Aliases for TMEM259 Gene

Aliases for TMEM259 Gene

  • Transmembrane Protein 259 2 3 4 5
  • Membralin 2 3 4
  • Aspecific BCL2 ARE-Binding Protein 1 2 3
  • ASBABP1 2 3
  • C19orf6 3 4
  • MBRL 2 3
  • Chromosome 19 Open Reading Frame 6 2
  • R32184_3 3
  • TMEM259 5
  • MGC4022 2

External Ids for TMEM259 Gene

Previous HGNC Symbols for TMEM259 Gene

  • C19orf6

Previous GeneCards Identifiers for TMEM259 Gene

  • GC19M001006

Summaries for TMEM259 Gene

GeneCards Summary for TMEM259 Gene

TMEM259 (Transmembrane Protein 259) is a Protein Coding gene. An important paralog of this gene is NUF2.

UniProtKB/Swiss-Prot Summary for TMEM259 Gene

  • May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

Additional gene information for TMEM259 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM259 Gene

Genomics for TMEM259 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM259 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM259 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM259

Genomic Locations for TMEM259 Gene

Genomic Locations for TMEM259 Gene
11,532 bases
Minus strand
11,495 bases
Minus strand

Genomic View for TMEM259 Gene

Genes around TMEM259 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM259 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM259 Gene

Proteins for TMEM259 Gene

  • Protein details for TMEM259 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O60392
    • Q8NF79
    • Q96H30

    Protein attributes for TMEM259 Gene

    620 amino acids
    Molecular mass:
    67889 Da
    Quaternary structure:
    • Interacts with ERLIN2.
    • Sequence=AAC12681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM259 Gene


neXtProt entry for TMEM259 Gene

Post-translational modifications for TMEM259 Gene

  • Glycosylation at Asn189
  • Ubiquitination at Lys280
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM259 Gene

Domains & Families for TMEM259 Gene

Gene Families for TMEM259 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM259 Gene


Suggested Antigen Peptide Sequences for TMEM259 Gene

GenScript: Design optimal peptide antigens:
  • Membralin (MBRL_HUMAN)
  • Aspecific BCL2 ARE-binding protein 1 (Q8IWT9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the membralin family.
  • Belongs to the membralin family.
genes like me logo Genes that share domains with TMEM259: view

Function for TMEM259 Gene

Molecular function for TMEM259 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

Phenotypes From GWAS Catalog for TMEM259 Gene

genes like me logo Genes that share phenotypes with TMEM259: view

Animal Model Products

CRISPR Products

miRNA for TMEM259 Gene

miRTarBase miRNAs that target TMEM259

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM259

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM259 Gene

Localization for TMEM259 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM259 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM259 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM259: view

Pathways & Interactions for TMEM259 Gene

PathCards logo

SuperPathways for TMEM259 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IBA 21873635
GO:1901215 negative regulation of neuron death IEA --
GO:1904294 positive regulation of ERAD pathway IBA 21873635
genes like me logo Genes that share ontologies with TMEM259: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM259 Gene

Drugs & Compounds for TMEM259 Gene

No Compound Related Data Available

Transcripts for TMEM259 Gene

mRNA/cDNA for TMEM259 Gene

6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM259

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for TMEM259 Gene

GeneLoc Exon Structure for

Expression for TMEM259 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM259 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM259 Gene

This gene is overexpressed in Urine (36.8) and Pancreas (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM259 Gene

Protein tissue co-expression partners for TMEM259 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM259

SOURCE GeneReport for Unigene cluster for TMEM259 Gene:


Evidence on tissue expression from TISSUES for TMEM259 Gene

  • Muscle(4.5)
  • Liver(4.4)
  • Spleen(4.4)
  • Nervous system(4.1)
  • Lung(3)
  • Kidney(2.6)
  • Skin(2.4)
  • Intestine(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TMEM259: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM259 Gene

Orthologs for TMEM259 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM259 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM259 31
  • 97 (a)
C19H19orf6 30
  • 96.95 (n)
(Canis familiaris)
Mammalia TMEM259 31
  • 89 (a)
C20H19orf6 30
  • 86.43 (n)
(Bos Taurus)
Mammalia TMEM259 30 31
  • 86.58 (n)
(Rattus norvegicus)
Mammalia Mbrl 30
  • 84.93 (n)
(Mus musculus)
Mammalia Tmem259 30 17 31
  • 84.5 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM259 31
  • 74 (a)
(Monodelphis domestica)
Mammalia TMEM259 31
  • 71 (a)
(Gallus gallus)
Aves C19ORF6 30
  • 74.07 (n)
TMEM259 31
  • 72 (a)
(Anolis carolinensis)
Reptilia TMEM259 31
  • 96 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem259 30
  • 70.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14528 30
(Danio rerio)
Actinopterygii tmem259 30 31
  • 71.41 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8405 31
  • 27 (a)
(Caenorhabditis elegans)
Secernentea Y59C2A.2 31
  • 35 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
Species where no ortholog for TMEM259 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM259 Gene

Gene Tree for TMEM259 (if available)
Gene Tree for TMEM259 (if available)
Evolutionary constrained regions (ECRs) for TMEM259: view image

Paralogs for TMEM259 Gene

Paralogs for TMEM259 Gene

genes like me logo Genes that share paralogs with TMEM259: view

Variants for TMEM259 Gene

Additional dbSNP identifiers (rs#s) for TMEM259 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM259 Gene

Variant ID Type Subtype PubMed ID
dgv135n111 CNV deletion 26073780
esv2758743 CNV gain+loss 17122850
esv3643383 CNV gain 21293372
esv3643384 CNV loss 21293372
esv3643385 CNV gain 21293372
nsv1160555 CNV deletion 26073780
nsv469845 CNV loss 16826518
nsv578188 CNV loss 21841781
nsv578189 CNV loss 21841781
nsv828360 CNV loss 20364138
nsv833704 CNV gain 17160897
nsv953938 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for TMEM259 Gene

Gene Damage Index Score: 3.61; 56.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM259 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM259 Gene

Disorders for TMEM259 Gene

No disorders were found for TMEM259 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM259 Gene

Publications for TMEM259 Gene

  1. Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma. (PMID: 16084606) Chen YC … Shih IeM (Biochimica et biophysica acta 2005) 2 3 4 23
  2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PMID: 12638133) Andersson O … von Euler G (Brain research. Gene expression patterns 2002) 2 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

Products for TMEM259 Gene

Sources for TMEM259 Gene