Aliases for TMEM236 Gene

Aliases for TMEM236 Gene

  • Transmembrane Protein 236 2 3 4 5
  • Family With Sequence Similarity 23, Member A 2 3
  • Family With Sequence Similarity 23, Member B 2 3
  • FAM23A 3 4
  • FAM23B 3 4
  • BA162I21.2 3
  • BA16O1.2 3

External Ids for TMEM236 Gene

Previous HGNC Symbols for TMEM236 Gene

  • FAM23B
  • FAM23A

Previous GeneCards Identifiers for TMEM236 Gene

  • GC10P017796

Summaries for TMEM236 Gene

GeneCards Summary for TMEM236 Gene

TMEM236 (Transmembrane Protein 236) is a Protein Coding gene.

Additional gene information for TMEM236 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM236 Gene

Genomics for TMEM236 Gene

GeneHancer (GH) Regulatory Elements for TMEM236 Gene

Promoters and enhancers for TMEM236 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J017423 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 10.3 -325.5 -325493 6.2 BCLAF1 PHB2 ZBTB5 ZIC2 ZBTB11 AFF1 TARDBP REST DNMT1 HES1 lnc-VIM-2 ST8SIA6 TMEM236 ST8SIA6-AS1 STAM TRDMT1 ENSG00000251803
GH10J017616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.8 -135.1 -135101 3 NRF1 POLR2G NCOR1 TEAD4 ZIC2 POLR2A ZBTB26 HES1 ZBTB25 ZBTB7A HACD1 TMEM236 VIM lnc-ST8SIA6-4
GH10J017607 Enhancer 0.9 Ensembl ENCODE 6.1 -143.1 -143100 3.8 CTCF REST RAD21 TRIM22 SMC3 ARNT ZNF511 ZGPAT PKNOX1 ZNF654 HACD1 TMEM236 lnc-ST8SIA6-4
GH10J017578 Enhancer 1 Ensembl ENCODE 4.3 -173.0 -173000 2.4 PHB2 TARDBP HES1 HDAC3 NR2F2 NCOR1 TRIM25 ZNF316 NFIC ARNT PRPF38AP2 lnc-STAM-2 HACD1 ST8SIA6 TMEM236 piR-56133-023
GH10J017802 Enhancer 0.2 Ensembl 6.9 +50.9 50900 1.4 TMEM236 piR-38661-001 HSALNG0076476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM236 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM236

Genomic Locations for TMEM236 Gene

Genomic Locations for TMEM236 Gene
chr10:17,752,201-17,800,887
(GRCh38/hg38)
Size:
48,687 bases
Orientation:
Plus strand
chr10:17,794,251-17,842,867
(GRCh37/hg19)
Size:
48,617 bases
Orientation:
Plus strand

Genomic View for TMEM236 Gene

Genes around TMEM236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM236 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM236 Gene

Proteins for TMEM236 Gene

  • Protein details for TMEM236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0B7-TM236_HUMAN
    Recommended name:
    Transmembrane protein 236
    Protein Accession:
    Q5W0B7
    Secondary Accessions:
    • B2RXH7

    Protein attributes for TMEM236 Gene

    Size:
    351 amino acids
    Molecular mass:
    39663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM236 Gene

Post-translational modifications for TMEM236 Gene

  • Glycosylation at Asn193
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM236 Gene

No data available for DME Specific Peptides for TMEM236 Gene

Domains & Families for TMEM236 Gene

Gene Families for TMEM236 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM236 Gene

Suggested Antigen Peptide Sequences for TMEM236 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 236 (TM236_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5W0B7

UniProtKB/Swiss-Prot:

TM236_HUMAN :
  • Belongs to the TMEM236 family.
Family:
  • Belongs to the TMEM236 family.
genes like me logo Genes that share domains with TMEM236: view

Function for TMEM236 Gene

Phenotypes From GWAS Catalog for TMEM236 Gene

genes like me logo Genes that share phenotypes with TMEM236: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM236 Gene

Localization for TMEM236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM236 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM236: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM236 Gene

Pathways & Interactions for TMEM236 Gene

PathCards logo

SuperPathways for TMEM236 Gene

No Data Available

Interacting Proteins for TMEM236 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000366715 Q5W0B7-TM236_HUMAN for TMEM236 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TMEM236 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM236 Gene

Drugs & Compounds for TMEM236 Gene

No Compound Related Data Available

Transcripts for TMEM236 Gene

mRNA/cDNA for TMEM236 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM236 Gene

No ASD Table

Relevant External Links for TMEM236 Gene

GeneLoc Exon Structure for
TMEM236

Expression for TMEM236 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM236 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM236 Gene

This gene is overexpressed in Colon - Transverse (x19.1) and Small Intestine - Terminal Ileum (x13.3).

Protein differential expression in normal tissues from HIPED for TMEM236 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM236 Gene



Protein tissue co-expression partners for TMEM236 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM236

SOURCE GeneReport for Unigene cluster for TMEM236 Gene:

Hs.564139
genes like me logo Genes that share expression patterns with TMEM236: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM236 Gene

Orthologs for TMEM236 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM236 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM236 30
  • 99.43 (n)
-- 31
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM236 30
  • 78.57 (n)
-- 31
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem236 30
  • 78.32 (n)
cow
(Bos Taurus)
Mammalia TMEM236 30
  • 78.13 (n)
-- 31
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem236 17 31 30
  • 77.52 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32m20.1 31 30
  • 49.95 (n)
ManyToMany
CR376779.2 31
  • 40 (a)
ManyToMany
Species where no ortholog for TMEM236 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM236 Gene

ENSEMBL:
Gene Tree for TMEM236 (if available)
TreeFam:
Gene Tree for TMEM236 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM236: view image

Paralogs for TMEM236 Gene

No data available for Paralogs for TMEM236 Gene

Variants for TMEM236 Gene

Additional dbSNP identifiers (rs#s) for TMEM236 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM236 Gene

Variant ID Type Subtype PubMed ID
esv21990 CNV loss 19812545

Variation tolerance for TMEM236 Gene

Gene Damage Index Score: 5.39; 71.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM236 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM236 Gene

Disorders for TMEM236 Gene

Additional Disease Information for TMEM236

No disorders were found for TMEM236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM236 Gene

Publications for TMEM236 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54

Products for TMEM236 Gene

Sources for TMEM236 Gene