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Aliases for TMEM245 Gene

Aliases for TMEM245 Gene

  • Transmembrane Protein 245 2 3 3 5
  • Protein CG-2 3 4
  • C9orf5 3 4
  • Chromosome 9 Open Reading Frame 5 2
  • Transmembrane Protein C9orf5 3
  • CG-2 3
  • CG2 3

External Ids for TMEM245 Gene

Previous HGNC Symbols for TMEM245 Gene

  • C9orf5

Previous GeneCards Identifiers for TMEM245 Gene

  • GC09M111778

Summaries for TMEM245 Gene

GeneCards Summary for TMEM245 Gene

TMEM245 (Transmembrane Protein 245) is a Protein Coding gene.

Additional gene information for TMEM245 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM245 Gene

Genomics for TMEM245 Gene

GeneHancer (GH) Regulatory Elements for TMEM245 Gene

Promoters and enhancers for TMEM245 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J109113 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.9 +2.4 2439 9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 TMEM245 FRRS1L ELP1 CTNNAL1 MIR32 ENSG00000199331 FAM206A GC09M109081
GH09J109010 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.4 +107.1 107137 5.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 CTNNAL1 PIR44811 GC09M109014 FRRS1L ELP1 TMEM245 ENSG00000199331 MIR32
GH09J109096 Enhancer 1.3 Ensembl ENCODE dbSUPER 23.6 +20.0 20047 6.5 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 IRF4 YY1 ATF7 FOS ELP1 CTNNAL1 FRRS1L TMEM245 FAM206A MIR32 ENSG00000199331 GC09M109081
GH09J109128 Enhancer 1.1 ENCODE dbSUPER 12.5 -11.9 -11894 6 ATF1 PKNOX1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 RXRA NCOA1 CTNNAL1 FRRS1L TMEM245 ENSG00000199331 MIR32 RNU6-984P EPB41L4B GC09M109131
GH09J109091 Enhancer 0.5 dbSUPER 23.6 +27.1 27141 2.5 ZNF366 ZNF512 JUNB BATF CTNNAL1 TMEM245 FAM206A ELP1 MIR32 ENSG00000199331 GC09M109081
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM245 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM245 Gene

Genomic Locations for TMEM245 Gene
104,811 bases
Minus strand
104,811 bases
Minus strand

Genomic View for TMEM245 Gene

Genes around TMEM245 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM245 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM245 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM245 Gene

Proteins for TMEM245 Gene

  • Protein details for TMEM245 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 245
    Protein Accession:
    Secondary Accessions:
    • B4DSW7
    • Q5JTQ5
    • Q5SS43
    • Q6ZME3
    • Q8NDJ5
    • Q96CG6

    Protein attributes for TMEM245 Gene

    879 amino acids
    Molecular mass:
    97357 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG43365.1; Type=Frameshift; Positions=872, 878; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM245 Gene


neXtProt entry for TMEM245 Gene

Post-translational modifications for TMEM245 Gene

  • Glycosylation at posLast=575575, posLast=551551, isoforms=2, 3, 4500, and posLast=210210
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM245 Gene

Domains & Families for TMEM245 Gene

Gene Families for TMEM245 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM245 Gene

Suggested Antigen Peptide Sequences for TMEM245 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
  • Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
genes like me logo Genes that share domains with TMEM245: view

Function for TMEM245 Gene

Phenotypes From GWAS Catalog for TMEM245 Gene

Gene Ontology (GO) - Molecular Function for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM245: view
genes like me logo Genes that share phenotypes with TMEM245: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM245

CRISPR Products

miRNA for TMEM245 Gene

miRTarBase miRNAs that target TMEM245

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM245

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM245 Gene

Localization for TMEM245 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM245 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM245 gene
Compartment Confidence
plasma membrane 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10564813
genes like me logo Genes that share ontologies with TMEM245: view

Pathways & Interactions for TMEM245 Gene

SuperPathways for TMEM245 Gene

No Data Available

Interacting Proteins for TMEM245 Gene

Gene Ontology (GO) - Biological Process for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM245: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM245 Gene

Drugs & Compounds for TMEM245 Gene

No Compound Related Data Available

Transcripts for TMEM245 Gene

Unigene Clusters for TMEM245 Gene

Transmembrane protein 245:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM245

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM245 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3: -
SP5: -

Relevant External Links for TMEM245 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM245 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM245 Gene

Protein differential expression in normal tissues from HIPED for TMEM245 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM245 Gene

Protein tissue co-expression partners for TMEM245 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM245 Gene:


SOURCE GeneReport for Unigene cluster for TMEM245 Gene:


mRNA Expression by UniProt/SwissProt for TMEM245 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM245 Gene

  • Eye(4.4)
  • Liver(4.3)
  • Blood(4.1)
  • Nervous system(3.8)
  • Lung(3.6)
  • Kidney(3.3)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with TMEM245: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM245 Gene

Orthologs for TMEM245 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM245 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM245 34 33
  • 99.51 (n)
(Canis familiaris)
Mammalia TMEM245 34 33
  • 91.22 (n)
(Bos Taurus)
Mammalia TMEM245 34 33
  • 90 (n)
(Mus musculus)
Mammalia Tmem245 16 34 33
  • 88.11 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM245 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Tmem245 33
  • 87.8 (n)
(Monodelphis domestica)
Mammalia TMEM245 34
  • 81 (a)
(Gallus gallus)
Aves C2H9ORF5 33
  • 77.68 (n)
TMEM245 34
  • 71 (a)
(Anolis carolinensis)
Reptilia TMEM245 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem245 33
  • 62.73 (n)
(Danio rerio)
Actinopterygii tmem245 34
  • 72 (a)
LOC100000119 33
  • 69.56 (n)
TMEM245 (2 of 2) 34
  • 55 (a)
Dr.14788 33
fruit fly
(Drosophila melanogaster)
Insecta CG2698 34 33
  • 43.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003409 33
  • 43.21 (n)
(Caenorhabditis elegans)
Secernentea M01F1.4 34 33
  • 47.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for TMEM245 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM245 Gene

Gene Tree for TMEM245 (if available)
Gene Tree for TMEM245 (if available)
Evolutionary constrained regions (ECRs) for TMEM245: view image

Paralogs for TMEM245 Gene

No data available for Paralogs for TMEM245 Gene

Variants for TMEM245 Gene

Sequence variations from dbSNP and Humsavar for TMEM245 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000033953 -- 109,105,341(-) A/G intron_variant
rs1000040236 -- 109,069,200(-) T/A intron_variant
rs1000067186 -- 109,038,451(-) C/T intron_variant
rs1000087730 -- 109,118,031(-) G/A intron_variant
rs1000107800 -- 109,093,202(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM245 Gene

Variant ID Type Subtype PubMed ID
esv3621428 CNV loss 21293372
nsv473073 CNV novel sequence insertion 20440878
nsv507526 OTHER sequence alteration 20534489
nsv615148 CNV loss 21841781

Variation tolerance for TMEM245 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.89; 89.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM245 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM245 Gene

Disorders for TMEM245 Gene

Additional Disease Information for TMEM245

No disorders were found for TMEM245 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM245 Gene

Publications for TMEM245 Gene

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. (PMID: 10564813) Chadwick BP … Slaugenhaupt SA (Gene 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM245 Gene

Sources for TMEM245 Gene

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