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Aliases for TMEM221 Gene

Aliases for TMEM221 Gene

  • Transmembrane Protein 221 2 3 5

External Ids for TMEM221 Gene

Previous GeneCards Identifiers for TMEM221 Gene

  • GC19M017409
  • GC19M017547
  • GC19M017112

Summaries for TMEM221 Gene

GeneCards Summary for TMEM221 Gene

TMEM221 (Transmembrane Protein 221) is a Protein Coding gene. An important paralog of this gene is ENSG00000269035.

Additional gene information for TMEM221 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM221 Gene

Genomics for TMEM221 Gene

GeneHancer (GH) Regulatory Elements for TMEM221 Gene

Promoters and enhancers for TMEM221 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017448 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.1 59 0.8 HDAC1 RB1 ZNF335 ZNF121 GLIS2 EGR1 SP3 ZNF398 ZFP69B MTA1 TMEM221 LOC100507551 ENSG00000269035 ENSG00000269481
GH19I017441 Enhancer 0.9 Ensembl ENCODE 16.9 +6.9 6851 1.2 CTCF ZNF146 ATF1 ZNF792 ASH1L PYGO2 RAD21 RFX5 ZNF280A FOXM1 TMEM221 ENSG00000269427 SMIM7 ENSG00000269044 ENSG00000269481 ENSG00000269035
GH19I017449 Enhancer 1.1 Ensembl ENCODE 0.8 -2.1 -2132 1.6 PKNOX1 ATF1 ZNF302 FOS RUNX3 DEK SP3 JUNB MAFF GMEB1 ENSG00000269427 CHERP GTPBP3 ENSG00000267904 ENSG00000268087 SLC27A1 ENSG00000269736 TMEM221 ENSG00000269035
GH19I017424 Enhancer 1.1 Ensembl ENCODE 0.3 +23.6 23613 0.8 PKNOX1 ATF1 ARNT SIN3A GLI4 ZNF2 GLIS2 ARID2 ZNF143 ATF7 BISPR ENSG00000269481 MVB12A TMEM221
GH19I017440 Enhancer 0.2 ENCODE 0.4 +7.8 7822 0.1 TMEM221 ENSG00000269481 ENSG00000269035
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM221 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM221 gene promoter:

Genomic Locations for TMEM221 Gene

Genomic Locations for TMEM221 Gene
chr19:17,435,509-17,448,660
(GRCh38/hg38)
Size:
13,152 bases
Orientation:
Minus strand
chr19:17,546,318-17,559,376
(GRCh37/hg19)

Genomic View for TMEM221 Gene

Genes around TMEM221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM221 Gene

Proteins for TMEM221 Gene

  • Protein details for TMEM221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGB7-TM221_HUMAN
    Recommended name:
    Transmembrane protein 221
    Protein Accession:
    A6NGB7

    Protein attributes for TMEM221 Gene

    Size:
    291 amino acids
    Molecular mass:
    30293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM221 Gene

Post-translational modifications for TMEM221 Gene

No Post-translational modifications

Other Protein References for TMEM221 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM221 Gene

Domains & Families for TMEM221 Gene

Gene Families for TMEM221 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM221 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM221: view

No data available for UniProtKB/Swiss-Prot for TMEM221 Gene

Function for TMEM221 Gene

Phenotypes for TMEM221 Gene

GenomeRNAi human phenotypes for TMEM221:
genes like me logo Genes that share phenotypes with TMEM221: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM221 Gene

Localization for TMEM221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM221 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM221 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM221: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM221 Gene

Pathways & Interactions for TMEM221 Gene

SuperPathways for TMEM221 Gene

No Data Available

Interacting Proteins for TMEM221 Gene

Gene Ontology (GO) - Biological Process for TMEM221 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM221 Gene

Drugs & Compounds for TMEM221 Gene

No Compound Related Data Available

Transcripts for TMEM221 Gene

mRNA/cDNA for TMEM221 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM221 Gene

Transmembrane protein 221:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM221 Gene

No ASD Table

Relevant External Links for TMEM221 Gene

GeneLoc Exon Structure for
TMEM221
ECgene alternative splicing isoforms for
TMEM221

Expression for TMEM221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM221 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM221 Gene

This gene is overexpressed in Ovary (x10.7) and Adrenal Gland (x5.9).

Protein differential expression in normal tissues from HIPED for TMEM221 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM221 Gene



Protein tissue co-expression partners for TMEM221 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM221 Gene:

TMEM221

SOURCE GeneReport for Unigene cluster for TMEM221 Gene:

Hs.436603
genes like me logo Genes that share expression patterns with TMEM221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM221 Gene

Orthologs for TMEM221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM221 33
  • 90.08 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
OneToMany
TMEM221 33
  • 86.83 (n)
cow
(Bos Taurus)
Mammalia TMEM221 33
  • 82.7 (n)
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem221 33
  • 77.13 (n)
mouse
(Mus musculus)
Mammalia Tmem221 33 16 34
  • 76.23 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TMEM221 34
  • 34 (a)
OneToMany
Species where no ortholog for TMEM221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM221 Gene

ENSEMBL:
Gene Tree for TMEM221 (if available)
TreeFam:
Gene Tree for TMEM221 (if available)

Paralogs for TMEM221 Gene

Paralogs for TMEM221 Gene

genes like me logo Genes that share paralogs with TMEM221: view

Variants for TMEM221 Gene

Sequence variations from dbSNP and Humsavar for TMEM221 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000017887 -- 17,449,619(-) G/A upstream_transcript_variant
rs1000226568 -- 17,445,724(-) A/C/G intron_variant
rs1000280481 -- 17,439,988(-) A/G intron_variant
rs1000348743 -- 17,440,156(-) C/A intron_variant
rs1000353612 -- 17,440,946(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM221 Gene

Variant ID Type Subtype PubMed ID
nsv833768 CNV loss 17160897

Variation tolerance for TMEM221 Gene

Gene Damage Index Score: 1.97; 36.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM221

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM221 Gene

Disorders for TMEM221 Gene

Additional Disease Information for TMEM221

No disorders were found for TMEM221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM221 Gene

Publications for TMEM221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy KW … Pang CP (Physiological genomics 2006) 3 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM221 Gene

Sources for TMEM221 Gene

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