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Aliases for TMEM229A Gene

Aliases for TMEM229A Gene

  • Transmembrane Protein 229A 2 3 3 5

External Ids for TMEM229A Gene

Previous GeneCards Identifiers for TMEM229A Gene

  • GC07M123463
  • GC07M123670
  • GC07M118035

Summaries for TMEM229A Gene

GeneCards Summary for TMEM229A Gene

TMEM229A (Transmembrane Protein 229A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is TMEM229B.

Additional gene information for TMEM229A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM229A Gene

Genomics for TMEM229A Gene

GeneHancer (GH) Regulatory Elements for TMEM229A Gene

Promoters and enhancers for TMEM229A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J124031 Promoter/Enhancer 1.3 Ensembl ENCODE 650.7 +0.7 650 2.2 MZF1 SIN3A ZNF2 ETS1 ZNF335 GLIS2 SCRT2 RCOR1 EGR2 ZNF202 LOC102724577 TMEM229A
GH07J124072 Enhancer 0.8 ENCODE 11 -40.2 -40215 2.7 FOXA2 INSM2 FEZF1 ZEB1 ZNF366 RCOR1 FOS ZNF362 CEBPB ZNF398 PIR43907 TMEM229A LOC102724577 PIR39500
GH07J124084 Enhancer 0.5 ENCODE 11.8 -51.6 -51648 2 JUND GATA3 POLR2A JUN MAX RCOR1 CHD2 TMEM229A PIR43907 LOC102724577 PIR39500
GH07J124037 Enhancer 0.2 FANTOM5 7.8 -4.0 -3982 0 TMEM229A LOC102724577 PIR43907
GH07J124038 Enhancer 0.2 ENCODE 6 -5.0 -4995 0.6 TMEM229A LOC102724577 PIR43907
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM229A on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM229A Gene

Genomic Locations for TMEM229A Gene
2,554 bases
Minus strand
2,554 bases
Minus strand

Genomic View for TMEM229A Gene

Genes around TMEM229A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM229A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM229A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM229A Gene

Proteins for TMEM229A Gene

  • Protein details for TMEM229A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 229A
    Protein Accession:
    Secondary Accessions:
    • A4D0X6

    Protein attributes for TMEM229A Gene

    380 amino acids
    Molecular mass:
    42370 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAL24328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM229A Gene

Post-translational modifications for TMEM229A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM229A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM229A Gene

Domains & Families for TMEM229A Gene

Gene Families for TMEM229A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM229A Gene


Suggested Antigen Peptide Sequences for TMEM229A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM229 family.
  • Belongs to the TMEM229 family.
genes like me logo Genes that share domains with TMEM229A: view

Function for TMEM229A Gene

Phenotypes for TMEM229A Gene

genes like me logo Genes that share phenotypes with TMEM229A: view

Animal Model Products

miRNA for TMEM229A Gene

miRTarBase miRNAs that target TMEM229A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM229A Gene

Localization for TMEM229A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM229A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM229A gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM229A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM229A: view

Pathways & Interactions for TMEM229A Gene

SuperPathways for TMEM229A Gene

No Data Available

Interacting Proteins for TMEM229A Gene

Gene Ontology (GO) - Biological Process for TMEM229A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM229A Gene

Drugs & Compounds for TMEM229A Gene

No Compound Related Data Available

Transcripts for TMEM229A Gene

mRNA/cDNA for TMEM229A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM229A Gene

Transmembrane protein 229A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM229A Gene

No ASD Table

Relevant External Links for TMEM229A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM229A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM229A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM229A Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Spinal cord (cervical c-1) (x5.3), Brain - Putamen (basal ganglia) (x4.5), Brain - Hippocampus (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM229A Gene

This gene is overexpressed in Plasma (46.3) and Testis (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM229A Gene

Protein tissue co-expression partners for TMEM229A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM229A Gene:


SOURCE GeneReport for Unigene cluster for TMEM229A Gene:

genes like me logo Genes that share expression patterns with TMEM229A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM229A Gene

Orthologs for TMEM229A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM229A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM229A 34 33
  • 99.47 (n)
(Bos Taurus)
Mammalia TMEM229A 33
  • 88.4 (n)
(Mus musculus)
Mammalia Tmem229a 16 34 33
  • 84.82 (n)
(Canis familiaris)
Mammalia TMEM229A 34 33
  • 84.61 (n)
(Rattus norvegicus)
Mammalia Tmem229a 33
  • 84.37 (n)
(Monodelphis domestica)
Mammalia TMEM229A 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem229a 33
  • 64.97 (n)
(Danio rerio)
Actinopterygii LOC794725 33
  • 61.53 (n)
Species where no ortholog for TMEM229A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM229A Gene

Gene Tree for TMEM229A (if available)
Gene Tree for TMEM229A (if available)
Evolutionary constrained regions (ECRs) for TMEM229A: view image

Paralogs for TMEM229A Gene

Paralogs for TMEM229A Gene

(1) SIMAP similar genes for TMEM229A Gene using alignment to 1 proteins:

  • T229A_HUMAN
genes like me logo Genes that share paralogs with TMEM229A: view

Variants for TMEM229A Gene

Sequence variations from dbSNP and Humsavar for TMEM229A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000164968 -- 124,030,617(-) A/G downstream_transcript_variant
rs1000200121 -- 124,033,819(-) C/T upstream_transcript_variant
rs1000314449 -- 124,034,152(-) A/T upstream_transcript_variant
rs1000535897 -- 124,035,433(-) TTT/TTTT upstream_transcript_variant
rs1000567418 -- 124,034,882(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM229A Gene

Variant ID Type Subtype PubMed ID
nsv1145157 CNV deletion 24896259

Variation tolerance for TMEM229A Gene

Gene Damage Index Score: 8.50; 85.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM229A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM229A Gene

Disorders for TMEM229A Gene

Additional Disease Information for TMEM229A

No disorders were found for TMEM229A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM229A Gene

Publications for TMEM229A Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  2. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM229A Gene

Sources for TMEM229A Gene

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