Aliases for TMEM243 Gene

Aliases for TMEM243 Gene

  • Transmembrane Protein 243 2 3 4 5
  • MDR1- And Mitochondrial Taxol Resistance-Associated Protein 3 4
  • Transmembrane Protein 243, Mitochondrial 2 3
  • C7orf23 3 4
  • MM-TRAG 3 4
  • MDR1 And Mitochondrial Taxol Resistance Associated Gene 2
  • MDR1 And Mitochondrial Taxol Resistance Associated 3
  • Chromosome 7 Open Reading Frame 23 2
  • Transmembrane Protein C7orf23 3
  • MMTRAG 3

External Ids for TMEM243 Gene

Previous HGNC Symbols for TMEM243 Gene

  • C7orf23

Previous GeneCards Identifiers for TMEM243 Gene

  • GC07M086826

Summaries for TMEM243 Gene

GeneCards Summary for TMEM243 Gene

TMEM243 (Transmembrane Protein 243) is a Protein Coding gene.

Additional gene information for TMEM243 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM243 Gene

Genomics for TMEM243 Gene

GeneHancer (GH) Regulatory Elements for TMEM243 Gene

Promoters and enhancers for TMEM243 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM243 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM243

Genomic Locations for TMEM243 Gene

Genomic Locations for TMEM243 Gene
chr7:87,196,160-87,220,587
(GRCh38/hg38)
Size:
24,428 bases
Orientation:
Minus strand
chr7:86,825,478-86,849,903
(GRCh37/hg19)
Size:
24,426 bases
Orientation:
Minus strand

Genomic View for TMEM243 Gene

Genes around TMEM243 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM243 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM243 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM243 Gene

Proteins for TMEM243 Gene

  • Protein details for TMEM243 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU79-TM243_HUMAN
    Recommended name:
    Transmembrane protein 243
    Protein Accession:
    Q9BU79
    Secondary Accessions:
    • A4D1C6
    • B2R9I4
    • D6W5P1

    Protein attributes for TMEM243 Gene

    Size:
    118 amino acids
    Molecular mass:
    13391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM243 Gene

Post-translational modifications for TMEM243 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM243 Gene

Domains & Families for TMEM243 Gene

Gene Families for TMEM243 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM243 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM243 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C7orf23 (CG023_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BU79

UniProtKB/Swiss-Prot:

TM243_HUMAN :
  • Belongs to the TMEM243 family.
Family:
  • Belongs to the TMEM243 family.
genes like me logo Genes that share domains with TMEM243: view

Function for TMEM243 Gene

Phenotypes From GWAS Catalog for TMEM243 Gene

genes like me logo Genes that share phenotypes with TMEM243: view

miRNA for TMEM243 Gene

miRTarBase miRNAs that target TMEM243

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM243 Gene

Localization for TMEM243 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM243 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM243 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM243 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM243: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM243 Gene

Pathways & Interactions for TMEM243 Gene

PathCards logo

SuperPathways for TMEM243 Gene

No Data Available

Interacting Proteins for TMEM243 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000398083 Q9BU79-TM243_HUMAN for TMEM243 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TMEM243 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM243 Gene

Drugs & Compounds for TMEM243 Gene

No Compound Related Data Available

Transcripts for TMEM243 Gene

mRNA/cDNA for TMEM243 Gene

5 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM243 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM243 Gene

GeneLoc Exon Structure for
TMEM243

Expression for TMEM243 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM243 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM243 Gene

This gene is overexpressed in Blymphocyte (58.4) and NK cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM243 Gene



Protein tissue co-expression partners for TMEM243 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM243

SOURCE GeneReport for Unigene cluster for TMEM243 Gene:

Hs.619593

mRNA Expression by UniProt/SwissProt for TMEM243 Gene:

Q9BU79-TM243_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM243 Gene

  • Lung(3.3)
genes like me logo Genes that share expression patterns with TMEM243: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM243 Gene

Orthologs for TMEM243 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM243 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM243 31
  • 100 (a)
OneToOne
C7H7orf23 30
  • 99.72 (n)
mouse
(Mus musculus)
Mammalia Tmem243 17 31 30
  • 94.07 (n)
cow
(Bos Taurus)
Mammalia TMEM243 31 30
  • 94.07 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM243 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM243 31
  • 91 (a)
OneToOne
C14H7orf23 30
  • 86.42 (n)
rat
(Rattus norvegicus)
Mammalia Tmem243 30
  • 90.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM243 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7ORF23 30
  • 82.44 (n)
TMEM243 31
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM243 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem243 30
  • 73.73 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem243b 31 30
  • 70.06 (n)
OneToMany
tmem243a 31
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToOne
Species where no ortholog for TMEM243 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM243 Gene

ENSEMBL:
Gene Tree for TMEM243 (if available)
TreeFam:
Gene Tree for TMEM243 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM243: view image

Paralogs for TMEM243 Gene

No data available for Paralogs for TMEM243 Gene

Variants for TMEM243 Gene

Additional dbSNP identifiers (rs#s) for TMEM243 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM243 Gene

Variant ID Type Subtype PubMed ID
dgv234n6 CNV deletion 16902084
dgv3608n106 CNV deletion 24896259
esv2141131 CNV deletion 18987734
esv2734774 CNV deletion 23290073
esv3278940 CNV deletion 24192839
esv3542039 CNV deletion 23714750
esv5173 CNV loss 18987735
esv9011 CNV loss 19470904
esv995303 CNV deletion 20482838
nsv1016761 CNV gain 25217958
nsv1076929 CNV deletion 25765185
nsv1150951 CNV deletion 26484159
nsv464622 CNV gain 19166990
nsv511977 CNV loss 21212237
nsv527889 CNV gain 19592680
nsv607725 CNV gain 21841781
nsv955981 CNV deletion 24416366

Variation tolerance for TMEM243 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM243 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM243

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM243 Gene

Disorders for TMEM243 Gene

Additional Disease Information for TMEM243

No disorders were found for TMEM243 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM243 Gene

Publications for TMEM243 Gene

  1. MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines. (PMID: 15556294) Duan Z … Seiden MV (Gene 2004) 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 54

Products for TMEM243 Gene

  • Biorbyt antibodies for TMEM243

Sources for TMEM243 Gene