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Aliases for TMEM222 Gene

Aliases for TMEM222 Gene

  • Transmembrane Protein 222 2 3 5
  • C1orf160 3 4
  • Chromosome 1 Open Reading Frame 160 2

External Ids for TMEM222 Gene

Previous HGNC Symbols for TMEM222 Gene

  • C1orf160

Previous GeneCards Identifiers for TMEM222 Gene

  • GC01P027523
  • GC01P027648
  • GC01P025904

Summaries for TMEM222 Gene

GeneCards Summary for TMEM222 Gene

TMEM222 (Transmembrane Protein 222) is a Protein Coding gene.

Gene Wiki entry for TMEM222 Gene

Additional gene information for TMEM222 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM222 Gene

Genomics for TMEM222 Gene

GeneHancer (GH) Regulatory Elements for TMEM222 Gene

Promoters and enhancers for TMEM222 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I027321 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 506 2.2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ACTG1P20 TMEM222 SYTL1
GH01I026691 Promoter/Enhancer 3.3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.7 -625.1 -625087 12.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ARID1A LOC101928728 HMGN2 ACTG1P20 PIGV LOC101928324 GPN2 GPATCH3 TMEM222 RPL17P9
GH01I027559 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +247.0 247038 19.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ACTG1P20 ARID1A TMEM222 GPN2 TRNAU1AP NPM1P39 EYA3 MAP3K6 AHDC1 FAM76A
GH01I027348 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 21.9 +28.3 28281 3 PKNOX1 ARID4B SIN3A GLIS2 ZNF143 ATF7 ZNF263 SP3 NFYC REST TMEM222 ENSG00000231207 GPR3 RNU6-48P ACTG1P20 ENSG00000243659 WDTC1 GC01P027353 SYTL1
GH01I027614 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +303.7 303693 23.4 HDGF PKNOX1 FOXA2 SMAD1 SIN3A YBX1 IRF4 ZNF121 ZNF207 ZNF143 FGR ACTG1P20 ARID1A EYA3 FAM76A TRNAU1AP NPM1P39 THEMIS2 PTAFR SNHG12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM222 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM222 gene promoter:

Genomic Locations for TMEM222 Gene

Genomic Locations for TMEM222 Gene
chr1:27,322,145-27,336,400
(GRCh38/hg38)
Size:
14,256 bases
Orientation:
Plus strand
chr1:27,648,636-27,662,891
(GRCh37/hg19)

Genomic View for TMEM222 Gene

Genes around TMEM222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM222 Gene

Proteins for TMEM222 Gene

  • Protein details for TMEM222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R3-TM222_HUMAN
    Recommended name:
    Transmembrane protein 222
    Protein Accession:
    Q9H0R3
    Secondary Accessions:
    • D3DPL6
    • Q53HD8
    • Q5FVE9

    Protein attributes for TMEM222 Gene

    Size:
    208 amino acids
    Molecular mass:
    23230 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66618.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM222 Gene

Post-translational modifications for TMEM222 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM222 Gene

Domains & Families for TMEM222 Gene

Gene Families for TMEM222 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM222 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM222: view

No data available for UniProtKB/Swiss-Prot for TMEM222 Gene

Function for TMEM222 Gene

Phenotypes From GWAS Catalog for TMEM222 Gene

genes like me logo Genes that share phenotypes with TMEM222: view

Animal Model Products

miRNA for TMEM222 Gene

miRTarBase miRNAs that target TMEM222

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM222 Gene

Localization for TMEM222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM222 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM222 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM222: view

Pathways & Interactions for TMEM222 Gene

SuperPathways for TMEM222 Gene

No Data Available

Interacting Proteins for TMEM222 Gene

Gene Ontology (GO) - Biological Process for TMEM222 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM222 Gene

Drugs & Compounds for TMEM222 Gene

No Compound Related Data Available

Transcripts for TMEM222 Gene

Unigene Clusters for TMEM222 Gene

Transmembrane protein 222:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM222 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for TMEM222 Gene

GeneLoc Exon Structure for
TMEM222
ECgene alternative splicing isoforms for
TMEM222

Expression for TMEM222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM222 Gene

Protein differential expression in normal tissues from HIPED for TMEM222 Gene

This gene is overexpressed in Frontal cortex (12.8), Peripheral blood mononuclear cells (8.6), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM222 Gene



Protein tissue co-expression partners for TMEM222 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM222 Gene:

TMEM222

SOURCE GeneReport for Unigene cluster for TMEM222 Gene:

Hs.469171

Evidence on tissue expression from TISSUES for TMEM222 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TMEM222: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM222 Gene

Orthologs for TMEM222 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM222 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM222 33 34
  • 93.75 (n)
dog
(Canis familiaris)
Mammalia TMEM222 33 34
  • 91.19 (n)
rat
(Rattus norvegicus)
Mammalia Tmem222 33
  • 89.9 (n)
mouse
(Mus musculus)
Mammalia Tmem222 33 16 34
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM222 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM222 33 34
  • 79.33 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM222 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem222 33
  • 67.22 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem222a 33 34
  • 72.03 (n)
tmem222b 34
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8372 33 34
  • 68.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012042 33
  • 62.24 (n)
worm
(Caenorhabditis elegans)
Secernentea H20J04.6 33 34
  • 58.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RTH 33
  • 49.51 (n)
rice
(Oryza sativa)
Liliopsida Os03g0799500 33
  • 53.91 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14692 33
Species where no ortholog for TMEM222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM222 Gene

ENSEMBL:
Gene Tree for TMEM222 (if available)
TreeFam:
Gene Tree for TMEM222 (if available)

Paralogs for TMEM222 Gene

No data available for Paralogs for TMEM222 Gene

Variants for TMEM222 Gene

Sequence variations from dbSNP and Humsavar for TMEM222 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000068306 -- 27,327,431(+) C/T intron_variant
rs1000497048 -- 27,328,118(+) G/A intron_variant
rs1001073219 -- 27,322,724(+) T/G intron_variant
rs1001334177 -- 27,323,859(+) T/C intron_variant
rs1001397809 -- 27,325,109(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM222 Gene

Variant ID Type Subtype PubMed ID
nsv945850 CNV duplication 23825009
nsv526051 CNV gain 19592680
nsv516766 CNV loss 19592680

Variation tolerance for TMEM222 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM222 Gene

Human Gene Mutation Database (HGMD)
TMEM222
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM222 Gene

Disorders for TMEM222 Gene

Additional Disease Information for TMEM222

No disorders were found for TMEM222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM222 Gene

Publications for TMEM222 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM222 Gene

Sources for TMEM222 Gene

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