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Aliases for TMEM251 Gene

Aliases for TMEM251 Gene

  • Transmembrane Protein 251 2 3 5
  • C14orf109 3 4
  • UPF0694 Transmembrane Protein C14orf109 3
  • Chromosome 14 Open Reading Frame 109 2

External Ids for TMEM251 Gene

Previous HGNC Symbols for TMEM251 Gene

  • C14orf109

Previous GeneCards Identifiers for TMEM251 Gene

  • GC14P093653

Summaries for TMEM251 Gene

GeneCards Summary for TMEM251 Gene

TMEM251 (Transmembrane Protein 251) is a Protein Coding gene.

Additional gene information for TMEM251 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM251 Gene

Genomics for TMEM251 Gene

GeneHancer (GH) Regulatory Elements for TMEM251 Gene

Promoters and enhancers for TMEM251 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I093183 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 64 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B ZNF207 KLF13 MOAP1 ENSG00000259066 TMEM251 BTBD7 GOLGA5 DDX24 UBR7
GH14I093186 Enhancer 0.3 ENCODE 550.8 +1.7 1720 0.2 PKNOX1 ENSG00000259066 TMEM251 MOAP1 UBR7
GH14I092846 Enhancer 1.4 FANTOM5 Ensembl ENCODE 35.9 -337.9 -337851 1.4 HDAC1 ATF1 BATF IRF4 TCF12 EGR1 ATF7 IKZF2 RUNX3 PHF21A TMEM251 CHGA UNC79 RIN3 MOAP1 BTBD7 GON7 PIR36925 GC14P092878 GC14P092880
GH14I092723 Enhancer 1.3 FANTOM5 Ensembl ENCODE 26.7 -459.6 -459610 3.9 HDAC1 ATF1 FOXA2 THRB RARA FOS ATF7 SMARCA5 HMG20B ZNF280D TMEM251 SLC24A4 RIN3 MOAP1 GON7 LGMN GC14P092700 GC14P092353
GH14I093205 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.8 +22.2 22215 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 SLC30A9 POLR2B GON7 UBR7 BTBD7 MOAP1 TMEM251 ENSG00000240096 ENSG00000259066
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM251 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM251 Gene

Genomic Locations for TMEM251 Gene
chr14:93,184,951-93,187,089
(GRCh38/hg38)
Size:
2,139 bases
Orientation:
Plus strand
chr14:93,651,296-93,653,434
(GRCh37/hg19)

Genomic View for TMEM251 Gene

Genes around TMEM251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM251 Gene

Proteins for TMEM251 Gene

  • Protein details for TMEM251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6I4-TM251_HUMAN
    Recommended name:
    Transmembrane protein 251
    Protein Accession:
    Q8N6I4
    Secondary Accessions:
    • J3KQ65
    • Q9Y4S5

    Protein attributes for TMEM251 Gene

    Size:
    163 amino acids
    Molecular mass:
    18747 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM251 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM251 Gene

Post-translational modifications for TMEM251 Gene

No Post-translational modifications

Other Protein References for TMEM251 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM251 Gene

Domains & Families for TMEM251 Gene

Gene Families for TMEM251 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM251 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM251 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6I4

UniProtKB/Swiss-Prot:

TM251_HUMAN :
  • Belongs to the TMEM251 family.
Family:
  • Belongs to the TMEM251 family.
genes like me logo Genes that share domains with TMEM251: view

Function for TMEM251 Gene

Phenotypes From GWAS Catalog for TMEM251 Gene

Phenotypes for TMEM251 Gene

GenomeRNAi human phenotypes for TMEM251:
genes like me logo Genes that share phenotypes with TMEM251: view

Animal Model Products

CRISPR Products

miRNA for TMEM251 Gene

miRTarBase miRNAs that target TMEM251

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM251 Gene

Localization for TMEM251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM251 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM251 gene
Compartment Confidence
plasma membrane 2
golgi apparatus 2
extracellular 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM251: view

Pathways & Interactions for TMEM251 Gene

SuperPathways for TMEM251 Gene

No Data Available

Interacting Proteins for TMEM251 Gene

Gene Ontology (GO) - Biological Process for TMEM251 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM251 Gene

Drugs & Compounds for TMEM251 Gene

No Compound Related Data Available

Transcripts for TMEM251 Gene

mRNA/cDNA for TMEM251 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM251 Gene

Transmembrane protein 251:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM251 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3
SP1: - - -
SP2: -
SP3:

Relevant External Links for TMEM251 Gene

GeneLoc Exon Structure for
TMEM251
ECgene alternative splicing isoforms for
TMEM251

Expression for TMEM251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM251 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM251 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM251 Gene:

TMEM251

SOURCE GeneReport for Unigene cluster for TMEM251 Gene:

Hs.275352

Evidence on tissue expression from TISSUES for TMEM251 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM251: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM251 Gene

Orthologs for TMEM251 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM251 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM251 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia TMEM251 33 34
  • 94.27 (n)
cow
(Bos Taurus)
Mammalia TMEM251 33 34
  • 93.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM251 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM251 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem251 33
  • 90.59 (n)
mouse
(Mus musculus)
Mammalia Tmem251 33 16 34
  • 90.39 (n)
chicken
(Gallus gallus)
Aves TMEM251 33 34
  • 82.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM251 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem251 33
  • 78.21 (n)
Str.4165 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25600 33
zebrafish
(Danio rerio)
Actinopterygii tmem251 33 34
  • 69.74 (n)
wufb01e08 33
Species where no ortholog for TMEM251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM251 Gene

ENSEMBL:
Gene Tree for TMEM251 (if available)
TreeFam:
Gene Tree for TMEM251 (if available)

Paralogs for TMEM251 Gene

Pseudogenes.org Pseudogenes for TMEM251 Gene

genes like me logo Genes that share paralogs with TMEM251: view

No data available for Paralogs for TMEM251 Gene

Variants for TMEM251 Gene

Sequence variations from dbSNP and Humsavar for TMEM251 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000116037 -- 93,185,023(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001228668 -- 93,187,353(+) G/A downstream_transcript_variant
rs1001434329 -- 93,183,483(+) A/G upstream_transcript_variant
rs1001484907 -- 93,183,908(+) C/T upstream_transcript_variant
rs1004292159 -- 93,187,544(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM251 Gene

Variant ID Type Subtype PubMed ID
nsv827032 CNV gain 20364138
nsv827029 CNV gain 20364138
esv3635357 CNV gain 21293372
esv2749028 CNV deletion 23290073

Variation tolerance for TMEM251 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM251 Gene

Disorders for TMEM251 Gene

Additional Disease Information for TMEM251

No disorders were found for TMEM251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM251 Gene

Publications for TMEM251 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM251 Gene

Sources for TMEM251 Gene

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