Aliases for TMEM238 Gene

Aliases for TMEM238 Gene

  • Transmembrane Protein 238 2 3 4 5
  • TMEM238 5

External Ids for TMEM238 Gene

Previous GeneCards Identifiers for TMEM238 Gene

  • GC19M055891

Summaries for TMEM238 Gene

GeneCards Summary for TMEM238 Gene

TMEM238 (Transmembrane Protein 238) is a Protein Coding gene. Diseases associated with TMEM238 include Adult Syndrome and Chromosome 1P36 Deletion Syndrome.

Additional gene information for TMEM238 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM238 Gene

Genomics for TMEM238 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM238 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM238 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM238

Genomic Locations for TMEM238 Gene

Genomic Locations for TMEM238 Gene
chr19:55,379,244-55,384,292
(GRCh38/hg38)
Size:
5,049 bases
Orientation:
Minus strand
chr19:55,890,612-55,895,966
(GRCh37/hg19)
Size:
5,355 bases
Orientation:
Minus strand

Genomic View for TMEM238 Gene

Genes around TMEM238 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM238 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM238 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM238 Gene

Proteins for TMEM238 Gene

  • Protein details for TMEM238 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JI98-TM238_HUMAN
    Recommended name:
    Transmembrane protein 238
    Protein Accession:
    C9JI98

    Protein attributes for TMEM238 Gene

    Size:
    176 amino acids
    Molecular mass:
    18040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM238 Gene

Post-translational modifications for TMEM238 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM238 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM238 Gene

Domains & Families for TMEM238 Gene

Gene Families for TMEM238 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM238 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM238: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM238 Gene

Function for TMEM238 Gene

Phenotypes From GWAS Catalog for TMEM238 Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM238

CRISPR Products

miRNA for TMEM238 Gene

miRTarBase miRNAs that target TMEM238

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM238

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM238 Gene

Localization for TMEM238 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM238 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM238 gene
Compartment Confidence
plasma membrane 2
extracellular 0
mitochondrion 0

Gene Ontology (GO) - Cellular Components for TMEM238 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM238: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM238 Gene

Pathways & Interactions for TMEM238 Gene

PathCards logo

SuperPathways for TMEM238 Gene

No Data Available

Interacting Proteins for TMEM238 Gene

Gene Ontology (GO) - Biological Process for TMEM238 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM238 Gene

Drugs & Compounds for TMEM238 Gene

No Compound Related Data Available

Transcripts for TMEM238 Gene

mRNA/cDNA for TMEM238 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM238

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM238 Gene

No ASD Table

Relevant External Links for TMEM238 Gene

GeneLoc Exon Structure for
TMEM238

Expression for TMEM238 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM238 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM238 Gene

This gene is overexpressed in Colon - Transverse (x6.7) and Pancreas (x5.0).

Protein differential expression in normal tissues from HIPED for TMEM238 Gene

This gene is overexpressed in Lung (58.2) and Fetal gut (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM238 Gene



Protein tissue co-expression partners for TMEM238 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM238

SOURCE GeneReport for Unigene cluster for TMEM238 Gene:

Hs.534672
genes like me logo Genes that share expression patterns with TMEM238: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM238 Gene

Orthologs for TMEM238 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM238 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM238 30 31
  • 98.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM238 30
  • 92.07 (n)
Cow
(Bos Taurus)
Mammalia TMEM238 30
  • 89.96 (n)
Mouse
(Mus musculus)
Mammalia Tmem238 30 17 31
  • 86.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem238 30
  • 84.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM238 31
  • 13 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem238 30
  • 61.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem238 31
  • 44 (a)
OneToOne
Species where no ortholog for TMEM238 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM238 Gene

ENSEMBL:
Gene Tree for TMEM238 (if available)
TreeFam:
Gene Tree for TMEM238 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM238: view image

Paralogs for TMEM238 Gene

No data available for Paralogs for TMEM238 Gene

Variants for TMEM238 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM238 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769465 Benign: not provided 55,384,220(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM238 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM238 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM238 Gene

Gene Damage Index Score: 1.02; 21.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM238 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM238

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM238 Gene

Disorders for TMEM238 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM238 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adult syndrome
  • acro-dermato-ungual-lacrimal-tooth syndrome
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMEM238: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM238 Gene

Publications for TMEM238 Gene

  1. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMEM238 Gene

Sources for TMEM238 Gene