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TMEM266 (Transmembrane Protein 266) is a Protein Coding gene. Diseases associated with TMEM266 include Familial Periodic Paralysis and Hypokalemic Periodic Paralysis, Type 1. An important paralog of this gene is TNS3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH15J076058 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | -0.1 | -113 | 2.4 | HNRNPL CTCF TARDBP LARP7 RELA ZIC2 PATZ1 RAD21 IKZF2 ZNF501 | TMEM266 lnc-FBXO22-5 NRG4 FBXO22 ENSG00000187812 DNM1P35 lnc-ETFA-2 | |
GH15J076113 | Promoter | 0.4 | EPDnew | 600.2 | +53.8 | 53832 | 0.1 | CTCF | TMEM266 piR-57133-193 NRG4 lnc-FBXO22-5 LOC101929439 ETFA | |
GH15J076061 | Enhancer | 0.2 | Ensembl | 600.7 | +1.6 | 1588 | 0.6 | TMEM266 lnc-FBXO22-5 NRG4 | ||
GH15J076190 | Promoter/Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 10.2 | +131.1 | 131099 | 1.2 | CTCF TARDBP ZNF143 RXRB REST RAD21 IRF2 TRIM22 EZH2 GTF2F1 | lnc-ETFA-6 SCAPER NRG4 TMEM266 MIR631 LOC101929439 ETFA | |
GH15J076195 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 10.2 | +138.4 | 138388 | 5.8 | HNRNPL GATAD2A TFE3 NFKBIZ KDM1A JUND ZIC2 PKNOX1 RXRB IRF2 | SCAPER NRG4 TMEM266 ISL2 ETFA TSPAN3 lnc-ETFA-6 ENSG00000196274 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015267 | NOT channel activity | IDA | 25165868 |
GO:0022832 | NOT voltage-gated channel activity | IEA,IDA | 30810529 |
GO:0042803 | protein homodimerization activity | IDA | 30810529 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IEA,IDA | -- |
GO:0005887 | integral component of plasma membrane | IEA,IDA | 25165868 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0055085 | transmembrane transport | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | C15H15orf27 30 |
|
||
C15orf27 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | C21H15orf27 30 |
|
||
C15orf27 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | RGD1562084 30 |
|
||
Mouse (Mus musculus) |
Mammalia | AI118078 30 31 |
|
OneToOne | |
Tmem266 17 |
|
||||
Dog (Canis familiaris) |
Mammalia | LOC487670 30 |
|
||
C15orf27 31 |
|
OneToOne | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | C15orf27 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | C15orf27 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | C15ORF27 30 |
|
||
C15orf27 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | C15orf27 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | zgc:158624 30 |
|
||
C25H15orf27 31 |
|
OneToOne | |||
Dr.14493 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2623n100 | CNV | gain | 25217958 |
dgv2624n100 | CNV | gain | 25217958 |
dgv2625n100 | CNV | gain | 25217958 |
dgv2626n100 | CNV | gain | 25217958 |
esv2660944 | CNV | deletion | 23128226 |
esv2665159 | CNV | deletion | 23128226 |
esv2669418 | CNV | deletion | 23128226 |
esv274972 | CNV | loss | 21479260 |
esv2749895 | CNV | deletion | 23290073 |
esv2749898 | CNV | deletion | 23290073 |
esv3350114 | CNV | insertion | 20981092 |
esv3552697 | CNV | deletion | 23714750 |
esv3636935 | CNV | loss | 21293372 |
esv3636937 | CNV | loss | 21293372 |
esv3636938 | CNV | loss | 21293372 |
nsv1048760 | CNV | gain | 25217958 |
nsv1054713 | CNV | gain | 25217958 |
nsv1108967 | CNV | deletion | 24896259 |
nsv1116463 | OTHER | inversion | 24896259 |
nsv1142180 | CNV | tandem duplication | 24896259 |
nsv1617 | CNV | deletion | 18451855 |
nsv569998 | CNV | gain | 21841781 |
nsv833057 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial periodic paralysis |
|
|
hypokalemic periodic paralysis, type 1 |
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|