Aliases for TMEM256 Gene

Aliases for TMEM256 Gene

  • Transmembrane Protein 256 2 3 4 5
  • C17orf61 3 4
  • Chromosome 17 Open Reading Frame 61 2
  • UPF0451 Protein C17orf61 3

External Ids for TMEM256 Gene

Previous HGNC Symbols for TMEM256 Gene

  • C17orf61

Previous GeneCards Identifiers for TMEM256 Gene

  • GC17M007307

Summaries for TMEM256 Gene

GeneCards Summary for TMEM256 Gene

TMEM256 (Transmembrane Protein 256) is a Protein Coding gene. An important paralog of this gene is TMEM256-PLSCR3.

Additional gene information for TMEM256 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM256 Gene

Genomics for TMEM256 Gene

GeneHancer (GH) Regulatory Elements for TMEM256 Gene

Promoters and enhancers for TMEM256 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM256 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM256

Genomic Locations for TMEM256 Gene

Genomic Locations for TMEM256 Gene
chr17:7,402,974-7,404,131
(GRCh38/hg38)
Size:
1,158 bases
Orientation:
Minus strand
chr17:7,306,293-7,307,456
(GRCh37/hg19)
Size:
1,164 bases
Orientation:
Minus strand

Genomic View for TMEM256 Gene

Genes around TMEM256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM256 Gene

Proteins for TMEM256 Gene

  • Protein details for TMEM256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2U0-TM256_HUMAN
    Recommended name:
    Transmembrane protein 256
    Protein Accession:
    Q8N2U0

    Protein attributes for TMEM256 Gene

    Size:
    113 amino acids
    Molecular mass:
    11742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM256 Gene

Post-translational modifications for TMEM256 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM256 Gene

Domains & Families for TMEM256 Gene

Gene Families for TMEM256 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM256 Gene

Blocks:
  • Protein of unknown function DUF423
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM256 Gene

GenScript: Design optimal peptide antigens:
  • UPF0451 protein C17orf61 (CQ061_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N2U0

UniProtKB/Swiss-Prot:

TM256_HUMAN :
  • Belongs to the TMEM256 family.
Family:
  • Belongs to the TMEM256 family.
genes like me logo Genes that share domains with TMEM256: view

Function for TMEM256 Gene

Phenotypes From GWAS Catalog for TMEM256 Gene

Gene Ontology (GO) - Molecular Function for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM256: view
genes like me logo Genes that share phenotypes with TMEM256: view

Animal Models for TMEM256 Gene

MGI Knock Outs for TMEM256:

Animal Model Products

CRISPR Products

miRNA for TMEM256 Gene

miRTarBase miRNAs that target TMEM256

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM256

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM256 Gene

Localization for TMEM256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM256 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM256 gene
Compartment Confidence
extracellular 2
mitochondrion 1
plasma membrane 0
nucleus 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with TMEM256: view

Pathways & Interactions for TMEM256 Gene

PathCards logo

SuperPathways for TMEM256 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM256: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM256 Gene

Drugs & Compounds for TMEM256 Gene

No Compound Related Data Available

Transcripts for TMEM256 Gene

mRNA/cDNA for TMEM256 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM256

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM256 Gene

No ASD Table

Relevant External Links for TMEM256 Gene

GeneLoc Exon Structure for
TMEM256

Expression for TMEM256 Gene

Protein differential expression in normal tissues from HIPED for TMEM256 Gene

This gene is overexpressed in Urine (37.9) and Nasal epithelium (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM256 Gene



Protein tissue co-expression partners for TMEM256 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM256

SOURCE GeneReport for Unigene cluster for TMEM256 Gene:

Hs.730789

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM256 Gene

Orthologs for TMEM256 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM256 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM256 30
  • 99.41 (n)
-- 31
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
TMEM256 30
  • 89.68 (n)
cow
(Bos Taurus)
Mammalia TMEM256 31 30
  • 89.56 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem256 17 31 30
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Tmem256 30
  • 87.07 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem256 31 30
  • 57.45 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42395 31
  • 23 (a)
ManyToMany
CG4686 31
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6H.8 31
  • 26 (a)
OneToMany
Species where no ortholog for TMEM256 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM256 Gene

ENSEMBL:
Gene Tree for TMEM256 (if available)
TreeFam:
Gene Tree for TMEM256 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM256: view image

Paralogs for TMEM256 Gene

Paralogs for TMEM256 Gene

Pseudogenes.org Pseudogenes for TMEM256 Gene

genes like me logo Genes that share paralogs with TMEM256: view

Variants for TMEM256 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM256 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs886039795 Likely Pathogenic: Short-rib thoracic dysplasia 3 with or without polydactyly 7,403,142(-) CCACTCAGAGCCTGGT FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM256 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM256 Gene

Variant ID Type Subtype PubMed ID
esv1007381 CNV deletion 20482838
esv2422288 CNV deletion 17116639
esv2662967 CNV deletion 23128226
nsv457659 CNV loss 19166990
nsv470575 CNV loss 18288195
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for TMEM256 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM256 Gene

Human Gene Mutation Database (HGMD)
TMEM256
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM256 Gene

Disorders for TMEM256 Gene

Additional Disease Information for TMEM256

No disorders were found for TMEM256 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM256 Gene

Publications for TMEM256 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  3. Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation. (PMID: 27664330) Wang L … Llorente A (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017) 3 54
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 54
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 54

Products for TMEM256 Gene

Sources for TMEM256 Gene