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Aliases for TMEM235 Gene
Aliases for TMEM235 Gene
External Ids for TMEM235 Gene
- HGNC: 27563
- Entrez Gene: 283999
- Ensembl: ENSG00000204278
- UniProtKB: A6NFC5
Previous GeneCards Identifiers for TMEM235 Gene
- GC17P076228
Summaries for TMEM235 Gene
GeneCards Summary for TMEM235 Gene
TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. Diseases associated with TMEM235 include Renal Glucosuria. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.
Additional gene information for TMEM235 Gene
- HGNC(27563)
- Entrez Gene(283999)
- Ensembl(ENSG00000204278)
- UniProtKB(A6NFC5)
- Open Targets Platform(ENSG00000204278)
- Search for TMEM235 at DataMed
- Search for TMEM235 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM235 Gene
Genomics for TMEM235 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMEM235 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J078235 | Promoter/Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 600.7 | +0.6 | 608 | 0.6 | EZH2 YY1 ZBTB33 | TMEM235 ENSG00000283914 SOCS3 | |
| GH17J078242 | Promoter/Enhancer | 0.9 | Ensembl dbSUPER | 600.7 | +1.6 | 1608 | 0.2 | MNT EGR1 HDGF ZFHX2 ZNF18 TARDBP BHLHE40 EGR2 EZH2 | TMEM235 ENSG00000283914 SOCS3 | |
| GH17J078231 | Promoter/Enhancer | 0.6 | EPDnew dbSUPER | 600.7 | 0.0 | -19 | 0.1 | EZH2 | TMEM235 lnc-TK1-2 BIRC5 | |
| GH17J078234 | Enhancer | 0.5 | dbSUPER | 600.7 | +1.3 | 1311 | 0.2 | EZH2 HDGF ZNF18 ZBTB33 TARDBP | TMEM235 BIRC5 ENSG00000283914 SOCS3 | |
| GH17J078230 | Enhancer | 0.5 | dbSUPER | 600.7 | -0.3 | -291 | 0.1 | RUNX3 IKZF1 BHLHE40 L3MBTL2 EZH2 | TMEM235 lnc-TK1-2 BIRC5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMEM235 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM235
Genomic Locations for TMEM235 Gene
Genomic Locations for TMEM235 Gene
- chr17:78,231,293-78,242,849
- (GRCh38/hg38)
- Size:
- 11,557 bases
- Orientation:
- Plus strand
- chr17:76,227,391-76,237,068
- (GRCh37/hg19)
- Size:
- 9,678 bases
- Orientation:
- Plus strand
Genomic View for TMEM235 Gene
Genes around TMEM235 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
TMEM235 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM235 Gene
Proteins for TMEM235 Gene
-
Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NFC5-TM235_HUMAN
- Recommended name:
- Transmembrane protein 235
- Protein Accession:
- A6NFC5
- C9JRE6
Protein attributes for TMEM235 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 23360 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TMEM235 Gene
Post-translational modifications for TMEM235 Gene
- N-glycosylated.
-
Glycosylation at Asn41
- NX_A6NFC5 (NX_A6NFC5-1)
Other Protein References for TMEM235 Gene
Antibody Products
- Novus Biologicals Antibodies for TMEM235
- Invitrogen Antibodies for TMEM235 (AFLGC-TMEM235)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM235
- Origene Custom Protein Services for TMEM235
- Novus Biologicals proteins for TMEM235
No data available for DME Specific Peptides for TMEM235 Gene
Domains & Families for TMEM235 Gene
Gene Families for TMEM235 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TMEM235 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM235 Gene
- GenScript: Design optimal peptide antigens:
-
- Transmembrane protein 235 (TM235_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A6NFC5- Family:
-
- Belongs to the PMP-22/EMP/MP20 family.
Function for TMEM235 Gene
Phenotypes From GWAS Catalog for TMEM235 Gene
Phenotypes for TMEM235 Gene
- GenomeRNAi human phenotypes for TMEM235:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM235 - Select products 50% OFF >
- * TMEM235 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM235
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM235
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM235
- Browse OriGene Inhibitory RNA Products For TMEM235
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM235
Clone Products
- Applied Biological Materials (abm): Clones for TMEM235 - Select products 50% OFF >
- * TMEM235 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM235
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM235
Cell Line Products
-
Horizon Cell Lines for TMEM235
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM235 Gene
Localization for TMEM235 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene
- Membrane. Multi-pass membrane protein. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| endoplasmic reticulum | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM235 Gene
Transcripts for TMEM235 Gene
mRNA/cDNA for TMEM235 Gene
- 4 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374946 2409 nts (view in UCSC)
- ENST00000421688 2490 nts (view in UCSC)
- ENST00000550981 1786 nts (view in UCSC)
- ENST00000551068 1187 nts (view in UCSC)
- ENST00000586400 2272 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM235 - Select products 50% OFF >
- * TMEM235 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM235
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM235
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM235
- Browse OriGene Inhibitory RNA Products For TMEM235
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM235
Clone Products
- Applied Biological Materials (abm): Clones for TMEM235 - Select products 50% OFF >
- * TMEM235 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM235
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM235
Relevant External Links for TMEM235 Gene
- GeneLoc Exon Structure for
- TMEM235
Expression for TMEM235 Gene
mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.8), Brain - Hippocampus (x6.4), Brain - Putamen (basal ganglia) (x6.0), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hypothalamus (x4.6).
This gene is overexpressed in Frontal cortex (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM235 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM235
SOURCE GeneReport for Unigene cluster for TMEM235 Gene:
Hs.632228Primer Products
-
OriGene qPCR primer pairs for TMEM235
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM235 Gene
Orthologs for TMEM235 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMEM235 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TMEM235 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TMEM235 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tmem235 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tmem235 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | TMEM235 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch73-369d14.2 30 |
|
||
| CABZ01013481.2 31 |
|
OneToMany | |||
| TMEM235 (1 of 2) 31 |
|
OneToMany |
- Species where no ortholog for TMEM235 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TMEM235 Gene
- ENSEMBL:
- Gene Tree for TMEM235 (if available)
- TreeFam:
- Gene Tree for TMEM235 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM235: view image
Paralogs for TMEM235 Gene
Variants for TMEM235 Gene
Gene Damage Index Score:
6.46;
77.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM235 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM235
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM235 Gene
Disorders for TMEM235 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal glucosuria |
|
|
Search TMEM235 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMEM235
No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM235 Gene
Publications for TMEM235 Gene
- The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher GJ … Manson FD (FEBS letters 2011) 2 3 4
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for TMEM235 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM235
- Origene Custom Protein Services for TMEM235
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM235
- Browse OriGene Inhibitory RNA Products For TMEM235
- OriGene qPCR primer pairs for TMEM235
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMEM235
- Sino Biological Human cDNA Clone for TMEM235
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TMEM235
- Novus Biologicals proteins for TMEM235
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for TMEM235 (AFLGC-TMEM235)
- VectorBuilder Custom and pre-made DNA vectors for TMEM235 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMEM235 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMEM235 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMEM235 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMEM235
- Horizon Cell Lines for TMEM235
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM235
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM235
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMEM235
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM235
Sources for TMEM235 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB