Aliases for TMEM223 Gene

Aliases for TMEM223 Gene

  • Transmembrane Protein 223 2 3 4 5
  • TMEM223 5
  • MGC3196 2

External Ids for TMEM223 Gene

Previous GeneCards Identifiers for TMEM223 Gene

  • GC11M062315
  • GC11M062557
  • GC11M058886
  • GC11M062540
  • GC11M062772
  • GC11M062965
  • GC11M062995
  • GC11M063019
  • GC11M063084
  • GC11M062773
  • GC11M062788
  • GC11M062789
  • GC11M062827
  • GC11M062849
  • GC11M063446

Summaries for TMEM223 Gene

GeneCards Summary for TMEM223 Gene

TMEM223 (Transmembrane Protein 223) is a Protein Coding gene.

Additional gene information for TMEM223 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM223 Gene

Genomics for TMEM223 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM223 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM223 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM223

Top Transcription factor binding sites by QIAGEN in the TMEM223 gene promoter:
  • AML1a
  • Bach2
  • Brachyury
  • GATA-2
  • HNF-1
  • HNF-1A
  • Lmo2
  • NRSF form 1
  • NRSF form 2
  • RREB-1

Genomic Locations for TMEM223 Gene

Latest Assembly
chr11:62,771,629-62,792,006
(GRCh38/hg38)
Size:
20,378 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,557,443-62,559,478
(GRCh37/hg19 by Entrez Gene)
Size:
2,036 bases
Orientation:
Minus strand

chr11:62,539,101-62,559,493
(GRCh37/hg19 by Ensembl)
Size:
20,393 bases
Orientation:
Minus strand

Genomic View for TMEM223 Gene

Genes around TMEM223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM223 Gene

Proteins for TMEM223 Gene

  • Protein details for TMEM223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJW6-TM223_HUMAN
    Recommended name:
    Transmembrane protein 223
    Protein Accession:
    A0PJW6
    Secondary Accessions:
    • Q504S0
    • Q86YD4
    • Q8WUC5
    • Q96HG0

    Protein attributes for TMEM223 Gene

    Size:
    202 amino acids
    Molecular mass:
    22049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20914.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM223 Gene

Post-translational modifications for TMEM223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM223 Gene

No data available for DME Specific Peptides for TMEM223 Gene

Domains & Families for TMEM223 Gene

Gene Families for TMEM223 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM223 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM223 Gene

GenScript: Design optimal peptide antigens:
  • PDHA1/LOC79064 protein (A5PHJ9_HUMAN)
  • Transmembrane protein 223 (TM223_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0PJW6

UniProtKB/Swiss-Prot:

TM223_HUMAN :
  • Belongs to the TMEM223 family.
Family:
  • Belongs to the TMEM223 family.
genes like me logo Genes that share domains with TMEM223: view

Function for TMEM223 Gene

Phenotypes From GWAS Catalog for TMEM223 Gene

genes like me logo Genes that share phenotypes with TMEM223: view

miRNA for TMEM223 Gene

miRTarBase miRNAs that target TMEM223

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM223

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM223 Gene

Localization for TMEM223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM223 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM223 gene
Compartment Confidence
mitochondrion 3
plasma membrane 1
nucleus 1
extracellular 0
endoplasmic reticulum 0
cytosol 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM223: view

Pathways & Interactions for TMEM223 Gene

PathCards logo

SuperPathways for TMEM223 Gene

No Data Available

Interacting Proteins for TMEM223 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000303987 A0PJW6-TM223_HUMAN for TMEM223 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IBA 21873635
genes like me logo Genes that share ontologies with TMEM223: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM223 Gene

Drugs & Compounds for TMEM223 Gene

No Compound Related Data Available

Transcripts for TMEM223 Gene

mRNA/cDNA for TMEM223 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM223

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM223 Gene

No ASD Table

Relevant External Links for TMEM223 Gene

GeneLoc Exon Structure for
TMEM223

Expression for TMEM223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM223 Gene

Protein differential expression in normal tissues from HIPED for TMEM223 Gene

This gene is overexpressed in Urine (40.3) and Bone (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM223 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM223

SOURCE GeneReport for Unigene cluster for TMEM223 Gene:

Hs.530463

Evidence on tissue expression from TISSUES for TMEM223 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TMEM223: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM223 Gene

Orthologs for TMEM223 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM223 Gene

Organism Taxonomy Gene Similarity Type Details
Rat
(Rattus norvegicus)
Mammalia LOC100911695 30
  • 99.83 (n)
Chimpanzee
(Pan troglodytes)
Mammalia TMEM223 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM223 30 31
  • 83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM223 30 31
  • 82.34 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem223 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM223 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM223 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem223 30
  • 55.97 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem223 30 31
  • 51.42 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005148 30
  • 47.54 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12935 30 31
  • 46.29 (n)
OneToOne
Species where no ortholog for TMEM223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM223 Gene

ENSEMBL:
Gene Tree for TMEM223 (if available)
TreeFam:
Gene Tree for TMEM223 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM223: view image

Paralogs for TMEM223 Gene

(1) SIMAP similar genes for TMEM223 Gene using alignment to 3 proteins:

  • TM223_HUMAN
  • G5EA27_HUMAN
  • H0YCK4_HUMAN
genes like me logo Genes that share paralogs with TMEM223: view

No data available for Paralogs for TMEM223 Gene

Variants for TMEM223 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM223 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11827177 - p.Val196Gly
rs2584918 - p.Thr28Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM223 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM223 Gene

Variant ID Type Subtype PubMed ID
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Variation tolerance for TMEM223 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM223

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM223 Gene

Disorders for TMEM223 Gene

Additional Disease Information for TMEM223

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TMEM223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM223 Gene

Publications for TMEM223 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3

Products for TMEM223 Gene

Sources for TMEM223 Gene