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Aliases for TMEM254 Gene

Aliases for TMEM254 Gene

  • Transmembrane Protein 254 2 3 5
  • C10orf57 3 4
  • Chromosome 10 Open Reading Frame 57 2
  • Transmembrane Protein C10orf57 3
  • BA369J21.6 3

External Ids for TMEM254 Gene

Previous HGNC Symbols for TMEM254 Gene

  • C10orf57

Previous GeneCards Identifiers for TMEM254 Gene

  • GC10P081838

Summaries for TMEM254 Gene

GeneCards Summary for TMEM254 Gene

TMEM254 (Transmembrane Protein 254) is a Protein Coding gene.

Additional gene information for TMEM254 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM254 Gene

Genomics for TMEM254 Gene

GeneHancer (GH) Regulatory Elements for TMEM254 Gene

Promoters and enhancers for TMEM254 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I080077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.2 +0.3 257 2.6 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 SP3 SP5 TMEM254-AS1 TMEM254 ANXA11 LINC00857
GH10I080076 Enhancer 0.2 ENCODE 563.2 -1.8 -1826 0.2 TMEM254 ANXA11 LINC00857 TMEM254-AS1 GC10P081715
GH10I080103 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +26.4 26436 3.5 RFX1 RFX3 MAFK TMEM254-AS1 TMEM254 SFTPD PIR41694 ENSG00000279399
GH10I080109 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.5 +31.9 31932 1.5 SOX13 ZNF48 TEAD3 ZNF335 GATA3 NR2F6 MIXL1 GATAD2A SOX5 NFIA TMEM254-AS1 TMEM254 SFTPD PIR41694 RPL22P18
GH10I080100 Enhancer 0.6 ENCODE 12.8 +22.3 22325 1.3 SMARCE1 PKNOX1 DPF2 ZNF217 GATA3 CTBP1 CREB1 FOS TMEM254-AS1 MBL1P TMEM254 ANXA11 LINC00857 SFTPD ENSG00000279399 PIR41694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM254 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM254 Gene

Genomic Locations for TMEM254 Gene
chr10:80,078,646-80,092,557
(GRCh38/hg38)
Size:
13,912 bases
Orientation:
Plus strand
chr10:81,838,402-81,852,313
(GRCh37/hg19)

Genomic View for TMEM254 Gene

Genes around TMEM254 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM254 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM254 Gene

Proteins for TMEM254 Gene

  • Protein details for TMEM254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBM7-TM254_HUMAN
    Recommended name:
    Transmembrane protein 254
    Protein Accession:
    Q8TBM7
    Secondary Accessions:
    • D3DWC8
    • Q53HP4
    • Q5JTC0
    • Q5JTC1
    • Q6IA45
    • Q9H8S6

    Protein attributes for TMEM254 Gene

    Size:
    123 amino acids
    Molecular mass:
    14243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM254 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM254 Gene

Post-translational modifications for TMEM254 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM254 Gene

Domains & Families for TMEM254 Gene

Gene Families for TMEM254 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM254 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM254: view

No data available for UniProtKB/Swiss-Prot for TMEM254 Gene

Function for TMEM254 Gene

Phenotypes From GWAS Catalog for TMEM254 Gene

genes like me logo Genes that share phenotypes with TMEM254: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM254 Gene

Localization for TMEM254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM254 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM254 gene
Compartment Confidence
extracellular 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM254: view

Pathways & Interactions for TMEM254 Gene

SuperPathways for TMEM254 Gene

No Data Available

Interacting Proteins for TMEM254 Gene

Selected Interacting proteins: Q8TBM7-TM254_HUMAN for TMEM254 Gene via UniProtKB

Symbol External ID(s) Details
FKBP8

Gene Ontology (GO) - Biological Process for TMEM254 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM254 Gene

Drugs & Compounds for TMEM254 Gene

No Compound Related Data Available

Transcripts for TMEM254 Gene

Unigene Clusters for TMEM254 Gene

Transmembrane protein 254:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM254 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9:
SP10: -

Relevant External Links for TMEM254 Gene

GeneLoc Exon Structure for
TMEM254
ECgene alternative splicing isoforms for
TMEM254

Expression for TMEM254 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM254 Gene

Protein differential expression in normal tissues from HIPED for TMEM254 Gene

This gene is overexpressed in Pancreas (13.6), Retina (11.5), CD8 Tcells (9.3), Liver (7.3), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM254 Gene



Protein tissue co-expression partners for TMEM254 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM254 Gene:

TMEM254

SOURCE GeneReport for Unigene cluster for TMEM254 Gene:

Hs.169982

Evidence on tissue expression from TISSUES for TMEM254 Gene

  • Nervous system(4.4)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with TMEM254: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM254 Gene

Orthologs for TMEM254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM254 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM254 34
  • 100 (a)
OneToOne
C10H10orf57 33
  • 99.46 (n)
rat
(Rattus norvegicus)
Mammalia Fam213a 33
  • 83.74 (n)
cow
(Bos Taurus)
Mammalia TMEM254 33 34
  • 79.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM254 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM254 34
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem254a 34
  • 64 (a)
OneToMany
Tmem254b 34
  • 64 (a)
OneToMany
Tmem254c 34
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM254 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF57 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam213a 33
  • 59.84 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64043 33
  • 59.29 (n)
TMEM254 34
  • 47 (a)
OneToOne
Species where no ortholog for TMEM254 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM254 Gene

ENSEMBL:
Gene Tree for TMEM254 (if available)
TreeFam:
Gene Tree for TMEM254 (if available)

Paralogs for TMEM254 Gene

genes like me logo Genes that share paralogs with TMEM254: view

No data available for Paralogs for TMEM254 Gene

Variants for TMEM254 Gene

Sequence variations from dbSNP and Humsavar for TMEM254 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000074625 -- 80,089,500(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000428633 -- 80,078,739(+) A/C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1001749771 -- 80,077,987(+) C/G upstream_transcript_variant
rs1002135010 -- 80,077,185(+) C/T upstream_transcript_variant
rs1002331003 -- 80,082,699(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM254 Gene

Variant ID Type Subtype PubMed ID
dgv941n100 CNV gain 25217958
esv3623939 CNV loss 21293372
esv3623940 CNV loss 21293372
nsv819306 CNV loss 19587683
nsv551635 CNV loss 21841781
nsv1141879 OTHER inversion 24896259
esv3623943 CNV gain 21293372
esv3623942 CNV loss 21293372
esv3623941 CNV gain 21293372

Variation tolerance for TMEM254 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM254 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM254

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM254 Gene

Disorders for TMEM254 Gene

Additional Disease Information for TMEM254

No disorders were found for TMEM254 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM254 Gene

Publications for TMEM254 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (PMID: 23144326) Kim DK … ECLIPSE, ICGN, and COPDGene Investigators (American journal of respiratory and critical care medicine 2012) 3 58

Products for TMEM254 Gene

Sources for TMEM254 Gene

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