Aliases for TMEM39B Gene

Aliases for TMEM39B Gene

  • Transmembrane Protein 39B 2 3 4 5

External Ids for TMEM39B Gene

Previous GeneCards Identifiers for TMEM39B Gene

  • GC01P032207
  • GC01P032310
  • GC01P032537
  • GC01P030655

Summaries for TMEM39B Gene

GeneCards Summary for TMEM39B Gene

TMEM39B (Transmembrane Protein 39B) is a Protein Coding gene. An important paralog of this gene is TMEM39A.

Additional gene information for TMEM39B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM39B Gene

Genomics for TMEM39B Gene

GeneHancer (GH) Regulatory Elements for TMEM39B Gene

Promoters and enhancers for TMEM39B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM39B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM39B

Top Transcription factor binding sites by QIAGEN in the TMEM39B gene promoter:
  • C/EBPalpha
  • Cart-1
  • CHOP-10
  • E47
  • Evi-1
  • GATA-1
  • Pax-4a
  • RP58

Genomic Locations for TMEM39B Gene

Genomic Locations for TMEM39B Gene
chr1:32,072,031-32,102,866
(GRCh38/hg38)
Size:
30,836 bases
Orientation:
Plus strand
chr1:32,537,632-32,568,467
(GRCh37/hg19)
Size:
30,836 bases
Orientation:
Plus strand

Genomic View for TMEM39B Gene

Genes around TMEM39B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM39B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM39B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM39B Gene

Proteins for TMEM39B Gene

  • Protein details for TMEM39B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU3-TM39B_HUMAN
    Recommended name:
    Transmembrane protein 39B
    Protein Accession:
    Q9GZU3
    Secondary Accessions:
    • B4DKN8
    • B4DQE6
    • B4DTN8
    • D3DPP4
    • Q6IA44

    Protein attributes for TMEM39B Gene

    Size:
    492 amino acids
    Molecular mass:
    56274 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM39B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM39B Gene

Post-translational modifications for TMEM39B Gene

  • Glycosylation at Asn8
  • Ubiquitination at Lys234 and Lys475
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM39B Gene

Domains & Families for TMEM39B Gene

Gene Families for TMEM39B Gene

Protein Domains for TMEM39B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM39B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52514, highly similar to Rattus norvegicus transmembrane protein 39b (Tmem39b), mRNA (B4DKN8_HUMAN)
  • cDNA FLJ59380, highly similar to Homo sapiens transmembrane protein 39B (TMEM39B), mRNA (B4DQE6_HUMAN)
  • cDNA FLJ61393, highly similar to Mus musculus transmembrane protein 39b (Tmem39b), mRNA (B4DTN8_HUMAN)
  • TMEM39B protein (Q9BT39_HUMAN)
  • cDNA FLJ10315 fis, clone NT2RM2000395 (Q9NW51_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZU3

UniProtKB/Swiss-Prot:

TM39B_HUMAN :
  • Belongs to the TMEM39 family.
Family:
  • Belongs to the TMEM39 family.
genes like me logo Genes that share domains with TMEM39B: view

Function for TMEM39B Gene

Phenotypes From GWAS Catalog for TMEM39B Gene

genes like me logo Genes that share phenotypes with TMEM39B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM39B Gene

Localization for TMEM39B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM39B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM39B gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM39B: view

Pathways & Interactions for TMEM39B Gene

PathCards logo

SuperPathways for TMEM39B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM39B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM39B Gene

Drugs & Compounds for TMEM39B Gene

No Compound Related Data Available

Transcripts for TMEM39B Gene

mRNA/cDNA for TMEM39B Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM39B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - - - -
SP15: -
SP16: -

ExUns: 11c ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TMEM39B Gene

GeneLoc Exon Structure for
TMEM39B

Expression for TMEM39B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM39B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM39B Gene

This gene is overexpressed in Synovial fluid (36.6) and Peripheral blood mononuclear cells (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM39B Gene



Protein tissue co-expression partners for TMEM39B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM39B

SOURCE GeneReport for Unigene cluster for TMEM39B Gene:

Hs.25544

Evidence on tissue expression from TISSUES for TMEM39B Gene

  • Nervous system(4.5)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TMEM39B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM39B Gene

Orthologs for TMEM39B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM39B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM39B 31 30
  • 99.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM39B 31 30
  • 93.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM39B 31 30
  • 93.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem39b 17 31 30
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Tmem39b 30
  • 91.12 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM39B 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM39B 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM39B 31 30
  • 77.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM39B 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem39b 30
  • 70.08 (n)
Str.15850 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4712 30
zebrafish
(Danio rerio)
Actinopterygii tmem39b 31 30
  • 67.85 (n)
OneToOne
wufi31h12 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6164 30
fruit fly
(Drosophila melanogaster)
Insecta CG13016 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D1007.5 31
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for TMEM39B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM39B Gene

ENSEMBL:
Gene Tree for TMEM39B (if available)
TreeFam:
Gene Tree for TMEM39B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM39B: view image

Paralogs for TMEM39B Gene

Paralogs for TMEM39B Gene

(1) SIMAP similar genes for TMEM39B Gene using alignment to 8 proteins:

  • TM39B_HUMAN
  • B4DKN8_HUMAN
  • B4DQE6_HUMAN
  • B4DTN8_HUMAN
  • F8WB89_HUMAN
  • Q5VVU5_HUMAN
  • Q9BT39_HUMAN
  • Q9NW51_HUMAN
genes like me logo Genes that share paralogs with TMEM39B: view

Variants for TMEM39B Gene

Additional dbSNP identifiers (rs#s) for TMEM39B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM39B Gene

Variant ID Type Subtype PubMed ID
dgv224n54 CNV loss 21841781
dgv225n54 CNV loss 21841781
esv25480 CNV loss 19812545
esv2674125 CNV deletion 23128226
esv3560393 CNV deletion 23714750
esv3585663 CNV loss 21293372
esv3585664 CNV loss 21293372
esv3585665 CNV loss 21293372
esv3585666 CNV loss 21293372
nsv1154076 CNV insertion 26484159
nsv545957 CNV loss 21841781

Variation tolerance for TMEM39B Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM39B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM39B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM39B Gene

Disorders for TMEM39B Gene

Additional Disease Information for TMEM39B

No disorders were found for TMEM39B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM39B Gene

Publications for TMEM39B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TMEM39B Gene

Sources for TMEM39B Gene