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Aliases for TMEM243 Gene

Aliases for TMEM243 Gene

  • Transmembrane Protein 243 2 3 5
  • MDR1- And Mitochondrial Taxol Resistance-Associated Protein 3 4
  • Transmembrane Protein 243, Mitochondrial 2 3
  • C7orf23 3 4
  • MM-TRAG 3 4
  • MDR1 And Mitochondrial Taxol Resistance Associated Gene 2
  • MDR1 And Mitochondrial Taxol Resistance Associated 3
  • Chromosome 7 Open Reading Frame 23 2
  • Transmembrane Protein C7orf23 3
  • MMTRAG 3

External Ids for TMEM243 Gene

Previous HGNC Symbols for TMEM243 Gene

  • C7orf23

Previous GeneCards Identifiers for TMEM243 Gene

  • GC07M086826

Summaries for TMEM243 Gene

GeneCards Summary for TMEM243 Gene

TMEM243 (Transmembrane Protein 243) is a Protein Coding gene.

Additional gene information for TMEM243 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM243 Gene

Genomics for TMEM243 Gene

GeneHancer (GH) Regulatory Elements for TMEM243 Gene

Promoters and enhancers for TMEM243 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I087211 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +4.0 4035 9.5 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 TMEM243 TP53TG1 LOC101927420 ENSG00000200397 GC07M087219 GC07P087205
GH07I087151 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.4 +67.3 67294 4.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 DMTF1 PIR39826 TMEM243 TP53TG1 DBF4 ENSG00000200397 LOC101927420
GH07I087873 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 -656.3 -656301 6.4 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B CBX5 ZNF213 SLC25A40 DBF4 PIR53232 TMEM243 RUNDC3B ABCB4 ADAM22
GH07I087139 Enhancer 1 ENCODE 11.1 +79.9 79866 2 PKNOX1 SMAD1 FOXA2 ARNT ZNF766 CBX5 E2F8 ZNF592 PPARGC1A MEF2D ENSG00000200397 TMEM243 LOC101927420 PIR39826 ENSG00000261462
GH07I087187 Enhancer 0.7 dbSUPER 12.8 +24.3 24300 17.5 SOX13 PKNOX1 FOXA2 EBF1 BATF ZBTB7B TEAD3 ZNF280A ZNF121 POLR2A DMTF1 TMEM243 ENSG00000200397 TP53TG1 LOC101927420 LOC105375384 GC07P087193
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM243 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM243 Gene

Genomic Locations for TMEM243 Gene
chr7:87,196,160-87,220,587
(GRCh38/hg38)
Size:
24,428 bases
Orientation:
Minus strand
chr7:86,825,478-86,849,903
(GRCh37/hg19)

Genomic View for TMEM243 Gene

Genes around TMEM243 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM243 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM243 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM243 Gene

Proteins for TMEM243 Gene

  • Protein details for TMEM243 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU79-TM243_HUMAN
    Recommended name:
    Transmembrane protein 243
    Protein Accession:
    Q9BU79
    Secondary Accessions:
    • A4D1C6
    • B2R9I4
    • D6W5P1

    Protein attributes for TMEM243 Gene

    Size:
    118 amino acids
    Molecular mass:
    13391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM243 Gene

Post-translational modifications for TMEM243 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM243 Gene

Domains & Families for TMEM243 Gene

Gene Families for TMEM243 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM243 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM243 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU79

UniProtKB/Swiss-Prot:

TM243_HUMAN :
  • Belongs to the TMEM243 family.
Family:
  • Belongs to the TMEM243 family.
genes like me logo Genes that share domains with TMEM243: view

Function for TMEM243 Gene

Phenotypes From GWAS Catalog for TMEM243 Gene

genes like me logo Genes that share phenotypes with TMEM243: view

Animal Model Products

miRNA for TMEM243 Gene

miRTarBase miRNAs that target TMEM243

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM243 Gene

Localization for TMEM243 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM243 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM243 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM243 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM243: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM243 Gene

Pathways & Interactions for TMEM243 Gene

SuperPathways for TMEM243 Gene

No Data Available

Interacting Proteins for TMEM243 Gene

Selected Interacting proteins: Q9BU79-TM243_HUMAN for TMEM243 Gene via IID

Symbol External ID(s) Details
CREB3

Gene Ontology (GO) - Biological Process for TMEM243 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM243 Gene

Drugs & Compounds for TMEM243 Gene

No Compound Related Data Available

Transcripts for TMEM243 Gene

Unigene Clusters for TMEM243 Gene

Transmembrane protein 243, mitochondrial:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM243 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM243 Gene

GeneLoc Exon Structure for
TMEM243
ECgene alternative splicing isoforms for
TMEM243

Expression for TMEM243 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM243 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM243 Gene

This gene is overexpressed in Blymphocyte (58.4) and NK cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM243 Gene



Protein tissue co-expression partners for TMEM243 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM243 Gene:

TMEM243

SOURCE GeneReport for Unigene cluster for TMEM243 Gene:

Hs.619593

mRNA Expression by UniProt/SwissProt for TMEM243 Gene:

Q9BU79-TM243_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM243 Gene

  • Lung(3.3)
genes like me logo Genes that share expression patterns with TMEM243: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM243 Gene

Orthologs for TMEM243 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM243 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM243 34
  • 100 (a)
OneToOne
C7H7orf23 33
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia TMEM243 33 34
  • 94.07 (n)
mouse
(Mus musculus)
Mammalia Tmem243 33 16 34
  • 94.07 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM243 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM243 34
  • 91 (a)
OneToOne
C14H7orf23 33
  • 86.42 (n)
rat
(Rattus norvegicus)
Mammalia Tmem243 33
  • 90.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM243 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7ORF23 33
  • 82.44 (n)
TMEM243 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM243 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem243 33
  • 73.73 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem243b 33 34
  • 70.06 (n)
tmem243a 34
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Species where no ortholog for TMEM243 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM243 Gene

ENSEMBL:
Gene Tree for TMEM243 (if available)
TreeFam:
Gene Tree for TMEM243 (if available)

Paralogs for TMEM243 Gene

No data available for Paralogs for TMEM243 Gene

Variants for TMEM243 Gene

Sequence variations from dbSNP and Humsavar for TMEM243 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000027857 -- 87,216,529(-) A/C intron_variant
rs1000034149 -- 87,206,390(-) G/A intron_variant
rs1000078796 -- 87,215,416(-) T/A intron_variant
rs1000113605 -- 87,210,253(-) T/A intron_variant
rs1000130737 -- 87,220,109(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM243 Gene

Variant ID Type Subtype PubMed ID
nsv955981 CNV deletion 24416366
nsv607725 CNV gain 21841781
nsv527889 CNV gain 19592680
nsv511977 CNV loss 21212237
nsv464622 CNV gain 19166990
nsv1150951 CNV deletion 26484159
nsv1076929 CNV deletion 25765185
nsv1016761 CNV gain 25217958
esv995303 CNV deletion 20482838
esv9011 CNV loss 19470904
esv5173 CNV loss 18987735
esv3542039 CNV deletion 23714750
esv3278940 CNV deletion 24192839
esv2734774 CNV deletion 23290073
esv2141131 CNV deletion 18987734
dgv3608n106 CNV deletion 24896259
dgv234n6 CNV deletion 16902084

Variation tolerance for TMEM243 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM243 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM243

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM243 Gene

Disorders for TMEM243 Gene

Additional Disease Information for TMEM243

No disorders were found for TMEM243 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM243 Gene

Publications for TMEM243 Gene

  1. MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines. (PMID: 15556294) Duan Z … Seiden MV (Gene 2004) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PMID: 20351715) Liu Y … Wellcome Trust Case-Control Consortium (Molecular psychiatry 2011) 3 58

Products for TMEM243 Gene

Sources for TMEM243 Gene

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