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Aliases for TMEM233 Gene
Aliases for TMEM233 Gene
External Ids for TMEM233 Gene
- HGNC: 37219
- Entrez Gene: 387890
- Ensembl: ENSG00000224982
- OMIM: 618296
- UniProtKB: B4DJY2
Previous GeneCards Identifiers for TMEM233 Gene
- GC12P118516
- GC12P120031
- GC12P117039
Summaries for TMEM233 Gene
GeneCards Summary for TMEM233 Gene
TMEM233 (Transmembrane Protein 233) is a Protein Coding gene. Diseases associated with TMEM233 include Osteogenesis Imperfecta, Type V and Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. An important paralog of this gene is TRARG1.
Additional gene information for TMEM233 Gene
- HGNC(37219)
- Entrez Gene(387890)
- Ensembl(ENSG00000224982)
- OMIM(618296)
- UniProtKB(B4DJY2)
- Open Targets Platform(ENSG00000224982)
- Search for TMEM233 at DataMed
- Search for TMEM233 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM233 Gene
Genomics for TMEM233 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMEM233 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMEM233 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM233
Genomic Locations for TMEM233 Gene
Genomic Locations for TMEM233 Gene
- chr12:119,592,123-119,654,455
- (GRCh38/hg38)
- Size:
- 62,333 bases
- Orientation:
- Plus strand
- chr12:120,031,264-120,079,363
- (GRCh37/hg19)
- Size:
- 48,100 bases
- Orientation:
- Plus strand
Genomic View for TMEM233 Gene
Genes around TMEM233 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.23 by HGNC
- 12q24.23 by Entrez Gene
- 12q24.23 by Ensembl
TMEM233 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM233 Gene
Proteins for TMEM233 Gene
-
Protein details for TMEM233 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- B4DJY2-TM233_HUMAN
- Recommended name:
- Transmembrane protein 233
- Protein Accession:
- B4DJY2
Protein attributes for TMEM233 Gene
- Size:
- 109 amino acids
- Molecular mass:
- 12074 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TMEM233 Gene
Other Protein References for TMEM233 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- antibodies-online: Show 11 available TMEM233 Antibodies ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM233
- Origene Custom Protein Services for TMEM233
No data available for DME Specific Peptides for TMEM233 Gene
Domains & Families for TMEM233 Gene
Gene Families for TMEM233 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TMEM233 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM233 Gene
- GenScript: Design optimal peptide antigens:
-
- Interferon-induced transmembrane domain-containing protein D2 (TM233_HUMAN)
Graphical View of Domain Structure for InterPro Entry
B4DJY2- Family:
-
- Belongs to the CD225/Dispanin family.
Function for TMEM233 Gene
Phenotypes From GWAS Catalog for TMEM233 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM233 - Select products 50% OFF >
- * TMEM233 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM233
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM233
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM233
miRNA for TMEM233 Gene
- miRTarBase miRNAs that target TMEM233
-
- hsa-miR-6867-3p (MIRT494969)
- hsa-miR-629-3p (MIRT494970)
- hsa-miR-4713-5p (MIRT494971)
- hsa-miR-4258 (MIRT494972)
- hsa-miR-374c-3p (MIRT494973)
- hsa-miR-5571-5p (MIRT494974)
- hsa-miR-1976 (MIRT621793)
- hsa-miR-3653-5p (MIRT621794)
- hsa-miR-6747-3p (MIRT621795)
- hsa-miR-6727-3p (MIRT621796)
- hsa-miR-4722-3p (MIRT621797)
- hsa-miR-6769b-3p (MIRT621798)
- hsa-miR-4723-3p (MIRT621799)
- hsa-miR-3183 (MIRT621800)
- hsa-miR-6885-3p (MIRT635116)
- hsa-miR-129-5p (MIRT635117)
- hsa-miR-2115-3p (MIRT635118)
- hsa-miR-449c-3p (MIRT635119)
- hsa-miR-296-3p (MIRT635120)
- hsa-miR-1206 (MIRT783127)
- hsa-miR-4776-3p (MIRT786737)
- hsa-miR-5009-5p (MIRT786971)
- hsa-miR-5696 (MIRT787808)
- hsa-miR-578 (MIRT787909)
- hsa-miR-579-3p (MIRT787918)
- hsa-miR-664b-3p (MIRT788439)
- hsa-miR-6853-3p (MIRT789085)
- hsa-miR-8058 (MIRT789769)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM233
- Browse OriGene Inhibitory RNA Products For TMEM233
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM233
Clone Products
- Applied Biological Materials (abm): Clones for TMEM233 - Select products 50% OFF >
- * TMEM233 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM233
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM233
Cell Line Products
-
Horizon Cell Lines for TMEM233
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM233 Gene
Localization for TMEM233 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM233 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for TMEM233 Gene
mRNA/cDNA for TMEM233 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000426426 2775 nts (view in UCSC)
- ENST00000453450 438 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM233 - Select products 50% OFF >
- * TMEM233 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM233
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM233
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM233
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM233
- Browse OriGene Inhibitory RNA Products For TMEM233
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM233
Clone Products
- Applied Biological Materials (abm): Clones for TMEM233 - Select products 50% OFF >
- * TMEM233 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM233
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM233
Relevant External Links for TMEM233 Gene
- GeneLoc Exon Structure for
- TMEM233
Expression for TMEM233 Gene
mRNA differential expression in normal tissues according to GTEx for TMEM233 Gene
This gene is overexpressed in Muscle - Skeletal (x37.6).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM233
SOURCE GeneReport for Unigene cluster for TMEM233 Gene:
Hs.530965Evidence on tissue expression from TISSUES for TMEM233 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for TMEM233
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM233 Gene
Orthologs for TMEM233 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMEM233 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TMEM233 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TMEM233 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tmem233 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TMEM233 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | TMEM233 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | TMEM233 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmem233 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101885033 30 |
|
||
| BX005328.1 31 |
|
OneToOne |
- Species where no ortholog for TMEM233 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TMEM233 Gene
- ENSEMBL:
- Gene Tree for TMEM233 (if available)
- TreeFam:
- Gene Tree for TMEM233 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM233: view image
Paralogs for TMEM233 Gene
Variants for TMEM233 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3630908 | CNV | gain | 21293372 |
| esv3630909 | CNV | gain | 21293372 |
| esv3630910 | CNV | loss | 21293372 |
| nsv832529 | CNV | loss | 17160897 |
Gene Damage Index Score:
0.61;
13.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM233 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM233
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM233 Gene
Disorders for TMEM233 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| osteogenesis imperfecta, type v |
|
|
| mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes |
|
|
Search TMEM233 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMEM233
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM233 Gene
Publications for TMEM233 Gene
- The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Benefits of random-priming: exhaustive survey of a cDNA library from lung tissue of a SARS patient. (PMID: 21328370) Wu H … Wang X (Journal of medical virology 2011) 3
ExternalLinks
Products for TMEM233 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM233
- Origene Custom Protein Services for TMEM233
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM233
- Browse OriGene Inhibitory RNA Products For TMEM233
- OriGene qPCR primer pairs for TMEM233
- OriGene CRISPR knockouts for TMEM233
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMEM233
- Sino Biological Human cDNA Clone for TMEM233
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for TMEM233 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMEM233 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMEM233 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMEM233 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMEM233
- antibodies-online: Show 11 available TMEM233 Antibodies ranked by validation data
- antibodies-online: Search results for available TMEM233 related products ranked by validation data
- antibodies-online: Search results for available TMEM233 related products ranked by validation data
- Horizon Cell Lines for TMEM233
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM233
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM233
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMEM233
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM233
Sources for TMEM233 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB