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Aliases for TMEM273 Gene

Aliases for TMEM273 Gene

  • Transmembrane Protein 273 2 3 4 5
  • C10orf128 3 4
  • Putative Uncharacterized Protein C10orf128 3
  • Chromosome 10 Open Reading Frame 128 2

External Ids for TMEM273 Gene

Previous HGNC Symbols for TMEM273 Gene

  • C10orf128

Summaries for TMEM273 Gene

GeneCards Summary for TMEM273 Gene

TMEM273 (Transmembrane Protein 273) is a Protein Coding gene. Diseases associated with TMEM273 include Basal Cell Nevus Syndrome.

Additional gene information for TMEM273 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM273 Gene

Genomics for TMEM273 Gene

GeneHancer (GH) Regulatory Elements for TMEM273 Gene

Promoters and enhancers for TMEM273 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049183 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 627.9 +1.3 1303 8.3 CC2D1A CBFA2T2 MLLT1 POLR2A GTF2F1 CSDE1 ZNF687 BACH1 TRIM24 ZNF639 TMEM273 VSTM4 LINC00843 AGAP6 ERCC6 WASHC2A RNA5SP317 FAM170B
GH10J049359 Enhancer 1.3 FANTOM5 Ensembl ENCODE 18.1 -172.0 -172049 6.1 ELF3 RELA SP1 HNF1A CREM ZNF644 IKZF1 IKZF2 CEBPA GATAD2A TMEM273 DRGX GC10M049333 C10orf71-AS1
GH10J049163 Enhancer 1 FANTOM5 ENCODE dbSUPER 22.8 +24.7 24698 0.2 MLLT1 MGA EHMT2 FOS FOSL1 ZNF592 JUN IKZF1 ZBTB33 SMARCA4 TMEM273 ENSG00000226576 FAM170B
GH10J049176 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 14.6 +11.0 10952 1.9 SP1 CC2D1A ZNF687 BACH1 RELA CREM MLLT1 ZNF639 SMARCA4 ZBED1 LINC00843 TMEM273 ERCC6 RNA5SP317 PARG RPL21P89 FAM170B
GH10J049212 Enhancer 0.8 Ensembl 23.9 -24.1 -24116 1 CBFA2T2 MLLT1 GTF2F1 MCM2 SMARCA4 MTA1 GMEB1 ARID2 DPF2 RNF2 TMEM273 WASHC2A DRGX FAM170B-AS1 C10orf71 C10orf71-AS1 LINC00843 VSTM4 GC10P049274
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM273 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM273 Gene

Genomic Locations for TMEM273 Gene
chr10:49,154,724-49,188,585
(GRCh38/hg38)
Size:
33,862 bases
Orientation:
Minus strand
chr10:50,362,773-50,396,630
(GRCh37/hg19)
Size:
33,858 bases
Orientation:
Minus strand

Genomic View for TMEM273 Gene

Genes around TMEM273 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM273 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM273 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM273 Gene

Proteins for TMEM273 Gene

  • Protein details for TMEM273 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T292-TM273_HUMAN
    Recommended name:
    Transmembrane protein 273
    Protein Accession:
    Q5T292
    Secondary Accessions:
    • A6XND2
    • Q5T289
    • Q5T291

    Protein attributes for TMEM273 Gene

    Size:
    105 amino acids
    Molecular mass:
    11325 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM273 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM273 Gene

Post-translational modifications for TMEM273 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM273 Gene

Domains & Families for TMEM273 Gene

Gene Families for TMEM273 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM273 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM273: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM273 Gene

Function for TMEM273 Gene

Phenotypes From GWAS Catalog for TMEM273 Gene

Phenotypes for TMEM273 Gene

genes like me logo Genes that share phenotypes with TMEM273: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM273 Gene

Localization for TMEM273 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM273 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM273 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM273: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM273 Gene

Pathways & Interactions for TMEM273 Gene

PathCards logo

SuperPathways for TMEM273 Gene

No Data Available

Interacting Proteins for TMEM273 Gene

Gene Ontology (GO) - Biological Process for TMEM273 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM273 Gene

Drugs & Compounds for TMEM273 Gene

No Compound Related Data Available

Transcripts for TMEM273 Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM273 Gene

No ASD Table

Relevant External Links for TMEM273 Gene

GeneLoc Exon Structure for
TMEM273
ECgene alternative splicing isoforms for
TMEM273

Expression for TMEM273 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM273 Gene:

TMEM273

Evidence on tissue expression from TISSUES for TMEM273 Gene

  • Nervous system(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM273 Gene

Orthologs for TMEM273 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM273 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C28H10orf128 34
  • 79.37 (n)
C10orf128 35
  • 38 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf128 34
  • 79.05 (n)
C10orf128 35
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810011H11Rik 35 34
  • 77.3 (n)
OneToOne
Tmem273 17
rat
(Rattus norvegicus)
Mammalia RGD1561145 34
  • 74.11 (n)
chimpanzee
(Pan troglodytes)
Mammalia C10orf128 35
  • 74 (a)
OneToOne
Species where no ortholog for TMEM273 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM273 Gene

ENSEMBL:
Gene Tree for TMEM273 (if available)
TreeFam:
Gene Tree for TMEM273 (if available)

Paralogs for TMEM273 Gene

No data available for Paralogs for TMEM273 Gene

Variants for TMEM273 Gene

Sequence variations from dbSNP and Humsavar for TMEM273 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000016746 -- 49,170,116(-) C/G intron_variant
rs1000043776 -- 49,184,909(-) G/T intron_variant
rs1000095704 -- 49,165,708(-) C/G/T intron_variant
rs1000171562 -- 49,186,360(-) T/C intron_variant
rs1000230175 -- 49,176,968(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM273 Gene

Variant ID Type Subtype PubMed ID
esv3623165 CNV loss 21293372
esv3623166 CNV gain 21293372
esv3623167 CNV gain 21293372
nsv1042677 CNV loss 25217958
nsv1113295 CNV deletion 24896259

Variation tolerance for TMEM273 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM273 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM273

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM273 Gene

Disorders for TMEM273 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM273 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basal cell nevus syndrome
  • bcns
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMEM273: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM273 Gene

Publications for TMEM273 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G … Peterson K (Molecular vision 2002) 3 58

Products for TMEM273 Gene

Sources for TMEM273 Gene

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