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Aliases for TMEM239 Gene

Aliases for TMEM239 Gene

  • Transmembrane Protein 239 2 3 5

External Ids for TMEM239 Gene

Previous GeneCards Identifiers for TMEM239 Gene

  • GC20P002806

Summaries for TMEM239 Gene

GeneCards Summary for TMEM239 Gene

TMEM239 (Transmembrane Protein 239) is a Protein Coding gene.

Additional gene information for TMEM239 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM239 Gene

Genomics for TMEM239 Gene

GeneHancer (GH) Regulatory Elements for TMEM239 Gene

Promoters and enhancers for TMEM239 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I002813 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 -0.8 -835 2.1 KLF1 TAL1 KLF17 ZIC2 ZNF335 TCF12 ZNF366 NCOR1 ZBTB48 PATZ1 C20orf141 ENSG00000241690 TMEM239 CPXM1 VPS16
GH20I002816 Promoter 0.6 EPDnew 550.8 +0.5 471 0.1 PRDM1 C20orf141 TMEM239 ENSG00000241690 CPXM1 GC20P002876
GH20I002870 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +56.7 56744 4.7 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 PTPRA VPS16 PCED1A NOP56 TMEM239 C20orf141 ENSG00000241690 ITPA GC20M002886
GH20I002751 Promoter/Enhancer 1.2 Ensembl ENCODE 11.4 -63.8 -63772 0.6 CTCF KLF11 ZNF792 RB1 NRF1 SIN3A DMAP1 SREBF1 GTF3C2 ZNF335 VPS16 PTPRA PCED1A TMEM239 ENSG00000241690 C20orf141 EBF4 SNORD110 SNORD57 SNORD86
GH20I002884 Promoter 0.9 EPDnew 10.3 +68.9 68901 0.1 ZNF140 JUNB BATF ATF2 ZNF316 TARDBP IKZF1 NBN MLLT1 RUNX3 PTPRA VPS16 NOP56 PCED1A ZNF343 ENSG00000241690 TMEM239 C20orf141 GC20M002886
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM239 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM239 Gene

Genomic Locations for TMEM239 Gene
chr20:2,815,874-2,820,284
(GRCh38/hg38)
Size:
4,411 bases
Orientation:
Plus strand
chr20:2,795,614-2,800,930
(GRCh37/hg19)

Genomic View for TMEM239 Gene

Genes around TMEM239 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM239 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM239 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM239 Gene

Proteins for TMEM239 Gene

  • Protein details for TMEM239 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW34-TM239_HUMAN
    Recommended name:
    Transmembrane protein 239
    Protein Accession:
    Q8WW34
    Secondary Accessions:
    • Q5JY54
    • Q6ZU23

    Protein attributes for TMEM239 Gene

    Size:
    195 amino acids
    Molecular mass:
    21842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21178.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM239 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM239 Gene

Post-translational modifications for TMEM239 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM239 Gene

No data available for DME Specific Peptides for TMEM239 Gene

Domains & Families for TMEM239 Gene

Gene Families for TMEM239 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM239 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM239: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM239 Gene

Function for TMEM239 Gene

Phenotypes From GWAS Catalog for TMEM239 Gene

Gene Ontology (GO) - Molecular Function for TMEM239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM239: view

Phenotypes for TMEM239 Gene

GenomeRNAi human phenotypes for TMEM239:
genes like me logo Genes that share phenotypes with TMEM239: view

miRNA for TMEM239 Gene

miRTarBase miRNAs that target TMEM239

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM239 Gene

Localization for TMEM239 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM239 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM239 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM239: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM239 Gene

Pathways & Interactions for TMEM239 Gene

SuperPathways for TMEM239 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM239 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM239 Gene

Drugs & Compounds for TMEM239 Gene

No Compound Related Data Available

Transcripts for TMEM239 Gene

mRNA/cDNA for TMEM239 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM239 Gene

Transmembrane protein 239:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM239 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for TMEM239 Gene

GeneLoc Exon Structure for
TMEM239
ECgene alternative splicing isoforms for
TMEM239

Expression for TMEM239 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM239 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM239 Gene:

TMEM239

SOURCE GeneReport for Unigene cluster for TMEM239 Gene:

Hs.664180
genes like me logo Genes that share expression patterns with TMEM239: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM239 Gene

Orthologs for TMEM239 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM239 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM239 33 34
  • 98.71 (n)
rat
(Rattus norvegicus)
Mammalia Tmem239 33
  • 87.64 (n)
dog
(Canis familiaris)
Mammalia TMEM239 33 34
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Tmem239 33 16 34
  • 86.09 (n)
cow
(Bos Taurus)
Mammalia TMEM239 33 34
  • 85.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM239 34
  • 62 (a)
OneToOne
Species where no ortholog for TMEM239 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM239 Gene

ENSEMBL:
Gene Tree for TMEM239 (if available)
TreeFam:
Gene Tree for TMEM239 (if available)

Paralogs for TMEM239 Gene

(1) SIMAP similar genes for TMEM239 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM239: view

No data available for Paralogs for TMEM239 Gene

Variants for TMEM239 Gene

Sequence variations from dbSNP and Humsavar for TMEM239 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs386352285 uncertain-significance, not provided 2,815,542(+) G/A/T upstream_transcript_variant
rs1000129781 -- 2,820,214(+) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001669108 -- 2,816,656(+) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1003213980 -- 2,819,405(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1003233463 -- 2,813,958(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM239 Gene

Variant ID Type Subtype PubMed ID
esv2762056 CNV gain 21179565
esv3645020 CNV gain 21293372
nsv1057464 CNV gain 25217958
nsv510780 CNV deletion 20534489
nsv518364 CNV loss 19592680
nsv522009 CNV gain 19592680
nsv833895 CNV loss 17160897

Variation tolerance for TMEM239 Gene

Gene Damage Index Score: 2.21; 39.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM239 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM239

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM239 Gene

Disorders for TMEM239 Gene

Additional Disease Information for TMEM239

No disorders were found for TMEM239 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM239 Gene

Publications for TMEM239 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  2. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E … McIntosh AM (Psychiatry research 2013) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TMEM239 Gene

Sources for TMEM239 Gene

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