Aliases for TMEM267 Gene

Aliases for TMEM267 Gene

  • Transmembrane Protein 267 2 3 4 5
  • C5orf28 3 4
  • Chromosome 5 Open Reading Frame 28 2
  • Transmembrane Protein C5orf28 3

External Ids for TMEM267 Gene

Previous HGNC Symbols for TMEM267 Gene

  • C5orf28

Summaries for TMEM267 Gene

GeneCards Summary for TMEM267 Gene

TMEM267 (Transmembrane Protein 267) is a Protein Coding gene.

Additional gene information for TMEM267 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM267 Gene

Genomics for TMEM267 Gene

GeneHancer (GH) Regulatory Elements for TMEM267 Gene

Promoters and enhancers for TMEM267 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM267 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM267

Genomic Locations for TMEM267 Gene

Genomic Locations for TMEM267 Gene
40,927 bases
Minus strand
39,642 bases
Minus strand

Genomic View for TMEM267 Gene

Genes around TMEM267 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM267 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM267 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM267 Gene

Proteins for TMEM267 Gene

  • Protein details for TMEM267 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 267
    Protein Accession:
    Secondary Accessions:
    • B2RDA6
    • Q9H6Z2

    Protein attributes for TMEM267 Gene

    215 amino acids
    Molecular mass:
    24217 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM267 Gene

Post-translational modifications for TMEM267 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM267 Gene

Domains & Families for TMEM267 Gene

Gene Families for TMEM267 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM267 Gene


Suggested Antigen Peptide Sequences for TMEM267 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C5orf28 (CE028_HUMAN)
genes like me logo Genes that share domains with TMEM267: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM267 Gene

Function for TMEM267 Gene

Phenotypes From GWAS Catalog for TMEM267 Gene

genes like me logo Genes that share phenotypes with TMEM267: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM267

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM267 Gene

Localization for TMEM267 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM267 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM267 gene
Compartment Confidence
peroxisome 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM267: view

Pathways & Interactions for TMEM267 Gene

PathCards logo

SuperPathways for TMEM267 Gene

No Data Available

Interacting Proteins for TMEM267 Gene


Gene Ontology (GO) - Biological Process for TMEM267 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM267 Gene

Drugs & Compounds for TMEM267 Gene

No Compound Related Data Available

Transcripts for TMEM267 Gene

mRNA/cDNA for TMEM267 Gene

11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM267

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM267 Gene

No ASD Table

Relevant External Links for TMEM267 Gene

GeneLoc Exon Structure for

Expression for TMEM267 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM267

Evidence on tissue expression from TISSUES for TMEM267 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM267 Gene

Orthologs for TMEM267 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM267 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5orf28 31
  • 100 (a)
C5H5orf28 30
  • 99.53 (n)
(Canis familiaris)
Mammalia C4H5orf28 30
  • 91.63 (n)
C5orf28 31
  • 79 (a)
(Bos Taurus)
Mammalia C20H5orf28 30
  • 90.08 (n)
C5orf28 31
  • 90 (a)
(Monodelphis domestica)
Mammalia C5orf28 31
  • 83 (a)
(Mus musculus)
Mammalia Gm7120 31 30
  • 80.93 (n)
Gm21967 31
  • 71 (a)
Tmem267 17
(Rattus norvegicus)
Mammalia RGD1562550 30
  • 80.78 (n)
(Ornithorhynchus anatinus)
Mammalia C5orf28 31
  • 75 (a)
(Gallus gallus)
Aves CZH5ORF28 30
  • 78.91 (n)
C5orf28 31
  • 78 (a)
(Anolis carolinensis)
Reptilia C5orf28 31
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490930 30
  • 68.06 (n)
(Danio rerio)
Actinopterygii si:busm1-79m10.4 30
  • 64.81 (n)
C10H5orf28 31
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10866 31 30
  • 48.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005379 30
  • 43.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
Species where no ortholog for TMEM267 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM267 Gene

Gene Tree for TMEM267 (if available)
Gene Tree for TMEM267 (if available)

Paralogs for TMEM267 Gene

No data available for Paralogs for TMEM267 Gene

Variants for TMEM267 Gene

Additional dbSNP identifiers (rs#s) for TMEM267 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM267 Gene

Variant ID Type Subtype PubMed ID
esv2597772 CNV deletion 19546169
esv2665243 CNV deletion 23128226
esv3565866 CNV deletion 23714750
esv3604903 CNV loss 21293372
nsv478024 CNV novel sequence insertion 20440878
nsv830275 CNV gain 17160897

Variation tolerance for TMEM267 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM267 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM267 Gene

Disorders for TMEM267 Gene

Additional Disease Information for TMEM267

No disorders were found for TMEM267 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM267 Gene

Publications for TMEM267 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 54

Products for TMEM267 Gene

Sources for TMEM267 Gene