Aliases for TMEM38A Gene

Aliases for TMEM38A Gene

  • Transmembrane Protein 38A 2 3 4 5
  • TRIC-A 2 3 4
  • Trimeric Intracellular Cation Channel Type A 3 4
  • TRICA 3 4
  • TMEM38A 5
  • MGC3169 2

External Ids for TMEM38A Gene

Previous GeneCards Identifiers for TMEM38A Gene

  • GC19P016633
  • GC19P016771
  • GC19P016340

Summaries for TMEM38A Gene

GeneCards Summary for TMEM38A Gene

TMEM38A (Transmembrane Protein 38A) is a Protein Coding gene. Diseases associated with TMEM38A include Hyperalphalipoproteinemia 1 and Myopathy, X-Linked, With Postural Muscle Atrophy. Gene Ontology (GO) annotations related to this gene include potassium channel activity and cation channel activity. An important paralog of this gene is TMEM38B.

UniProtKB/Swiss-Prot Summary for TMEM38A Gene

  • Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

Additional gene information for TMEM38A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM38A Gene

Genomics for TMEM38A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM38A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM38A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM38A

Top Transcription factor binding sites by QIAGEN in the TMEM38A gene promoter:
  • AhR
  • AREB6
  • Arnt
  • c-Ets-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NRF-2

Genomic Locations for TMEM38A Gene

Genomic Locations for TMEM38A Gene
chr19:16,661,139-16,690,023
(GRCh38/hg38)
Size:
28,885 bases
Orientation:
Plus strand
chr19:16,771,938-16,800,840
(GRCh37/hg19)
Size:
28,903 bases
Orientation:
Plus strand

Genomic View for TMEM38A Gene

Genes around TMEM38A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM38A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM38A Gene

Proteins for TMEM38A Gene

  • Protein details for TMEM38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F2-TM38A_HUMAN
    Recommended name:
    Trimeric intracellular cation channel type A
    Protein Accession:
    Q9H6F2
    Secondary Accessions:
    • A8K9P9

    Protein attributes for TMEM38A Gene

    Size:
    299 amino acids
    Molecular mass:
    33260 Da
    Quaternary structure:
    • Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).

neXtProt entry for TMEM38A Gene

Post-translational modifications for TMEM38A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM38A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for TMEM38A
  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM38A

No data available for DME Specific Peptides for TMEM38A Gene

Domains & Families for TMEM38A Gene

Gene Families for TMEM38A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM38A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 38A (TM38A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H6F2

UniProtKB/Swiss-Prot:

TM38A_HUMAN :
  • Belongs to the TMEM38 family.
Family:
  • Belongs to the TMEM38 family.
genes like me logo Genes that share domains with TMEM38A: view

Function for TMEM38A Gene

Molecular function for TMEM38A Gene

UniProtKB/Swiss-Prot Function:
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

Phenotypes From GWAS Catalog for TMEM38A Gene

Gene Ontology (GO) - Molecular Function for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IEA --
GO:0005267 potassium channel activity TAS 19095005
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TMEM38A: view
genes like me logo Genes that share phenotypes with TMEM38A: view

Animal Models for TMEM38A Gene

MGI Knock Outs for TMEM38A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM38A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM38A Gene

Localization for TMEM38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM38A Gene

Sarcoplasmic reticulum membrane. Multi-pass membrane protein. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM38A gene
Compartment Confidence
extracellular 4
nucleus 4
endoplasmic reticulum 4
plasma membrane 3
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with TMEM38A: view

Pathways & Interactions for TMEM38A Gene

PathCards logo

SuperPathways for TMEM38A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0007029 endoplasmic reticulum organization IEA --
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IEA --
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with TMEM38A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM38A Gene

Drugs & Compounds for TMEM38A Gene

(1) Drugs for TMEM38A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with TMEM38A: view

Transcripts for TMEM38A Gene

mRNA/cDNA for TMEM38A Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM38A

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM38A Gene

No ASD Table

Relevant External Links for TMEM38A Gene

GeneLoc Exon Structure for
TMEM38A

Expression for TMEM38A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM38A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM38A Gene

This gene is overexpressed in Muscle - Skeletal (x21.6).

Protein differential expression in normal tissues from HIPED for TMEM38A Gene

This gene is overexpressed in Heart (25.1), Breast (18.9), Esophagus (10.3), and Frontal cortex (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM38A Gene



Protein tissue co-expression partners for TMEM38A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM38A

SOURCE GeneReport for Unigene cluster for TMEM38A Gene:

Hs.436068

Evidence on tissue expression from TISSUES for TMEM38A Gene

  • Eye(4.1)
  • Muscle(3.7)
  • Heart(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TMEM38A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM38A Gene

Orthologs for TMEM38A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM38A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM38A 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM38A 30 31
  • 91.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM38A 30 31
  • 91.19 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM38A 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem38a 30 17 31
  • 85.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem38a 30
  • 84.51 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM38A 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM38A 30 31
  • 73.31 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem38a 30
  • 70.8 (n)
MGC75707 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53433 30
Zebrafish
(Danio rerio)
Actinopterygii tmem38a 30 31
  • 69.04 (n)
OneToOne
zgc77831 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.371 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG4239 31
  • 35 (a)
ManyToMany
CG33061 31
  • 23 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y57A10A.10 31
  • 29 (a)
ManyToMany
Y57A10A.28 31
  • 28 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8498 31
  • 28 (a)
OneToMany
Species where no ortholog for TMEM38A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM38A Gene

ENSEMBL:
Gene Tree for TMEM38A (if available)
TreeFam:
Gene Tree for TMEM38A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM38A: view image

Paralogs for TMEM38A Gene

Paralogs for TMEM38A Gene

(1) SIMAP similar genes for TMEM38A Gene using alignment to 2 proteins:

  • TM38A_HUMAN
  • M0QYB6_HUMAN

Pseudogenes.org Pseudogenes for TMEM38A Gene

genes like me logo Genes that share paralogs with TMEM38A: view

Variants for TMEM38A Gene

Additional dbSNP identifiers (rs#s) for TMEM38A Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM38A Gene

Variant ID Type Subtype PubMed ID
esv2669434 CNV deletion 23128226
esv3556105 CNV deletion 23714750
nsv1118360 CNV deletion 24896259
nsv1135850 CNV deletion 24896259

Variation tolerance for TMEM38A Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM38A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM38A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM38A Gene

Disorders for TMEM38A Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM38A Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperalphalipoproteinemia 1
  • halp1
myopathy, x-linked, with postural muscle atrophy
  • xmpma
heel spur
  • calcaneal spur
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM38A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TMEM38A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM38A Gene

Publications for TMEM38A Gene

  1. TRIC channels are essential for Ca2+ handling in intracellular stores. (PMID: 17611541) Yazawa M … Takeshima H (Nature 2007) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for TMEM38A Gene

Sources for TMEM38A Gene