Aliases for TMEM234 Gene

Aliases for TMEM234 Gene

  • Transmembrane Protein 234 2 3 4 5
  • C1orf91 3 4
  • Chromosome 1 Open Reading Frame 91 2
  • RP4-622L5 3
  • DJ622L5.7 3
  • AASL548 3
  • PRO1105 3

External Ids for TMEM234 Gene

Previous HGNC Symbols for TMEM234 Gene

  • C1orf91

Previous GeneCards Identifiers for TMEM234 Gene

  • GC01M032681

Summaries for TMEM234 Gene

GeneCards Summary for TMEM234 Gene

TMEM234 (Transmembrane Protein 234) is a Protein Coding gene.

Additional gene information for TMEM234 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM234 Gene

Genomics for TMEM234 Gene

GeneHancer (GH) Regulatory Elements for TMEM234 Gene

Promoters and enhancers for TMEM234 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM234 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM234 Gene

Genomic Locations for TMEM234 Gene
chr1:32,204,806-32,222,359
(GRCh38/hg38)
Size:
17,554 bases
Orientation:
Minus strand
chr1:32,680,073-32,687,972
(GRCh37/hg19)
Size:
7,900 bases
Orientation:
Minus strand

Genomic View for TMEM234 Gene

Genes around TMEM234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM234 Gene

Proteins for TMEM234 Gene

  • Protein details for TMEM234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY98-TM234_HUMAN
    Recommended name:
    Transmembrane protein 234
    Protein Accession:
    Q8WY98
    Secondary Accessions:
    • B2R535
    • D3DPP7
    • Q6UWY9
    • Q8N2H6
    • Q9BSR2
    • Q9NU76

    Protein attributes for TMEM234 Gene

    Size:
    164 amino acids
    Molecular mass:
    17601 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=BAC11504.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM234 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM234 Gene

Post-translational modifications for TMEM234 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM234 Gene

Domains & Families for TMEM234 Gene

Gene Families for TMEM234 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM234 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM234 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57725 (B4DHR3_HUMAN)
  • Transmembrane protein 234 (TM234_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WY98

UniProtKB/Swiss-Prot:

TM234_HUMAN :
  • Belongs to the TMEM234 family.
Family:
  • Belongs to the TMEM234 family.
genes like me logo Genes that share domains with TMEM234: view

Function for TMEM234 Gene

Phenotypes From GWAS Catalog for TMEM234 Gene

Gene Ontology (GO) - Molecular Function for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM234: view
genes like me logo Genes that share phenotypes with TMEM234: view

Animal Models for TMEM234 Gene

MGI Knock Outs for TMEM234:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM234

CRISPR Products

miRNA for TMEM234 Gene

miRTarBase miRNAs that target TMEM234

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM234

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM234 Gene

Localization for TMEM234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM234 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM234 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM234: view

Pathways & Interactions for TMEM234 Gene

PathCards logo

SuperPathways for TMEM234 Gene

No Data Available

Interacting Proteins for TMEM234 Gene

;

Gene Ontology (GO) - Biological Process for TMEM234 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM234 Gene

Drugs & Compounds for TMEM234 Gene

No Compound Related Data Available

Transcripts for TMEM234 Gene

mRNA/cDNA for TMEM234 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM234

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM234 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - -

Relevant External Links for TMEM234 Gene

GeneLoc Exon Structure for
TMEM234

Expression for TMEM234 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM234 Gene

Protein differential expression in normal tissues from HIPED for TMEM234 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM234 Gene



Protein tissue co-expression partners for TMEM234 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM234

SOURCE GeneReport for Unigene cluster for TMEM234 Gene:

Hs.272299

Evidence on tissue expression from TISSUES for TMEM234 Gene

  • Thyroid gland(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM234: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM234 Gene

Orthologs for TMEM234 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM234 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM234 31 30
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM234 31 30
  • 91.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM234 31 30
  • 90.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem234 17 31 30
  • 85.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM234 31
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM234 31
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM234 30
  • 65.35 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM234 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem234 30
  • 59.71 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem234 31 30
  • 59.32 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12929 31 30
  • 46.5 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta U546_ANOGA 30
  • 43.83 (n)
Species where no ortholog for TMEM234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM234 Gene

ENSEMBL:
Gene Tree for TMEM234 (if available)
TreeFam:
Gene Tree for TMEM234 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM234: view image

Paralogs for TMEM234 Gene

No data available for Paralogs for TMEM234 Gene

Variants for TMEM234 Gene

Additional dbSNP identifiers (rs#s) for TMEM234 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM234 Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for TMEM234 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM234 Gene

Disorders for TMEM234 Gene

Additional Disease Information for TMEM234

No disorders were found for TMEM234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM234 Gene

Publications for TMEM234 Gene

  1. Knockdown of Tmem234 in zebrafish results in proteinuria. (PMID: 26377798) Rodriguez PQ … Patrakka J (American journal of physiology. Renal physiology 2015) 2 3 54
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 54

Products for TMEM234 Gene

Sources for TMEM234 Gene