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Aliases for TMEM235 Gene

Aliases for TMEM235 Gene

  • Transmembrane Protein 235 2 3 5
  • Transmembrane Protein ENSP00000364084 3
  • ARGM1 3

External Ids for TMEM235 Gene

Previous GeneCards Identifiers for TMEM235 Gene

  • GC17P076228

Summaries for TMEM235 Gene

GeneCards Summary for TMEM235 Gene

TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.

Additional gene information for TMEM235 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM235 Gene

Genomics for TMEM235 Gene

GeneHancer (GH) Regulatory Elements for TMEM235 Gene

Promoters and enhancers for TMEM235 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I078232 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 +0.3 302 0.1 EZH2 TMEM235 LOC105371910
GH17I078231 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 0.0 -36 0.1 EZH2 TMEM235 GC17M078223
GH17I078237 Enhancer 0.6 ENCODE dbSUPER 550.8 +0.8 815 0.1 CTBP2 ZBTB33 EZH2 TMEM235 LOC105371910
GH17I078234 Enhancer 0.5 dbSUPER 550.8 +1.1 1057 0.2 SUZ12 CTBP2 ZBTB33 EZH2 TMEM235 LOC105371910
GH17I078235 Enhancer 0.5 dbSUPER 550.8 +1.3 1294 0.2 HDGF SUZ12 TARDBP CTBP2 ZBTB33 ZNF18 EZH2 TMEM235 BIRC5 LOC105371910
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM235 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM235 Gene

Genomic Locations for TMEM235 Gene
chr17:78,231,310-78,240,987
(GRCh38/hg38)
Size:
9,678 bases
Orientation:
Plus strand
chr17:76,227,391-76,237,068
(GRCh37/hg19)

Genomic View for TMEM235 Gene

Genes around TMEM235 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM235 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM235 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM235 Gene

Proteins for TMEM235 Gene

  • Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC5-TM235_HUMAN
    Recommended name:
    Transmembrane protein 235
    Protein Accession:
    A6NFC5
    Secondary Accessions:
    • C9JRE6

    Protein attributes for TMEM235 Gene

    Size:
    223 amino acids
    Molecular mass:
    23360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM235 Gene

Post-translational modifications for TMEM235 Gene

No data available for DME Specific Peptides for TMEM235 Gene

Domains & Families for TMEM235 Gene

Gene Families for TMEM235 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM235 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM235 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFC5

UniProtKB/Swiss-Prot:

TM235_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with TMEM235: view

Function for TMEM235 Gene

Phenotypes From GWAS Catalog for TMEM235 Gene

Phenotypes for TMEM235 Gene

GenomeRNAi human phenotypes for TMEM235:
genes like me logo Genes that share phenotypes with TMEM235: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM235 Gene

Localization for TMEM235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM235 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with TMEM235: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM235 Gene

Pathways & Interactions for TMEM235 Gene

SuperPathways for TMEM235 Gene

No Data Available

Interacting Proteins for TMEM235 Gene

Gene Ontology (GO) - Biological Process for TMEM235 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM235 Gene

Drugs & Compounds for TMEM235 Gene

No Compound Related Data Available

Transcripts for TMEM235 Gene

mRNA/cDNA for TMEM235 Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM235 Gene

Transmembrane protein 235:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM235 Gene

No ASD Table

Relevant External Links for TMEM235 Gene

GeneLoc Exon Structure for
TMEM235
ECgene alternative splicing isoforms for
TMEM235

Expression for TMEM235 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM235 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.8), Brain - Hippocampus (x6.4), Brain - Putamen (basal ganglia) (x6.0), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM235 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM235 Gene



Protein tissue co-expression partners for TMEM235 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM235 Gene:

TMEM235

SOURCE GeneReport for Unigene cluster for TMEM235 Gene:

Hs.632228
genes like me logo Genes that share expression patterns with TMEM235: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM235 Gene

Orthologs for TMEM235 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM235 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM235 33
  • 98.64 (n)
cow
(Bos Taurus)
Mammalia TMEM235 33 34
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia TMEM235 33 34
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Tmem235 33 16 34
  • 80.15 (n)
rat
(Rattus norvegicus)
Mammalia Tmem235 33
  • 78.81 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM235 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-369d14.2 33
  • 55.42 (n)
CABZ01013481.2 34
  • 46 (a)
OneToMany
TMEM235 (1 of 2) 34
  • 41 (a)
OneToMany
Species where no ortholog for TMEM235 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM235 Gene

ENSEMBL:
Gene Tree for TMEM235 (if available)
TreeFam:
Gene Tree for TMEM235 (if available)

Paralogs for TMEM235 Gene

Paralogs for TMEM235 Gene

(1) SIMAP similar genes for TMEM235 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM235: view

Variants for TMEM235 Gene

Sequence variations from dbSNP and Humsavar for TMEM235 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000032463 -- 78,239,498(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000400713 -- 78,230,252(+) G/A upstream_transcript_variant
rs1000452635 -- 78,243,210(+) C/T downstream_transcript_variant
rs1000571248 -- 78,233,446(+) G/A intron_variant
rs1000932439 -- 78,231,736(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM235 Gene

Variant ID Type Subtype PubMed ID
nsv1066985 CNV gain 25217958
nsv470608 CNV loss 18288195
nsv524306 CNV gain 19592680
nsv952373 CNV deletion 24416366

Variation tolerance for TMEM235 Gene

Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM235 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM235

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM235 Gene

Disorders for TMEM235 Gene

Additional Disease Information for TMEM235

No disorders were found for TMEM235 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM235 Gene

Publications for TMEM235 Gene

  1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher GJ … Manson FD (FEBS letters 2011) 2 3 4 58
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM235 Gene

Sources for TMEM235 Gene

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