Aliases for TMEM233 Gene

Aliases for TMEM233 Gene

  • Transmembrane Protein 233 2 3 4 5
  • Dispanin Subfamily B Member 2 2 3 4
  • Interferon-Induced Transmembrane Domain-Containing Protein D2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 2 2 3
  • IFITMD2 3 4
  • DSPB2 3 4

External Ids for TMEM233 Gene

Previous GeneCards Identifiers for TMEM233 Gene

  • GC12P118516
  • GC12P120031
  • GC12P117039

Summaries for TMEM233 Gene

GeneCards Summary for TMEM233 Gene

TMEM233 (Transmembrane Protein 233) is a Protein Coding gene. Diseases associated with TMEM233 include Osteogenesis Imperfecta, Type V. An important paralog of this gene is TRARG1.

Additional gene information for TMEM233 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM233 Gene

Genomics for TMEM233 Gene

GeneHancer (GH) Regulatory Elements for TMEM233 Gene

Promoters and enhancers for TMEM233 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM233 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM233

Genomic Locations for TMEM233 Gene

Genomic Locations for TMEM233 Gene
chr12:119,592,636-119,654,442
(GRCh38/hg38)
Size:
61,807 bases
Orientation:
Plus strand
chr12:120,031,264-120,079,363
(GRCh37/hg19)
Size:
48,100 bases
Orientation:
Plus strand

Genomic View for TMEM233 Gene

Genes around TMEM233 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM233 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM233 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM233 Gene

Proteins for TMEM233 Gene

  • Protein details for TMEM233 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DJY2-TM233_HUMAN
    Recommended name:
    Transmembrane protein 233
    Protein Accession:
    B4DJY2

    Protein attributes for TMEM233 Gene

    Size:
    109 amino acids
    Molecular mass:
    12074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM233 Gene

Post-translational modifications for TMEM233 Gene

  • Ubiquitination at Lys11
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM233 Gene

No data available for DME Specific Peptides for TMEM233 Gene

Domains & Families for TMEM233 Gene

Gene Families for TMEM233 Gene

Protein Domains for TMEM233 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM233 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-induced transmembrane domain-containing protein D2 (TM233_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B4DJY2

UniProtKB/Swiss-Prot:

TM233_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM233: view

Function for TMEM233 Gene

Phenotypes From GWAS Catalog for TMEM233 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM233

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM233 Gene

Localization for TMEM233 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM233 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM233 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM233: view

Pathways & Interactions for TMEM233 Gene

PathCards logo

SuperPathways for TMEM233 Gene

No Data Available

Interacting Proteins for TMEM233 Gene

;

Gene Ontology (GO) - Biological Process for TMEM233 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM233 Gene

Drugs & Compounds for TMEM233 Gene

No Compound Related Data Available

Transcripts for TMEM233 Gene

mRNA/cDNA for TMEM233 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM233

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM233 Gene

No ASD Table

Relevant External Links for TMEM233 Gene

GeneLoc Exon Structure for
TMEM233

Expression for TMEM233 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM233 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM233 Gene

This gene is overexpressed in Muscle - Skeletal (x37.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM233

SOURCE GeneReport for Unigene cluster for TMEM233 Gene:

Hs.530965

Evidence on tissue expression from TISSUES for TMEM233 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM233: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM233 Gene

Orthologs for TMEM233 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM233 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM233 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM233 31 30
  • 92.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM233 30
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Tmem233 17 31 30
  • 83.64 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM233 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM233 30
  • 71.87 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM233 31
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem233 30
  • 66.98 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885033 30
  • 57.93 (n)
BX005328.1 31
  • 47 (a)
OneToOne
Species where no ortholog for TMEM233 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM233 Gene

ENSEMBL:
Gene Tree for TMEM233 (if available)
TreeFam:
Gene Tree for TMEM233 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM233: view image

Paralogs for TMEM233 Gene

Paralogs for TMEM233 Gene

(1) SIMAP similar genes for TMEM233 Gene using alignment to 1 proteins:

  • TM233_HUMAN
genes like me logo Genes that share paralogs with TMEM233: view

Variants for TMEM233 Gene

Additional dbSNP identifiers (rs#s) for TMEM233 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM233 Gene

Variant ID Type Subtype PubMed ID
esv3630908 CNV gain 21293372
esv3630909 CNV gain 21293372
esv3630910 CNV loss 21293372
nsv832529 CNV loss 17160897

Variation tolerance for TMEM233 Gene

Gene Damage Index Score: 0.61; 13.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM233 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM233

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM233 Gene

Disorders for TMEM233 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM233 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type v
  • oi5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM233

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM233: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM233 Gene

Publications for TMEM233 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Benefits of random-priming: exhaustive survey of a cDNA library from lung tissue of a SARS patient. (PMID: 21328370) Wu H … Wang X (Journal of medical virology 2011) 3 54

Products for TMEM233 Gene

Sources for TMEM233 Gene