Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM258 Gene

Aliases for TMEM258 Gene

  • Transmembrane Protein 258 2 3 5
  • C11orf10 3 4
  • UPF0197 Transmembrane Protein C11orf10 3
  • Chromosome 11 Open Reading Frame 10 2

External Ids for TMEM258 Gene

Previous HGNC Symbols for TMEM258 Gene

  • C11orf10

Previous GeneCards Identifiers for TMEM258 Gene

  • GC11M061557

Summaries for TMEM258 Gene

GeneCards Summary for TMEM258 Gene

TMEM258 (Transmembrane Protein 258) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM258 Gene

  • Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation (PubMed:26472760, PubMed:27974209). Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity).

Additional gene information for TMEM258 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM258 Gene

Genomics for TMEM258 Gene

GeneHancer (GH) Regulatory Elements for TMEM258 Gene

Promoters and enhancers for TMEM258 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I061791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 77 3.1 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B FADS2 FEN1 MIR611 TMEM258 CPSF7 CSKMT GANAB TMEM138 EML3 TUT1
GH11I061731 Enhancer 1.1 Ensembl ENCODE 11.6 +59.8 59833 2.1 PKNOX1 CLOCK ATF1 ARNT ARID4B SIN3A BRCA1 ZNF48 ZNF143 ATF7 DAGLA MYRF DKFZP434K028 FEN1 MIR611 TMEM258 SYT7 PIR41833
GH11I061819 Enhancer 0.9 Ensembl ENCODE 10.7 -27.8 -27764 1.7 KLF1 RXRA MAFG ZNF592 FOSL1 ZNF316 ATF3 SCRT2 HNF4G FOSL2 FADS2 FEN1 TMEM258 MIR611 MIR1908 PIR43939 FADS1
GH11I061787 Enhancer 0.9 ENCODE dbSUPER 0.8 +4.4 4405 0.9 CTCF USF1 ARID4B RAD21 TEAD3 POLR2B ARID2 ZNF143 ZNF444 BHLHE40 FADS2 CPSF7 TUT1 CSKMT TMEM138 RN7SL23P MTA2 INTS5 GANAB TAF6L
GH11I061774 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +16.4 16443 3.3 RB1 ZSCAN4 RAD21 EGR1 ARID2 ZNF143 DEK EGR2 CEBPB REST FADS2 TMEM258 MIR611 GC11P061758 MYRF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM258 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM258 Gene

Genomic Locations for TMEM258 Gene
chr11:61,768,501-61,792,802
(GRCh38/hg38)
Size:
24,302 bases
Orientation:
Minus strand
chr11:61,535,973-61,560,274
(GRCh37/hg19)

Genomic View for TMEM258 Gene

Genes around TMEM258 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM258 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM258 Gene

Proteins for TMEM258 Gene

  • Protein details for TMEM258 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61165-TM258_HUMAN
    Recommended name:
    Transmembrane protein 258
    Protein Accession:
    P61165
    Secondary Accessions:
    • A8K6L8
    • Q9D953
    • Q9Y2Q7

    Protein attributes for TMEM258 Gene

    Size:
    79 amino acids
    Molecular mass:
    9079 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. In the OST complex interacts with RPN1.

neXtProt entry for TMEM258 Gene

Post-translational modifications for TMEM258 Gene

No Post-translational modifications

Other Protein References for TMEM258 Gene

No data available for DME Specific Peptides for TMEM258 Gene

Domains & Families for TMEM258 Gene

Gene Families for TMEM258 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM258 Gene

Suggested Antigen Peptide Sequences for TMEM258 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61165

UniProtKB/Swiss-Prot:

TM258_HUMAN :
  • Belongs to the TMEM258 family.
Family:
  • Belongs to the TMEM258 family.
genes like me logo Genes that share domains with TMEM258: view

Function for TMEM258 Gene

Molecular function for TMEM258 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation (PubMed:26472760, PubMed:27974209). Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity).

Phenotypes From GWAS Catalog for TMEM258 Gene

genes like me logo Genes that share phenotypes with TMEM258: view

Animal Models for TMEM258 Gene

MGI Knock Outs for TMEM258:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM258 Gene

Localization for TMEM258 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM258 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM258 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2
extracellular 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM258 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 26472760
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034998 oligosaccharyltransferase I complex IDA,IEA 26472760
genes like me logo Genes that share ontologies with TMEM258: view

Pathways & Interactions for TMEM258 Gene

SuperPathways for TMEM258 Gene

No Data Available

UniProtKB/Swiss-Prot P61165-TM258_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for TMEM258 Gene

Gene Ontology (GO) - Biological Process for TMEM258 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation IEA,IMP 26472760
genes like me logo Genes that share ontologies with TMEM258: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM258 Gene

Drugs & Compounds for TMEM258 Gene

No Compound Related Data Available

Transcripts for TMEM258 Gene

mRNA/cDNA for TMEM258 Gene

Unigene Clusters for TMEM258 Gene

Transmembrane protein 258:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM258 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM258 Gene

GeneLoc Exon Structure for
TMEM258
ECgene alternative splicing isoforms for
TMEM258

Expression for TMEM258 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM258 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM258 Gene

This gene is overexpressed in Pancreas (18.9) and Gallbladder (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM258 Gene



Protein tissue co-expression partners for TMEM258 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM258 Gene:

TMEM258

SOURCE GeneReport for Unigene cluster for TMEM258 Gene:

Hs.437779

mRNA Expression by UniProt/SwissProt for TMEM258 Gene:

P61165-TM258_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TMEM258 Gene

  • Nervous system(4.4)
  • Blood(4.1)
  • Heart(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with TMEM258: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM258 Gene

Orthologs for TMEM258 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM258 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM258 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM258 34
  • 100 (a)
OneToOne
C11H11orf10 33
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
TMEM258 33
  • 94.94 (n)
C11ORF10 34
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem258 33 16 34
  • 91.98 (n)
cow
(Bos Taurus)
Mammalia TMEM258 33 34
  • 90.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM258 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM258 34
  • 100 (a)
OneToOne
C5H11ORF10 33
  • 85.65 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM258 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem258 33
  • 81.01 (n)
Str.6254 33
zebrafish
(Danio rerio)
Actinopterygii tmem258 33 34
  • 77.64 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005935 33
  • 63.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9669 33 34
  • 61.4 (n)
worm
(Caenorhabditis elegans)
Secernentea Y57E12AM.1 34
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8385 34
  • 65 (a)
OneToOne
Species where no ortholog for TMEM258 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM258 Gene

ENSEMBL:
Gene Tree for TMEM258 (if available)
TreeFam:
Gene Tree for TMEM258 (if available)

Paralogs for TMEM258 Gene

Pseudogenes.org Pseudogenes for TMEM258 Gene

genes like me logo Genes that share paralogs with TMEM258: view

No data available for Paralogs for TMEM258 Gene

Variants for TMEM258 Gene

Sequence variations from dbSNP and Humsavar for TMEM258 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000681634 -- 61,789,451(-) C/T intron_variant
rs1000754972 -- 61,789,019(-) T/A/C downstream_transcript_variant
rs1001095074 -- 61,789,153(-) G/A 3_prime_UTR_variant
rs1002302862 -- 61,789,564(-) T/C intron_variant
rs1002676540 -- 61,792,969(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM258 Gene

Variant ID Type Subtype PubMed ID
nsv343 CNV insertion 18451855
nsv528697 CNV loss 19592680

Variation tolerance for TMEM258 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM258 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM258

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM258 Gene

Disorders for TMEM258 Gene

Additional Disease Information for TMEM258

No disorders were found for TMEM258 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM258 Gene

Publications for TMEM258 Gene

  1. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  4. Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus. (PMID: 12427278) Adachi N … Lieber MR (Omics : a journal of integrative biology 2002) 2 3 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for TMEM258 Gene

Sources for TMEM258 Gene

Content
Loading form....