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Aliases for TMEM268 Gene

Aliases for TMEM268 Gene

  • Transmembrane Protein 268 2 3 4 5
  • C9orf91 3 4
  • Chromosome 9 Open Reading Frame 91 2
  • Transmembrane Protein C9orf91 3

External Ids for TMEM268 Gene

Previous HGNC Symbols for TMEM268 Gene

  • C9orf91

Summaries for TMEM268 Gene

GeneCards Summary for TMEM268 Gene

TMEM268 (Transmembrane Protein 268) is a Protein Coding gene.

Additional gene information for TMEM268 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM268 Gene

Genomics for TMEM268 Gene

GeneHancer (GH) Regulatory Elements for TMEM268 Gene

Promoters and enhancers for TMEM268 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J114610 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 605.2 +8.7 8668 4.5 ELF3 ZFX ZNF148 NKRF MLLT1 ZNF121 CEBPG GTF2F1 CSDE1 ZNF687 TMEM268 GC09P115118 WHRN ENSG00000201749 GC09M114616
GH09J114360 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -227.8 -227806 30.6 MTA3 ZNF652 SP1 NKRF ZNF121 CEBPG POLR2A ZNF687 ZNF24 RELA AKNA WHRN TMEM268 ENSG00000201749 ORM1 ORM2 ATP6V1G1 ENSG00000235119
GH09J114480 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -119.8 -119841 9.4 SP1 CC2D1A CTCF NKRF MLLT1 CSDE1 ZNF687 TRIM24 RELA CREM WHRN TNFSF15 TMEM268 ENSG00000201749 TNC TNFSF8 ATP6V1G1 LOC100131877 AKNA
GH09J114348 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10 -254.6 -254627 2.5 SP1 ZNF148 ZNF687 RELA MZF1 EGR1 IKZF1 GLIS2 POLR2A PKNOX1 AKNA WHRN COL27A1 TMEM268 ENSG00000201749 ORM2 ENSG00000235119
GH09J115014 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +411.4 411359 5 CTCF RAD21 IKZF1 REST TRIM22 DEK SMC3 KLF13 STAT1 ZNF654 TNFSF8 TNFSF15 ENSG00000201749 TMEM268 TNC ATP6V1G1 GC09M115052 DEC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM268 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM268 Gene

Genomic Locations for TMEM268 Gene
42,482 bases
Plus strand
35,218 bases
Plus strand

Genomic View for TMEM268 Gene

Genes around TMEM268 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM268 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM268 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM268 Gene

Proteins for TMEM268 Gene

  • Protein details for TMEM268 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 268
    Protein Accession:
    Secondary Accessions:
    • A0PJA3
    • Q3KNS4
    • Q5VZI2
    • Q6P5Z7
    • Q8N1P3
    • Q8ND43

    Protein attributes for TMEM268 Gene

    342 amino acids
    Molecular mass:
    37569 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM268 Gene


neXtProt entry for TMEM268 Gene

Post-translational modifications for TMEM268 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM268 Gene

Domains & Families for TMEM268 Gene

Gene Families for TMEM268 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM268 Gene


Suggested Antigen Peptide Sequences for TMEM268 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C9orf91 (CI091_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM268: view

No data available for UniProtKB/Swiss-Prot for TMEM268 Gene

Function for TMEM268 Gene

Phenotypes From GWAS Catalog for TMEM268 Gene

Gene Ontology (GO) - Molecular Function for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM268: view
genes like me logo Genes that share phenotypes with TMEM268: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM268 - Now 50% OFF >
  • * TMEM268 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM268 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM268 Gene

Localization for TMEM268 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM268 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM268 gene
Compartment Confidence
plasma membrane 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM268: view

Pathways & Interactions for TMEM268 Gene

PathCards logo

SuperPathways for TMEM268 Gene

No Data Available

Interacting Proteins for TMEM268 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
Selected Interacting proteins: Q5VZI3-TM268_HUMAN ENSP00000288502 for TMEM268 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM268: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM268 Gene

Drugs & Compounds for TMEM268 Gene

No Compound Related Data Available

Transcripts for TMEM268 Gene

mRNA/cDNA for TMEM268 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM268 - Now 50% OFF >
  • * TMEM268 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM268 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM268 Gene

No ASD Table

Relevant External Links for TMEM268 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM268 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM268 Gene:


Evidence on tissue expression from TISSUES for TMEM268 Gene

  • Nervous system(4.4)
  • Lung(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM268 Gene

Orthologs for TMEM268 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM268 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C9H9orf91 34
  • 99.22 (n)
C9ORF91 35
  • 99 (a)
(Canis familiaris)
Mammalia C9orf91 35
  • 90 (a)
C11H9orf91 34
  • 87.82 (n)
(Bos Taurus)
Mammalia C9orf91 35
  • 88 (a)
C8H9orf91 34
  • 87.33 (n)
(Mus musculus)
Mammalia 6330416G13Rik 35 34
  • 85.92 (n)
Tmem268 17
(Rattus norvegicus)
Mammalia RGD1304595 34
  • 85.04 (n)
(Monodelphis domestica)
Mammalia C9orf91 35
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf91 35
  • 50 (a)
(Gallus gallus)
Aves C17H9ORF91 34
  • 61.37 (n)
C9orf91 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485830 34
  • 52.26 (n)
(Danio rerio)
Actinopterygii LOC559789 34
  • 46.21 (n)
C19H9orf91 35
  • 28 (a)
Species where no ortholog for TMEM268 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM268 Gene

Gene Tree for TMEM268 (if available)
Gene Tree for TMEM268 (if available)

Paralogs for TMEM268 Gene

No data available for Paralogs for TMEM268 Gene

Variants for TMEM268 Gene

Sequence variations from dbSNP and Humsavar for TMEM268 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000047619 -- 114,627,561(+) A/G intron_variant
rs1000082685 -- 114,632,140(+) C/T intron_variant
rs1000260239 -- 114,643,567(+) A/G 3_prime_UTR_variant, intron_variant
rs1000291332 -- 114,643,191(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000358830 -- 114,614,250(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM268 Gene

Variant ID Type Subtype PubMed ID
dgv12859n54 CNV gain 21841781
dgv7706n100 CNV gain 25217958
dgv948n27 CNV gain 19166990
esv1008480 CNV deletion 20482838
nsv520757 CNV gain 19592680
nsv615249 CNV loss 21841781
nsv6679 CNV insertion 18451855
nsv7433 OTHER inversion 18451855
nsv831694 CNV gain 17160897

Variation tolerance for TMEM268 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM268 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM268 Gene

Disorders for TMEM268 Gene

Additional Disease Information for TMEM268

No disorders were found for TMEM268 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM268 Gene

Publications for TMEM268 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for TMEM268 Gene

  • Biorbyt antibodies for TMEM268

Sources for TMEM268 Gene

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