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Aliases for TMEM263 Gene

Aliases for TMEM263 Gene

  • Transmembrane Protein 263 2 3 4 5
  • C12orf23 3 4
  • UPF0444 Transmembrane Protein C12orf23 3
  • Chromosome 12 Open Reading Frame 23 2

External Ids for TMEM263 Gene

Previous HGNC Symbols for TMEM263 Gene

  • C12orf23

Previous GeneCards Identifiers for TMEM263 Gene

  • GC12P107350

Summaries for TMEM263 Gene

GeneCards Summary for TMEM263 Gene

TMEM263 (Transmembrane Protein 263) is a Protein Coding gene.

Additional gene information for TMEM263 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM263 Gene

Genomics for TMEM263 Gene

GeneHancer (GH) Regulatory Elements for TMEM263 Gene

Promoters and enhancers for TMEM263 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106954 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 613.7 +3.1 3088 5 ZFX MNT ZNF148 NKRF POLR2A MLLT1 GTF2F1 CSDE1 ZNF384 ZNF687 ENSG00000260329 TMEM263 GC12M106953 MTERF2 PRDM4 PWP1 GC12P106984
GH12J106953 Enhancer 0.6 ENCODE 600.7 +0.4 363 0.2 ZNF121 ZIC2 JUND WT1 HIC1 ADNP FOS PRDM6 ENSG00000260329 GC12M106953 TMEM263
GH12J106903 Promoter/Enhancer 1.1 Ensembl ENCODE 23.1 -49.7 -49714 1 SP7 PKNOX1 IKZF1 PATZ1 KLF9 SP2 ZBTB17 TFAP4 SIN3A SP3 EEF1B2P4 TMEM263 ENSG00000260329 POLR3B RIC8B RPL30P12
GH12J106918 Enhancer 0.9 Ensembl ENCODE 23.5 -35.3 -35314 11 CTCF MAFK RAD21 IKZF1 CEBPA REST TRIM22 IKZF2 RUNX3 RFX5 TMEM263 MTERF2 ENSG00000260329 POLR3B RPL30P12 GC12P106941
GH12J106908 Enhancer 0.8 Ensembl 24.1 -43.6 -43614 3.6 SP1 NKRF MLLT1 JUND RELA IKZF1 BACH1 IKZF2 ZNF512 TRIM22 RPL30P12 TMEM263 MTERF2 POLR3B ENSG00000260329 EEF1B2P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM263 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM263 Gene

Genomic Locations for TMEM263 Gene
chr12:106,953,415-106,978,778
(GRCh38/hg38)
Size:
25,364 bases
Orientation:
Plus strand
chr12:107,349,544-107,367,813
(GRCh37/hg19)
Size:
18,270 bases
Orientation:
Plus strand

Genomic View for TMEM263 Gene

Genes around TMEM263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM263 Gene

Proteins for TMEM263 Gene

  • Protein details for TMEM263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH6-TM263_HUMAN
    Recommended name:
    Transmembrane protein 263
    Protein Accession:
    Q8WUH6
    Secondary Accessions:
    • B3KMN9

    Protein attributes for TMEM263 Gene

    Size:
    116 amino acids
    Molecular mass:
    11748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM263 Gene

Post-translational modifications for TMEM263 Gene

  • Glycosylation at posLast=22
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM263 Gene

Domains & Families for TMEM263 Gene

Gene Families for TMEM263 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMEM263 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM263 Gene

GenScript: Design optimal peptide antigens:
  • UPF0444 transmembrane protein C12orf23 (CL023_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WUH6

UniProtKB/Swiss-Prot:

TM263_HUMAN :
  • Belongs to the TMEM263 family.
Family:
  • Belongs to the TMEM263 family.
genes like me logo Genes that share domains with TMEM263: view

Function for TMEM263 Gene

Phenotypes From GWAS Catalog for TMEM263 Gene

genes like me logo Genes that share phenotypes with TMEM263: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM263 - Now 50% OFF >
  • * TMEM263 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM263 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM263 Gene

Localization for TMEM263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM263 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM263 gene
Compartment Confidence
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM263: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM263 Gene

Pathways & Interactions for TMEM263 Gene

PathCards logo

SuperPathways for TMEM263 Gene

No Data Available

Interacting Proteins for TMEM263 Gene

Gene Ontology (GO) - Biological Process for TMEM263 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM263 Gene

Drugs & Compounds for TMEM263 Gene

No Compound Related Data Available

Transcripts for TMEM263 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM263 - Now 50% OFF >
  • * TMEM263 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM263 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM263 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -

Relevant External Links for TMEM263 Gene

GeneLoc Exon Structure for
TMEM263
ECgene alternative splicing isoforms for
TMEM263

Expression for TMEM263 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM263 Gene

Protein differential expression in normal tissues from HIPED for TMEM263 Gene

This gene is overexpressed in Heart (12.5) and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM263 Gene



Protein tissue co-expression partners for TMEM263 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM263 Gene:

TMEM263

Evidence on tissue expression from TISSUES for TMEM263 Gene

  • Skin(4.3)
  • Nervous system(3.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with TMEM263: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM263 Gene

Orthologs for TMEM263 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM263 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf23 35
  • 100 (a)
OneToOne
C12H12orf23 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia C12orf23 35
  • 97 (a)
OneToOne
C10H12orf23 34
  • 96.81 (n)
cow
(Bos Taurus)
Mammalia C5H12orf23 35 34
  • 96.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563325 34
  • 95.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C12orf23 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf23 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI597468 35 34
  • 94.78 (n)
OneToOne
Tmem263 17
chicken
(Gallus gallus)
Aves C1H12ORF23 35 34
  • 84.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf23 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75626 34 34
  • 73.68 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64098 34
  • 73.28 (n)
C18H12orf23 35
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5400 34
Species where no ortholog for TMEM263 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM263 Gene

ENSEMBL:
Gene Tree for TMEM263 (if available)
TreeFam:
Gene Tree for TMEM263 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM263: view image

Paralogs for TMEM263 Gene

No data available for Paralogs for TMEM263 Gene

Variants for TMEM263 Gene

Sequence variations from dbSNP and Humsavar for TMEM263 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000017557 -- 106,965,092(+) C/G/T intron_variant
rs1000205854 -- 106,965,558(+) A/G intron_variant
rs1000338077 -- 106,968,307(+) C/T intron_variant
rs1000391548 -- 106,968,756(+) T/C intron_variant
rs1000399155 -- 106,961,255(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM263 Gene

Variant ID Type Subtype PubMed ID
dgv99n21 CNV loss 19592680
esv3411246 CNV insertion 20981092
nsv437155 CNV loss 16327808
nsv516865 CNV loss 19592680
nsv9005 CNV gain 18304495

Variation tolerance for TMEM263 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM263 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM263 Gene

Disorders for TMEM263 Gene

Additional Disease Information for TMEM263

No disorders were found for TMEM263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM263 Gene

Publications for TMEM263 Gene

  1. A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chicken. (PMID: 29930570) Wu Z … Crooijmans RPMA (Frontiers in genetics 2018) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma. (PMID: 29331416) Zhu R … Liu Z (Cancer letters 2018) 3 58
  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 58

Products for TMEM263 Gene

Sources for TMEM263 Gene

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