    Transmembrane protein 45B
    Protein Accession:
    Q96B21
    Secondary Accessions:
    • A8K2L8

    Protein attributes for TMEM45B Gene

    Size:
    275 amino acids
    Molecular mass:
    31826 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM45B Gene

Post-translational modifications for TMEM45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM45B Gene

Domains & Families for TMEM45B Gene

Gene Families for TMEM45B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM45B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM45B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B21

UniProtKB/Swiss-Prot:

TM45B_HUMAN :
  • Belongs to the TMEM45 family.
Family:
  • Belongs to the TMEM45 family.
genes like me logo Genes that share domains with TMEM45B: view

Function for TMEM45B Gene

Phenotypes From GWAS Catalog for TMEM45B Gene

genes like me logo Genes that share phenotypes with TMEM45B: view

Animal Models for TMEM45B Gene

MGI Knock Outs for TMEM45B:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM45B Gene

Localization for TMEM45B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM45B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM45B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM45B: view

Pathways & Interactions for TMEM45B Gene

SuperPathways for TMEM45B Gene

No Data Available

Interacting Proteins for TMEM45B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281441%0d%0a9606.ENSP00000259782%0d%0a
Selected Interacting proteins: ENSP00000281441 Q96B21-TM45B_HUMAN for TMEM45B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM45B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM45B Gene

Drugs & Compounds for TMEM45B Gene

No Compound Related Data Available

Transcripts for TMEM45B Gene

Unigene Clusters for TMEM45B Gene

Transmembrane protein 45B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TMEM45B Gene

GeneLoc Exon Structure for
TMEM45B
ECgene alternative splicing isoforms for
TMEM45B

Expression for TMEM45B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM45B Gene

This gene is overexpressed in Colon - Transverse (x10.9), Esophagus - Mucosa (x8.4), and Small Intestine - Terminal Ileum (x6.3).

Protein differential expression in normal tissues from HIPED for TMEM45B Gene

This gene is overexpressed in Fetal gut (35.5) and Frontal cortex (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM45B Gene



Protein tissue co-expression partners for TMEM45B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM45B Gene:

TMEM45B

SOURCE GeneReport for Unigene cluster for TMEM45B Gene:

Hs.504301

Evidence on tissue expression from TISSUES for TMEM45B Gene

  • Intestine(4.6)
genes like me logo Genes that share expression patterns with TMEM45B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM45B Gene

Orthologs for TMEM45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM45B 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia TMEM45B 33 34
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Tmem45b 33 16 34
  • 81.82 (n)
cow
(Bos Taurus)
Mammalia TMEM45B 33 34
  • 80.97 (n)
rat
(Rattus norvegicus)
Mammalia Tmem45b 33
  • 79.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM45B 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM45B 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM45B 33
  • 67.4 (n)
-- 34
  • 52 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem45b 33
  • 65.94 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem45b 33 34
  • 61.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8817 34
  • 31 (a)
OneToMany
Species where no ortholog for TMEM45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM45B Gene

ENSEMBL:
Gene Tree for TMEM45B (if available)
TreeFam:
Gene Tree for TMEM45B (if available)

Paralogs for TMEM45B Gene

Paralogs for TMEM45B Gene

(1) SIMAP similar genes for TMEM45B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM45B: view

Variants for TMEM45B Gene

Sequence variations from dbSNP and Humsavar for TMEM45B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000057972 -- 129,830,713(+) T/C intron_variant
rs1000071978 -- 129,837,582(+) G/A intron_variant
rs1000202642 -- 129,859,387(+) A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000225718 -- 129,843,886(+) A/C intron_variant
rs1000257925 -- 129,856,360(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM45B Gene

Variant ID Type Subtype PubMed ID
esv2760198 CNV loss 21179565
esv3579968 CNV loss 25503493
esv3628071 CNV loss 21293372
esv3892108 CNV loss 25118596
nsv1042946 CNV loss 25217958
nsv1122679 CNV deletion 24896259
nsv39607 CNV deletion 16902084
nsv983077 CNV duplication 23825009

Variation tolerance for TMEM45B Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM45B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM45B Gene

Disorders for TMEM45B Gene

Additional Disease Information for TMEM45B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM45B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM45B Gene

Publications for TMEM45B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for TMEM45B Gene

Sources for TMEM45B Gene

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