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Aliases for TMEM214 Gene

Aliases for TMEM214 Gene

  • Transmembrane Protein 214 2 3 5

External Ids for TMEM214 Gene

Previous GeneCards Identifiers for TMEM214 Gene

  • GC02P027110
  • GC02P027255

Summaries for TMEM214 Gene

GeneCards Summary for TMEM214 Gene

TMEM214 (Transmembrane Protein 214) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM214 Gene

  • Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

Additional gene information for TMEM214 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM214 Gene

Genomics for TMEM214 Gene

GeneHancer (GH) Regulatory Elements for TMEM214 Gene

Promoters and enhancers for TMEM214 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027031 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 257 2.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF207 GC02M027029 TMEM214 KHK EMILIN1 SLC5A6 ATRAID AGBL5
GH02I027069 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.9 +43.6 43588 14.9 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 EMILIN1 OST4 CAD GTF3C2 SNX17 NRBP1 LOC105374363 GPN1 KHK TMEM214
GH02I027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.9 +630.7 630740 2.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SUPT7L SLC4A1AP IFT172 GTF3C2 CAD ZNF512 GPN1 NRBP1 EIF2B4 SNX17
GH02I026342 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.1 -687.1 -687136 6.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ADGRF3 SELENOI CAD ASXL2 TMEM214 GTF3C2-AS1 ENSG00000272148 AGBL5 KIF3C GAREM2
GH02I026242 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 -788.1 -788091 5.5 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPARGC1A HADHA HADHB CAD TMEM214 DNMT3A ASXL2 ATRAID RPS2P15 GAREM2 LOC105374334
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM214 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM214 gene promoter:

Genomic Locations for TMEM214 Gene

Genomic Locations for TMEM214 Gene
8,792 bases
Plus strand

Genomic View for TMEM214 Gene

Genes around TMEM214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM214 Gene

Proteins for TMEM214 Gene

  • Protein details for TMEM214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 214
    Protein Accession:
    Secondary Accessions:
    • A6NNF2
    • B3KUI9
    • B5MCD8
    • D6W547
    • Q53SW1
    • Q69YH4
    • Q8NC45
    • Q8WZ37
    • Q9NXH2

    Protein attributes for TMEM214 Gene

    689 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    • Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
    • Sequence=AAL55739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11331.1; Type=Frameshift; Positions=94; Evidence={ECO:0000305}; Sequence=CAH10591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM214 Gene


neXtProt entry for TMEM214 Gene

Post-translational modifications for TMEM214 Gene

  • Ubiquitination at posLast=240240, posLast=444444, and posLast=453453
  • Glycosylation at isoforms=2269 and posLast=307307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM214 Gene

Domains & Families for TMEM214 Gene

Gene Families for TMEM214 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM214 Gene


Suggested Antigen Peptide Sequences for TMEM214 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM214 family.
  • Belongs to the TMEM214 family.
genes like me logo Genes that share domains with TMEM214: view

Function for TMEM214 Gene

Molecular function for TMEM214 Gene

UniProtKB/Swiss-Prot Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for TMEM214 Gene

Phenotypes for TMEM214 Gene

genes like me logo Genes that share phenotypes with TMEM214: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM214 Gene

Localization for TMEM214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM214 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM214 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with TMEM214: view

Pathways & Interactions for TMEM214 Gene

SuperPathways for TMEM214 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TMEM214: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM214 Gene

Drugs & Compounds for TMEM214 Gene

No Compound Related Data Available

Transcripts for TMEM214 Gene

Unigene Clusters for TMEM214 Gene

Transmembrane protein 214:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM214 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20

Relevant External Links for TMEM214 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM214 Gene

Protein differential expression in normal tissues from HIPED for TMEM214 Gene

This gene is overexpressed in Bone (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM214 Gene

Protein tissue co-expression partners for TMEM214 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM214 Gene:


SOURCE GeneReport for Unigene cluster for TMEM214 Gene:


Evidence on tissue expression from TISSUES for TMEM214 Gene

  • Nervous system(4.6)
  • Intestine(4.4)
  • Stomach(4.3)
  • Skin(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TMEM214: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM214 Gene

Orthologs for TMEM214 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM214 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM214 34 33
  • 99.32 (n)
(Bos Taurus)
Mammalia TMEM214 33 34
  • 88.31 (n)
(Canis familiaris)
Mammalia TMEM214 33 34
  • 86.49 (n)
(Rattus norvegicus)
Mammalia Tmem214 33
  • 83.8 (n)
(Mus musculus)
Mammalia Tmem214 16 34 33
  • 83.65 (n)
(Monodelphis domestica)
Mammalia TMEM214 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM214 34
  • 69 (a)
(Gallus gallus)
Aves TMEM214 33 34
  • 65.46 (n)
(Anolis carolinensis)
Reptilia TMEM214 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8215 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6069 33
(Danio rerio)
Actinopterygii tmem214 33 34
  • 60.14 (n)
Dr.4892 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009823 33
  • 44.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33129 33 34
  • 43.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5886 34
  • 26 (a)
Species where no ortholog for TMEM214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM214 Gene

Gene Tree for TMEM214 (if available)
Gene Tree for TMEM214 (if available)

Paralogs for TMEM214 Gene

(1) SIMAP similar genes for TMEM214 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM214: view

No data available for Paralogs for TMEM214 Gene

Variants for TMEM214 Gene

Sequence variations from dbSNP and Humsavar for TMEM214 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000071269 -- 27,038,304(+) C/T intron_variant
rs1000124712 -- 27,038,650(+) G/C intron_variant
rs1000723320 -- 27,032,943(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000901104 -- 27,031,798(+) T/A upstream_transcript_variant
rs1001126094 -- 27,033,496(+) GAG/GAGAG genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM214 Gene

Variant ID Type Subtype PubMed ID
dgv6744n54 CNV loss 21841781
nsv455974 CNV loss 19166990
nsv817673 CNV gain 17921354

Variation tolerance for TMEM214 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM214 Gene

Disorders for TMEM214 Gene

Additional Disease Information for TMEM214

No disorders were found for TMEM214 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM214 Gene

Publications for TMEM214 Gene

  1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. (PMID: 23661706) Li C … Shu HB (The Journal of biological chemistry 2013) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM214 Gene

Sources for TMEM214 Gene

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