Aliases for TMEM244 Gene

Aliases for TMEM244 Gene

  • Transmembrane Protein 244 2 3 4 5
  • C6orf191 3 4
  • Putative Transmembrane Protein C6orf191 3
  • Chromosome 6 Open Reading Frame 191 2
  • BA174C7.4 3

External Ids for TMEM244 Gene

Previous HGNC Symbols for TMEM244 Gene

  • C6orf191

Previous GeneCards Identifiers for TMEM244 Gene

  • GC06M130152

Summaries for TMEM244 Gene

GeneCards Summary for TMEM244 Gene

TMEM244 (Transmembrane Protein 244) is a Protein Coding gene. Diseases associated with TMEM244 include Sezary's Disease. An important paralog of this gene is SYS1.

Additional gene information for TMEM244 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM244 Gene

Genomics for TMEM244 Gene

GeneHancer (GH) Regulatory Elements for TMEM244 Gene

Promoters and enhancers for TMEM244 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J129859 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 500.7 +0.6 551 2.2 ZNF384 EZH2 JUND CTCF SMARCA4 POLR2A SIN3A EBF1 MLLT1 CEBPB TMEM244 ARHGAP18 LOC105377999
GH06J129894 Enhancer 0.8 Ensembl ENCODE 16.5 -33.6 -33577 3.4 CTCF REST RAD21 ZNF316 ZNF384 SMC3 JUND ZNF654 TBX21 MAFK TMEM244 L3MBTL3 RPL5P21 piR-32810-111 LOC105377999
GH06J129843 Enhancer 0.8 Ensembl ENCODE 12.8 +17.0 17046 1.4 EP300 USF1 JUND ZNF585B ZNF316 NFIC NUFIP1 ZBTB33 BHLHE40 ZMYM3 TMEM244 LOC105377999 RF00017-5773
GH06J129889 Enhancer 0.8 Ensembl ENCODE 11.3 -28.5 -28518 2.1 JUND FOS CREB1 NR3C1 ZNF592 MEF2B JUN NFE2 FOSL1 ZNF189 TMEM244 L3MBTL3 RPL5P21 piR-32810-111 LOC105377999
GH06J129853 Enhancer 1 Ensembl ENCODE 7.8 +7.1 7096 1.6 FOS ZNF639 TRIM28 HES1 MYC CTBP1 OSR2 HDAC3 NCOR1 BCL11A LOC105377999 TMEM244 RF00017-5773
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM244 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM244

Genomic Locations for TMEM244 Gene

Genomic Locations for TMEM244 Gene
chr6:129,831,244-129,861,547
(GRCh38/hg38)
Size:
30,304 bases
Orientation:
Minus strand
chr6:130,152,389-130,182,692
(GRCh37/hg19)
Size:
30,304 bases
Orientation:
Minus strand

Genomic View for TMEM244 Gene

Genes around TMEM244 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM244 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM244 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM244 Gene

Proteins for TMEM244 Gene

  • Protein details for TMEM244 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVB8-TM244_HUMAN
    Recommended name:
    Transmembrane protein 244
    Protein Accession:
    Q5VVB8

    Protein attributes for TMEM244 Gene

    Size:
    128 amino acids
    Molecular mass:
    14657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM244 Gene

Post-translational modifications for TMEM244 Gene

No Post-translational modifications

Other Protein References for TMEM244 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM244 Gene

Domains & Families for TMEM244 Gene

Gene Families for TMEM244 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM244 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM244 Gene

GenScript: Design optimal peptide antigens:
  • Putative transmembrane protein C6orf191 (CF191_HUMAN)
genes like me logo Genes that share domains with TMEM244: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM244 Gene

Function for TMEM244 Gene

Phenotypes From GWAS Catalog for TMEM244 Gene

genes like me logo Genes that share phenotypes with TMEM244: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM244 Gene

Localization for TMEM244 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM244 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM244 gene
Compartment Confidence
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM244 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM244: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM244 Gene

Pathways & Interactions for TMEM244 Gene

PathCards logo

SuperPathways for TMEM244 Gene

No Data Available

Interacting Proteins for TMEM244 Gene

;

Gene Ontology (GO) - Biological Process for TMEM244 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM244 Gene

Drugs & Compounds for TMEM244 Gene

No Compound Related Data Available

Transcripts for TMEM244 Gene

mRNA/cDNA for TMEM244 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM244 Gene

No ASD Table

Relevant External Links for TMEM244 Gene

GeneLoc Exon Structure for
TMEM244

Expression for TMEM244 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM244 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM244 Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Spinal cord (cervical c-1) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.4), Brain - Hippocampus (x4.4), and Brain - Substantia nigra (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM244

SOURCE GeneReport for Unigene cluster for TMEM244 Gene:

Hs.448372
genes like me logo Genes that share expression patterns with TMEM244: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM244 Gene

Orthologs for TMEM244 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM244 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM244 31 30
  • 98.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100848594 30
  • 85.03 (n)
dog
(Canis familiaris)
Mammalia C1H6orf191 30
  • 83.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM244 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF191 30
  • 71.04 (n)
TMEM244 31
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM244 31
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem244 31 30
  • 56.37 (n)
OneToOne
Species where no ortholog for TMEM244 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM244 Gene

ENSEMBL:
Gene Tree for TMEM244 (if available)
TreeFam:
Gene Tree for TMEM244 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM244: view image

Paralogs for TMEM244 Gene

Paralogs for TMEM244 Gene

genes like me logo Genes that share paralogs with TMEM244: view

Variants for TMEM244 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM244 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs4629709 - p.Phe80Leu
rs7760577 - p.Asn60Ile
rs7776426 - p.Phe111Val
rs9492393 - p.Glu86Gly

Additional dbSNP identifiers (rs#s) for TMEM244 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM244 Gene

Variant ID Type Subtype PubMed ID
esv3610778 CNV gain 21293372
nsv604663 CNV gain 21841781
nsv830805 CNV gain 17160897

Variation tolerance for TMEM244 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.39; 98.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM244 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM244

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM244 Gene

Disorders for TMEM244 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM244 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM244

genes like me logo Genes that share disorders with TMEM244: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM244 Gene

Publications for TMEM244 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54

Products for TMEM244 Gene

Sources for TMEM244 Gene