Aliases for TMEM225 Gene

Aliases for TMEM225 Gene

  • Transmembrane Protein 225 2 3 4 5
  • PMP22CD 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 154 2 3
  • Spermatogenesis Associated 47 2 3
  • PPP1R154 2 3
  • SPATA47 2 3
  • PMP22 Claudin Domain-Containing Protein 3
  • PMP22 Claudin Domain Containing 2
  • TMEM225 5

External Ids for TMEM225 Gene

Previous GeneCards Identifiers for TMEM225 Gene

  • GC11M123260
  • GC11M123753
  • GC11M119693

Summaries for TMEM225 Gene

GeneCards Summary for TMEM225 Gene

TMEM225 (Transmembrane Protein 225) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TMEM225 Gene

  • Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM225 Gene

Genomics for TMEM225 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM225 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123885 Promoter 0.4 EPDnew 250.7 +0.2 245 0.1 NR2F6 TMEM225 OR6M3P OR6M1
GH11J124241 Enhancer 0.3 FANTOM5 79.3 -355.3 -355316 0.1 NFE2 OR8G1 TMEM225 SPA17 VWA5A NONHSAG009926.2 OR8G5 HSALNG0087874 lnc-OR8G5-6
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.9 +144.1 144127 4.4 BCLAF1 ZNF207 ZNF600 MYC NCOR1 POLR2A NFIC YY1 MXD4 REST ZNF202 lnc-ZNF202-1 lnc-GRAMD1B-6 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J123774 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.3 +110.1 110072 5.3 ETS1 MAFF ZNF316 MAFK PRDM10 TAF1 SP1 POU5F1 NANOG ZNF143 ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 HSALNG0087853 HSALNG0087854
GH11J123821 Enhancer 0.6 Ensembl ENCODE 9.8 +63.3 63299 1.5 CEBPB MEIS2 CEBPG TMEM225 OR6M1 OR6M2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM225 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM225

Top Transcription factor binding sites by QIAGEN in the TMEM225 gene promoter:
  • AML1a
  • C/EBPalpha
  • Chx10
  • GATA-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-6

Genomic Locations for TMEM225 Gene

Latest Assembly
3,004 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,751 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,717 bases
Minus strand

Genomic View for TMEM225 Gene

Genes around TMEM225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM225 Gene

Proteins for TMEM225 Gene

  • Protein details for TMEM225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 225
    Protein Accession:

    Protein attributes for TMEM225 Gene

    225 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    • Interacts (via RVxF motif) with PPP1CC.

neXtProt entry for TMEM225 Gene

Post-translational modifications for TMEM225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM225 Gene

No data available for DME Specific Peptides for TMEM225 Gene

Domains & Families for TMEM225 Gene

Gene Families for TMEM225 Gene

Protein Domains for TMEM225 Gene


Suggested Antigen Peptide Sequences for TMEM225 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 225 (TM225_HUMAN)
genes like me logo Genes that share domains with TMEM225: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM225 Gene

Function for TMEM225 Gene

Molecular function for TMEM225 Gene

UniProtKB/Swiss-Prot Function:
Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.

Phenotypes From GWAS Catalog for TMEM225 Gene

genes like me logo Genes that share phenotypes with TMEM225: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM225

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM225 Gene

Localization for TMEM225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM225 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM225 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM225 Gene

Pathways & Interactions for TMEM225 Gene

PathCards logo

SuperPathways for TMEM225 Gene

No Data Available

Interacting Proteins for TMEM225 Gene

Selected Interacting proteins: Q6GV28-TM225_HUMAN for TMEM225 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IEA,IDA 19389623
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM225 Gene

Drugs & Compounds for TMEM225 Gene

No Compound Related Data Available

Transcripts for TMEM225 Gene

mRNA/cDNA for TMEM225 Gene

3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM225

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM225 Gene

No ASD Table

Relevant External Links for TMEM225 Gene

GeneLoc Exon Structure for

Expression for TMEM225 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM225 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM225 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for TMEM225 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM225 Gene

Protein tissue co-expression partners for TMEM225 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM225

SOURCE GeneReport for Unigene cluster for TMEM225 Gene:

genes like me logo Genes that share expression patterns with TMEM225: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM225 Gene

Orthologs for TMEM225 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM225 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM225 29 30
  • 97.78 (n)
(Canis familiaris)
Mammalia TMEM225 29 30
  • 72.92 (n)
(Bos Taurus)
Mammalia TMEM225 29 30
  • 69.96 (n)
(Mus musculus)
Mammalia Tmem225 29 16 30
  • 66.07 (n)
(Rattus norvegicus)
Mammalia Tmem225 29
  • 65.62 (n)
(Monodelphis domestica)
Mammalia TMEM225 30
  • 25 (a)
Species where no ortholog for TMEM225 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMEM225 Gene

Gene Tree for TMEM225 (if available)
Gene Tree for TMEM225 (if available)
Evolutionary constrained regions (ECRs) for TMEM225: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM225

Paralogs for TMEM225 Gene

No data available for Paralogs for TMEM225 Gene

Variants for TMEM225 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM225 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10893099 -- p.Asn134Ser
rs1939927 -- p.Cys196Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM225 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TMEM225 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM225 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM225 Gene

Disorders for TMEM225 Gene

Additional Disease Information for TMEM225

No disorders were found for TMEM225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM225 Gene

Publications for TMEM225 Gene

  1. TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa. (PMID: 25605614) Matsuura M … Yogo K (Molecular reproduction and development 2015) 2 3
  2. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 40

Products for TMEM225 Gene

Sources for TMEM225 Gene