TMEM235 Gene (Protein Coding)

Transmembrane Protein 235

GC17P078231
GIFtS:
28
See more...

Aliases for TMEM235 Gene

Aliases for TMEM235 Gene

  • Transmembrane Protein 235 2 3 4 5
  • Transmembrane Protein ENSP00000364084 3
  • TMEM235 5
  • ARGM1 3

External Ids for TMEM235 Gene

Previous GeneCards Identifiers for TMEM235 Gene

  • GC17P076228

Summaries for TMEM235 Gene

GeneCards Summary for TMEM235 Gene

TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. Diseases associated with TMEM235 include Renal Glucosuria. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.

Additional gene information for TMEM235 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM235 Gene

Genomics for TMEM235 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TMEM235 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J078242 Promoter/Enhancer 0.9 Ensembl dbSUPER 250.7 +1.6 1608 0.2 BHLHE40 HDGF ZNF18 EGR2 TARDBP MNT ZFHX2 EGR1 HSALNG0119020 TMEM235 HSALNG0119021 SOCS3
GH17J078245 Promoter/Enhancer 0.7 Ensembl dbSUPER 250.7 +0.5 508 0.4 YY1 EZH2 HSALNG0119020 TMEM235 SOCS3
GH17J078231 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 0.0 -19 0.1 EZH2 HSALNG0119020 TMEM235 lnc-TK1-2 BIRC5
GH17J078235 Enhancer 0.6 ENCODE dbSUPER 250.7 +0.8 832 0.1 YY1 ZBTB33 EZH2 HSALNG0119020 TMEM235 SOCS3
GH17J078234 Enhancer 0.5 dbSUPER 250.7 +1.3 1311 0.2 ZBTB33 HDGF ZNF18 EZH2 TARDBP HSALNG0119020 TMEM235 BIRC5 HSALNG0119021 SOCS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM235 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM235

Genomic Locations for TMEM235 Gene

Latest Assembly
chr17:78,231,293-78,242,849
(GRCh38/hg38)
Size:
11,557 bases
Orientation:
Plus strand

Previous Assembly
chr17:76,227,374-76,237,068
(GRCh37/hg19 by Entrez Gene)
Size:
9,695 bases
Orientation:
Plus strand

chr17:76,227,391-76,237,068
(GRCh37/hg19 by Ensembl)
Size:
9,678 bases
Orientation:
Plus strand

Genomic View for TMEM235 Gene

Genes around TMEM235 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM235 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM235 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TMEM235 Gene

Proteins for TMEM235 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC5-TM235_HUMAN
    Recommended name:
    Transmembrane protein 235
    Protein Accession:
    A6NFC5
    Secondary Accessions:
    • C9JRE6

    Protein attributes for TMEM235 Gene

    Size:
    223 amino acids
    Molecular mass:
    23360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM235 Gene

Protein Expression for TMEM235 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TMEM235 Gene

Other Protein References for TMEM235 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM235 Gene

Domains & Families for TMEM235 Gene

Gene Families for TMEM235 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM235 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM235 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 235 (TM235_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NFC5

UniProtKB/Swiss-Prot:

TM235_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with TMEM235: view

Function for TMEM235 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for TMEM235 Gene

Phenotypes for TMEM235 Gene

GenomeRNAi human phenotypes for TMEM235:
genes like me logo Genes that share phenotypes with TMEM235: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM235

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM235 Gene

Localization for TMEM235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene

Membrane. Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM235 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
nucleus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with TMEM235: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM235 Gene

Pathways & Interactions for TMEM235 Gene

PathCards logo

SuperPathways for TMEM235 Gene

No Data Available

Interacting Proteins for TMEM235 Gene

Gene Ontology (GO) - Biological Process for TMEM235 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM235 Gene

Drugs & Compounds for TMEM235 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for TMEM235 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for TMEM235 Gene

6 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM235

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM235 Gene

No ASD Table

Relevant External Links for TMEM235 Gene

GeneLoc Exon Structure for
TMEM235

Expression for TMEM235 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM235 Gene

mRNA expression in normal human tissues for TMEM235 Gene
mRNA expression by GTEx for TMEM235 GenemRNA expression by BioGPS for TMEM235 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.8), Brain - Hippocampus (x6.4), Brain - Putamen (basal ganglia) (x6.0), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM235 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM235 Gene



Protein tissue co-expression partners for TMEM235 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM235

SOURCE GeneReport for Unigene cluster for TMEM235 Gene:

Hs.632228
genes like me logo Genes that share expression patterns with TMEM235: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM235 Gene

Orthologs for TMEM235 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM235 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TMEM235 30
  • 98.64 (n)
Cow
(Bos Taurus)
 Mammalia TMEM235 30 31
  • 86.42 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TMEM235 30 31
  • 83.52 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tmem235 30 17 31
  • 80.15 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tmem235 30
  • 78.81 (n)
Lizard
(Anolis carolinensis)
 Reptilia TMEM235 31
  • 52 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii si:ch73-369d14.2 30
  • 55.42 (n)
CABZ01013481.2 31
  • 46 (a)
 OneToMany
TMEM235 (1 of 2) 31
  • 41 (a)
 OneToMany
Species where no ortholog for TMEM235 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM235 Gene

ENSEMBL:
Gene Tree for TMEM235 (if available)
TreeFam:
Gene Tree for TMEM235 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM235: view image

Paralogs for TMEM235 Gene

Paralogs for TMEM235 Gene

(1) SIMAP similar genes for TMEM235 Gene using alignment to 2 proteins:

  • TM235_HUMAN
  • K7EMB0_HUMAN
genes like me logo Genes that share paralogs with TMEM235: view

Variants for TMEM235 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM235 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM235 Gene

Variant ID Type Subtype PubMed ID
nsv1066985 CNV gain 25217958
nsv470608 CNV loss 18288195
nsv524306 CNV gain 19592680
nsv952373 CNV deletion 24416366

Variation tolerance for TMEM235 Gene

Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM235 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM235

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM235 Gene

Disorders for TMEM235 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM235 Gene - From: COP

Disorder Aliases PubMed IDs
renal glucosuria
  • glys
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM235

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMEM235: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM235 Gene

Publications for TMEM235 Gene

  1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher GJ … Manson FD (FEBS letters 2011) 2 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

ExternalLinks

View latest publications for TMEM235 gene in Mastermind

Products for TMEM235 Gene

Sources for TMEM235 Gene