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Aliases for TMEM253 Gene

Aliases for TMEM253 Gene

  • Transmembrane Protein 253 2 3 5
  • C14orf176 3 4
  • C14orf95 3 4
  • Chromosome 14 Open Reading Frame 176 2
  • Chromosome 14 Open Reading Frame 95 2
  • Transmembrane Protein C14orf176 3
  • Non-Protein Coding RNA 220 2
  • NCRNA00220 3

External Ids for TMEM253 Gene

Previous HGNC Symbols for TMEM253 Gene

  • NCRNA00220
  • C14orf95
  • C14orf176

Previous GeneCards Identifiers for TMEM253 Gene

  • GC14P021567

Summaries for TMEM253 Gene

GeneCards Summary for TMEM253 Gene

TMEM253 (Transmembrane Protein 253) is a Protein Coding gene.

Additional gene information for TMEM253 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM253 Gene

Genomics for TMEM253 Gene

GeneHancer (GH) Regulatory Elements for TMEM253 Gene

Promoters and enhancers for TMEM253 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021092 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +2.5 2489 18.3 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TMEM253 ZNF219 METTL3 METTL17 SUPT16H CHD8 TEP1 APEX1 PNP ARHGEF40
GH14I021068 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 -27.9 -27892 5 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF213 E2F8 ZNF143 FOS PAF1 ARHGEF40 NDRG2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13 RNASE6 TOX4
GH14I020997 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.6 -100.3 -100252 2.9 KLF17 ZIC2 POLR2A SCRT2 PRDM10 ZNF600 FOS KLF8 SCRT1 SMARCC1 SLC39A2 LOC101929718 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 METTL17
GH14I020954 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 9.9 -143.5 -143536 1.6 GATAD2A NFIA HLF CEBPB CEBPG POLR2A CEBPA HNF4G HNF4A RNASE2 ENSG00000136315 METTL17 SLC39A2 RNASE1 ZNF219 TMEM253 LOC100507513
GH14I021014 Enhancer 1.1 Ensembl ENCODE 10.9 -83.6 -83630 1.6 PKNOX1 FOXA2 ARID4B SIN3A IRF4 ARID2 ZNF143 DEK RXRA NCOA1 RNASE7 ARHGEF40 NDRG2 ZNF219 METTL17 TMEM253 GC14M021020 GC14P021091
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM253 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM253 Gene

Genomic Locations for TMEM253 Gene
chr14:21,098,937-21,103,724
(GRCh38/hg38)
Size:
4,788 bases
Orientation:
Plus strand
chr14:21,567,096-21,571,883
(GRCh37/hg19)

Genomic View for TMEM253 Gene

Genes around TMEM253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM253 Gene

Proteins for TMEM253 Gene

  • Protein details for TMEM253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7T8-TM253_HUMAN
    Recommended name:
    Transmembrane protein 253
    Protein Accession:
    P0C7T8

    Protein attributes for TMEM253 Gene

    Size:
    217 amino acids
    Molecular mass:
    23522 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM253 Gene

Post-translational modifications for TMEM253 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM253 Gene

Domains & Families for TMEM253 Gene

Gene Families for TMEM253 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM253 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM253: view

No data available for UniProtKB/Swiss-Prot for TMEM253 Gene

Function for TMEM253 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM253 Gene

Localization for TMEM253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM253 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM253 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM253: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM253 Gene

Pathways & Interactions for TMEM253 Gene

SuperPathways for TMEM253 Gene

No Data Available

Interacting Proteins for TMEM253 Gene

Selected Interacting proteins: P0C7T8-TM253_HUMAN for TMEM253 Gene via IID

Symbol External ID(s) Details
RAPGEF5
TUBA1B

Gene Ontology (GO) - Biological Process for TMEM253 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM253 Gene

Drugs & Compounds for TMEM253 Gene

No Compound Related Data Available

Transcripts for TMEM253 Gene

mRNA/cDNA for TMEM253 Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM253 Gene

Transmembrane protein 253:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM253 Gene

No ASD Table

Relevant External Links for TMEM253 Gene

GeneLoc Exon Structure for
TMEM253
ECgene alternative splicing isoforms for
TMEM253

Expression for TMEM253 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM253 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM253 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.2) and Colon - Transverse (x12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM253 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM253 Gene:

TMEM253

SOURCE GeneReport for Unigene cluster for TMEM253 Gene:

Hs.540107
genes like me logo Genes that share expression patterns with TMEM253: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM253 Gene

Orthologs for TMEM253 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM253 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14ORF176 34
  • 100 (a)
OneToOne
TMEM253 33
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia TMEM253 33 34
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia TMEM253 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem253 33
  • 81.24 (n)
mouse
(Mus musculus)
Mammalia Tmem253 33 16 34
  • 80.57 (n)
Species where no ortholog for TMEM253 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM253 Gene

ENSEMBL:
Gene Tree for TMEM253 (if available)
TreeFam:
Gene Tree for TMEM253 (if available)

Paralogs for TMEM253 Gene

No data available for Paralogs for TMEM253 Gene

Variants for TMEM253 Gene

Sequence variations from dbSNP and Humsavar for TMEM253 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000157852 -- 21,099,224(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000195848 -- 21,101,178(+) A/C 5_prime_UTR_variant
rs1000510519 -- 21,098,894(+) C/T upstream_transcript_variant
rs1000630471 -- 21,097,344(+) ATGGGG/ATGGGGGGGATGGGG upstream_transcript_variant
rs1000708801 -- 21,103,235(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM253 Gene

Variant ID Type Subtype PubMed ID
dgv123n21 CNV loss 19592680
nsv826882 CNV gain 20364138

Variation tolerance for TMEM253 Gene

Gene Damage Index Score: 1.58; 30.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM253 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM253 Gene

Disorders for TMEM253 Gene

Additional Disease Information for TMEM253

No disorders were found for TMEM253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM253 Gene

Publications for TMEM253 Gene

  1. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier LD … Marra M (Genome research 1996) 3 58

Products for TMEM253 Gene

Sources for TMEM253 Gene

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