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Aliases for TMEM234 Gene

Aliases for TMEM234 Gene

  • Transmembrane Protein 234 2 3 5
  • C1orf91 3 4
  • Chromosome 1 Open Reading Frame 91 2
  • RP4-622L5 3
  • DJ622L5.7 3
  • AASL548 3
  • PRO1105 3

External Ids for TMEM234 Gene

Previous HGNC Symbols for TMEM234 Gene

  • C1orf91

Previous GeneCards Identifiers for TMEM234 Gene

  • GC01M032681

Summaries for TMEM234 Gene

GeneCards Summary for TMEM234 Gene

TMEM234 (Transmembrane Protein 234) is a Protein Coding gene.

Additional gene information for TMEM234 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM234 Gene

Genomics for TMEM234 Gene

GeneHancer (GH) Regulatory Elements for TMEM234 Gene

Promoters and enhancers for TMEM234 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032220 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -151 4 FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 EIF3I PIR61377 TMEM234 GC01P032222 KPNA6
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +286.5 286526 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
GH01I032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -594.9 -594883 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS TXLNA TSSK3 RBBP4 ZBTB8A KHDRBS1 TMEM39B EIF3I FAM229A
GH01I032178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 +42.0 42014 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B TXLNA ENSG00000224066 IQCC DCDC2B SNRNP40 TSSK3 KPNA6 RBBP4 EIF3I TMEM234
GH01I031370 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +848.4 848358 7.4 ARID4B SIN3A ZNF48 ETS1 FOS ATF7 RXRA SP5 RFX3 GLIS1 FABP3 SERINC2 FAM229A TSSK3 SNRNP40 TMEM39B DCDC2B TMEM234 GC01M031377 GC01M031352
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM234 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM234 Gene

Genomic Locations for TMEM234 Gene
17,554 bases
Minus strand

Genomic View for TMEM234 Gene

Genes around TMEM234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM234 Gene

Proteins for TMEM234 Gene

  • Protein details for TMEM234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 234
    Protein Accession:
    Secondary Accessions:
    • B2R535
    • D3DPP7
    • Q6UWY9
    • Q8N2H6
    • Q9BSR2
    • Q9NU76

    Protein attributes for TMEM234 Gene

    164 amino acids
    Molecular mass:
    17601 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM234 Gene


neXtProt entry for TMEM234 Gene

Post-translational modifications for TMEM234 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM234 Gene

Domains & Families for TMEM234 Gene

Gene Families for TMEM234 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM234 Gene


Suggested Antigen Peptide Sequences for TMEM234 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM234 family.
  • Belongs to the TMEM234 family.
genes like me logo Genes that share domains with TMEM234: view

Function for TMEM234 Gene

Gene Ontology (GO) - Molecular Function for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM234: view
genes like me logo Genes that share phenotypes with TMEM234: view

Animal Models for TMEM234 Gene

MGI Knock Outs for TMEM234:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM234

CRISPR Products

miRNA for TMEM234 Gene

miRTarBase miRNAs that target TMEM234

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM234 Gene

Localization for TMEM234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM234 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM234 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM234: view

Pathways & Interactions for TMEM234 Gene

SuperPathways for TMEM234 Gene

No Data Available

Interacting Proteins for TMEM234 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WY98-TM234_HUMAN ENSP00000309792 for TMEM234 Gene via UniProtKB STRING MINT IID

Gene Ontology (GO) - Biological Process for TMEM234 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM234 Gene

Drugs & Compounds for TMEM234 Gene

No Compound Related Data Available

Transcripts for TMEM234 Gene

Unigene Clusters for TMEM234 Gene

Transmembrane protein 234:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM234 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP12: - - - - - - - -

Relevant External Links for TMEM234 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM234 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM234 Gene

Protein differential expression in normal tissues from HIPED for TMEM234 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM234 Gene

Protein tissue co-expression partners for TMEM234 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM234 Gene:


SOURCE GeneReport for Unigene cluster for TMEM234 Gene:


Evidence on tissue expression from TISSUES for TMEM234 Gene

  • Thyroid gland(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM234: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM234 Gene

Orthologs for TMEM234 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM234 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM234 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia TMEM234 33 34
  • 91.19 (n)
(Canis familiaris)
Mammalia TMEM234 33 34
  • 90.95 (n)
(Mus musculus)
Mammalia Tmem234 33 16 34
  • 85.99 (n)
(Monodelphis domestica)
Mammalia TMEM234 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM234 34
  • 52 (a)
(Gallus gallus)
Aves TMEM234 33
  • 65.35 (n)
(Anolis carolinensis)
Reptilia TMEM234 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem234 33
  • 59.71 (n)
(Danio rerio)
Actinopterygii tmem234 33 34
  • 59.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12929 33 34
  • 46.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta U546_ANOGA 33
  • 43.83 (n)
Species where no ortholog for TMEM234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM234 Gene

Gene Tree for TMEM234 (if available)
Gene Tree for TMEM234 (if available)

Paralogs for TMEM234 Gene

No data available for Paralogs for TMEM234 Gene

Variants for TMEM234 Gene

Sequence variations from dbSNP and Humsavar for TMEM234 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs140234450 benign, not specified 32,204,317(-) G/A downstream_transcript_variant
rs1000383939 -- 32,204,373(-) T/A downstream_transcript_variant
rs1000506821 -- 32,208,946(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000559671 -- 32,222,834(-) C/G upstream_transcript_variant
rs1000621551 -- 32,221,435(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM234 Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for TMEM234 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM234 Gene

Disorders for TMEM234 Gene

Additional Disease Information for TMEM234

No disorders were found for TMEM234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM234 Gene

Publications for TMEM234 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for TMEM234 Gene

Sources for TMEM234 Gene

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