Aliases for TMEM245 Gene

Aliases for TMEM245 Gene

  • Transmembrane Protein 245 2 3 4 5
  • Protein CG-2 3 4
  • C9orf5 3 4
  • CG-2 2 3
  • Chromosome 9 Open Reading Frame 5 2
  • Transmembrane Protein C9orf5 3
  • TMEM245 5
  • CG2 3

External Ids for TMEM245 Gene

Previous HGNC Symbols for TMEM245 Gene

  • C9orf5

Previous GeneCards Identifiers for TMEM245 Gene

  • GC09M111778

Summaries for TMEM245 Gene

GeneCards Summary for TMEM245 Gene

TMEM245 (Transmembrane Protein 245) is a Protein Coding gene. Diseases associated with TMEM245 include Neuropathy, Hereditary Sensory And Autonomic, Type Iii and Hypermobility Syndrome.

Additional gene information for TMEM245 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM245 Gene

Genomics for TMEM245 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around TMEM245 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM245

Genomic Locations for TMEM245 Gene

Genomic Locations for TMEM245 Gene
chr9:109,015,135-109,119,963
(GRCh38/hg38)
Size:
104,829 bases
Orientation:
Minus strand
chr9:111,777,415-111,882,225
(GRCh37/hg19)
Size:
104,811 bases
Orientation:
Minus strand

Genomic View for TMEM245 Gene

Genes around TMEM245 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM245 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM245 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM245 Gene

Proteins for TMEM245 Gene

  • Protein details for TMEM245 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H330-TM245_HUMAN
    Recommended name:
    Transmembrane protein 245
    Protein Accession:
    Q9H330
    Secondary Accessions:
    • B4DSW7
    • Q5JTQ5
    • Q5SS43
    • Q6ZME3
    • Q8NDJ5
    • Q96CG6

    Protein attributes for TMEM245 Gene

    Size:
    879 amino acids
    Molecular mass:
    97357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43365.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for TMEM245 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM245 Gene

Post-translational modifications for TMEM245 Gene

  • Glycosylation at Asn500, Asn551, Asn575, and Asn210
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TM245_HUMAN (1853)

No data available for DME Specific Peptides for TMEM245 Gene

Domains & Families for TMEM245 Gene

Gene Families for TMEM245 Gene

Protein Domains for TMEM245 Gene

InterPro:
Blocks:
  • Protein of unknown function UPF0118
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM245 Gene

GenScript: Design optimal peptide antigens:
  • Protein CG-2 (CI005_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H330

UniProtKB/Swiss-Prot:

TM245_HUMAN :
  • Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
Family:
  • Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
genes like me logo Genes that share domains with TMEM245: view

Function for TMEM245 Gene

Phenotypes From GWAS Catalog for TMEM245 Gene

Gene Ontology (GO) - Molecular Function for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM245: view
genes like me logo Genes that share phenotypes with TMEM245: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM245

CRISPR Products

miRNA for TMEM245 Gene

miRTarBase miRNAs that target TMEM245

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM245

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM245 Gene

Localization for TMEM245 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM245 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM245 gene
Compartment Confidence
plasma membrane 4
cytosol 2
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10564813
genes like me logo Genes that share ontologies with TMEM245: view

Pathways & Interactions for TMEM245 Gene

PathCards logo

SuperPathways for TMEM245 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM245: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM245 Gene

Drugs & Compounds for TMEM245 Gene

No Compound Related Data Available

Transcripts for TMEM245 Gene

mRNA/cDNA for TMEM245 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM245

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM245 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for TMEM245 Gene

GeneLoc Exon Structure for
TMEM245

Expression for TMEM245 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM245 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM245 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM245 Gene



Protein tissue co-expression partners for TMEM245 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM245

SOURCE GeneReport for Unigene cluster for TMEM245 Gene:

Hs.308074

mRNA Expression by UniProt/SwissProt for TMEM245 Gene:

Q9H330-TM245_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM245 Gene

  • Eye(4.4)
  • Liver(4.3)
  • Blood(4.1)
  • Nervous system(3.8)
  • Lung(3.6)
  • Kidney(3.3)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with TMEM245: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM245 Gene

Orthologs for TMEM245 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM245 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM245 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM245 30 31
  • 91.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM245 30 31
  • 90 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem245 30 17 31
  • 88.11 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM245 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem245 30
  • 87.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM245 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C2H9ORF5 30
  • 77.68 (n)
TMEM245 31
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM245 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem245 30
  • 62.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem245 31
  • 72 (a)
OneToMany
LOC100000119 30
  • 69.56 (n)
TMEM245 (2 of 2) 31
  • 55 (a)
OneToMany
Dr.14788 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG2698 30 31
  • 43.68 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003409 30
  • 43.21 (n)
Worm
(Caenorhabditis elegans)
Secernentea M01F1.4 30 31
  • 47.06 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for TMEM245 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM245 Gene

ENSEMBL:
Gene Tree for TMEM245 (if available)
TreeFam:
Gene Tree for TMEM245 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM245: view image

Paralogs for TMEM245 Gene

No data available for Paralogs for TMEM245 Gene

Variants for TMEM245 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM245 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
776439 Benign: not provided 109,087,295(-) G/A SYNONYMOUS_VARIANT
rs12001627 - p.Asp9Glu
rs2271877 - p.Ala314Thr
rs3750455 - p.Thr787Ala

Additional dbSNP identifiers (rs#s) for TMEM245 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM245 Gene

Variant ID Type Subtype PubMed ID
esv3621428 CNV loss 21293372
nsv473073 CNV novel sequence insertion 20440878
nsv507526 OTHER sequence alteration 20534489
nsv615148 CNV loss 21841781

Variation tolerance for TMEM245 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.89; 89.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM245 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM245

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM245 Gene

Disorders for TMEM245 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM245 Gene - From: DISEASES

Disorder Aliases PubMed IDs
neuropathy, hereditary sensory and autonomic, type iii
  • hsan3
hypermobility syndrome
  • benign joint hypermobility
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMEM245: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM245 Gene

Publications for TMEM245 Gene

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. (PMID: 10564813) Chadwick BP … Slaugenhaupt SA (Gene 1999) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for TMEM245 Gene

Sources for TMEM245 Gene