Aliases for TMEM213 Gene

Aliases for TMEM213 Gene

  • Transmembrane Protein 213 2 3 4 5

External Ids for TMEM213 Gene

Previous GeneCards Identifiers for TMEM213 Gene

  • GC07P138134
  • GC07P138482
  • GC07P132793

Summaries for TMEM213 Gene

GeneCards Summary for TMEM213 Gene

TMEM213 (Transmembrane Protein 213) is a Protein Coding gene.

Additional gene information for TMEM213 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM213 Gene

Genomics for TMEM213 Gene

GeneHancer (GH) Regulatory Elements for TMEM213 Gene

Promoters and enhancers for TMEM213 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J138797 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 750.6 +0.3 258 0.5 CTCF ZFP64 SIN3A ATP6V0A4 TMEM213 lnc-ATP6V0A4-1
GH07J138841 Enhancer 0.8 Ensembl ENCODE 11.6 +45.2 45229 2.5 L3MBTL2 TEAD4 MAFK SMARCA4 IKZF1 PKNOX1 ZNF316 EP300 NFE2 MGA HSALNG0061686 RNU6-1272P ATP6V0A4 TMEM213 ZC3HAV1L piR-50004 KIAA1549
GH07J139724 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 5.6 +928.7 928685 3.9 ZNF701 RAD21 SP1 SP7 ZSCAN21 ZNF548 IKZF1 RXRA ZNF639 TRIM22 SLC37A3 LUC7L2 ZC3HAV1L PARP12 HIPK2 TMEM213 TBXAS1 KDM7A piR-43041 RF00994-1037
GH07J138837 Enhancer 0.4 Ensembl ENCODE 11.3 +40.5 40482 1.3 RNF2 ATP6V0A4 TMEM213 RNU6-1272P piR-50004 HSALNG0061686 KIAA1549
GH07J138848 Enhancer 0.3 Ensembl 11.5 +50.4 50386 0.2 NFE2 CEBPG RNU6-1272P ATP6V0A4 TMEM213 ZC3HAV1L HSALNG0061686 RF00017-6672 KIAA1549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM213 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM213 gene promoter:
  • AML1a
  • GR
  • GR-alpha
  • GR-beta
  • HNF-1
  • HNF-1A
  • SEF-1 (1)
  • Zic1
  • ZIC2
  • Zic3

Genomic Locations for TMEM213 Gene

Genomic Locations for TMEM213 Gene
chr7:138,797,915-138,838,101
(GRCh38/hg38)
Size:
40,187 bases
Orientation:
Plus strand
chr7:138,482,695-138,522,846
(GRCh37/hg19)
Size:
40,152 bases
Orientation:
Plus strand

Genomic View for TMEM213 Gene

Genes around TMEM213 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM213 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM213 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM213 Gene

Proteins for TMEM213 Gene

  • Protein details for TMEM213 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RRL7-TM213_HUMAN
    Recommended name:
    Transmembrane protein 213
    Protein Accession:
    A2RRL7
    Secondary Accessions:
    • A4D1R3
    • C9JH49
    • C9JX41
    • C9K0P0

    Protein attributes for TMEM213 Gene

    Size:
    107 amino acids
    Molecular mass:
    11520 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31698.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM213 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM213 Gene

Post-translational modifications for TMEM213 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM213 Gene

No data available for DME Specific Peptides for TMEM213 Gene

Domains & Families for TMEM213 Gene

Gene Families for TMEM213 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM213 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM213 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 213 (TM213_HUMAN)
genes like me logo Genes that share domains with TMEM213: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM213 Gene

Function for TMEM213 Gene

genes like me logo Genes that share phenotypes with TMEM213: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM213 Gene

Localization for TMEM213 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM213 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM213 gene
Compartment Confidence
extracellular 3
lysosome 1
golgi apparatus 1
plasma membrane 0

Gene Ontology (GO) - Cellular Components for TMEM213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM213: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM213 Gene

Pathways & Interactions for TMEM213 Gene

PathCards logo

SuperPathways for TMEM213 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM213 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM213 Gene

Drugs & Compounds for TMEM213 Gene

No Compound Related Data Available

Transcripts for TMEM213 Gene

mRNA/cDNA for TMEM213 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM213 Gene

No ASD Table

Relevant External Links for TMEM213 Gene

GeneLoc Exon Structure for
TMEM213
ECgene alternative splicing isoforms for
TMEM213

Expression for TMEM213 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM213 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM213 Gene

This gene is overexpressed in Kidney - Cortex (x37.7), Minor Salivary Gland (x4.2), Skin - Not Sun Exposed (Suprapubic) (x4.1), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM213 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM213 Gene



Protein tissue co-expression partners for TMEM213 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM213 Gene:

TMEM213

SOURCE GeneReport for Unigene cluster for TMEM213 Gene:

Hs.567729
genes like me logo Genes that share expression patterns with TMEM213: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM213 Gene

Orthologs for TMEM213 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM213 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM213 33 32
  • 99.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM213 33 32
  • 84.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM213 33 32
  • 82.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem213 32
  • 77.99 (n)
mouse
(Mus musculus)
Mammalia Tmem213 17 33 32
  • 77.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM213 33
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM213 33 32
  • 75.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM213 33
  • 74 (a)
OneToOne
Species where no ortholog for TMEM213 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM213 Gene

ENSEMBL:
Gene Tree for TMEM213 (if available)
TreeFam:
Gene Tree for TMEM213 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM213: view image

Paralogs for TMEM213 Gene

No data available for Paralogs for TMEM213 Gene

Variants for TMEM213 Gene

Sequence variations from dbSNP and Humsavar for TMEM213 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs199654929 likely-benign, Distal Renal Tubular Acidosis, Recessive 138,798,082(+) G/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs200591064 uncertain-significance, Distal Renal Tubular Acidosis, Recessive 138,798,153(+) G/C coding_sequence_variant, missense_variant
rs368646400 likely-benign, Distal Renal Tubular Acidosis, Recessive 138,798,050(+) G/A 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs373396667 uncertain-significance, Distal Renal Tubular Acidosis, Recessive 138,798,161(+) C/A/T coding_sequence_variant, synonymous_variant
rs746508351 uncertain-significance, Distal Renal Tubular Acidosis, Recessive 138,798,119(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM213 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv3615199 CNV gain 21293372
esv3615200 CNV gain 21293372
nsv1030956 CNV gain 25217958
nsv516706 CNV loss 19592680
nsv831154 CNV gain 17160897

Variation tolerance for TMEM213 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM213 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM213

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM213 Gene

Disorders for TMEM213 Gene

Additional Disease Information for TMEM213

No disorders were found for TMEM213 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM213 Gene

Publications for TMEM213 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56

Products for TMEM213 Gene

  • Biorbyt antibodies for TMEM213

Sources for TMEM213 Gene