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Aliases for TMEM212 Gene

Aliases for TMEM212 Gene

  • Transmembrane Protein 212 2 3 5

External Ids for TMEM212 Gene

Previous GeneCards Identifiers for TMEM212 Gene

  • GC03P173044
  • GC03P171561
  • GC03P168931

Summaries for TMEM212 Gene

GeneCards Summary for TMEM212 Gene

TMEM212 (Transmembrane Protein 212) is a Protein Coding gene.

Additional gene information for TMEM212 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM212 Gene

Genomics for TMEM212 Gene

GeneHancer (GH) Regulatory Elements for TMEM212 Gene

Promoters and enhancers for TMEM212 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I171840 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.2 -1234 3.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 RXRA TMEM212 PLD1
GH03I171804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -34.7 -34662 9.3 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 MEF2D SSRP1 ZNF610 PLD1 FNDC3B TMEM212 RPL22L1 ECT2 TNIK ENSG00000234594
GH03I171872 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16 +31.8 31791 5.1 PKNOX1 FOXA2 ZNF48 FOS ATF7 RUNX3 RXRA JUNB SMARCA4 RCOR2 TMEM212 FNDC3B TMEM212-IT1 TMEM212-AS1
GH03I171767 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.6 -73.0 -73033 5 RB1 RAD21 RFX5 YY1 NCOA2 ZSCAN5C SCRT2 ZNF143 IKZF2 DEK PLD1 TMEM212 FNDC3B ENSG00000234594
GH03I171878 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +35.7 35723 1.4 SOX13 PKNOX1 MAX ZNF644 RAD21 YY1 SCRT2 ZNF143 NR2F6 ATF7 TMEM212 FNDC3B TMEM212-IT1 TMEM212-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM212 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM212 Gene

Genomic Locations for TMEM212 Gene
chr3:171,843,349-171,938,715
(GRCh38/hg38)
Size:
95,367 bases
Orientation:
Plus strand
chr3:171,561,139-171,656,505
(GRCh37/hg19)

Genomic View for TMEM212 Gene

Genes around TMEM212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM212 Gene

Proteins for TMEM212 Gene

  • Protein details for TMEM212 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NML5-TM212_HUMAN
    Recommended name:
    Transmembrane protein 212
    Protein Accession:
    A6NML5

    Protein attributes for TMEM212 Gene

    Size:
    194 amino acids
    Molecular mass:
    21425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM212 Gene

Post-translational modifications for TMEM212 Gene

No Post-translational modifications

Other Protein References for TMEM212 Gene

No data available for DME Specific Peptides for TMEM212 Gene

Domains & Families for TMEM212 Gene

Gene Families for TMEM212 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM212 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM212 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM212: view

No data available for UniProtKB/Swiss-Prot for TMEM212 Gene

Function for TMEM212 Gene

Phenotypes From GWAS Catalog for TMEM212 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM212 Gene

Localization for TMEM212 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM212 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM212 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM212: view

Pathways & Interactions for TMEM212 Gene

SuperPathways for TMEM212 Gene

No Data Available

Interacting Proteins for TMEM212 Gene

Selected Interacting proteins: A6NML5-TM212_HUMAN for TMEM212 Gene via IID

Symbol External ID(s) Details
PTH1R

Gene Ontology (GO) - Biological Process for TMEM212 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM212 Gene

Drugs & Compounds for TMEM212 Gene

No Compound Related Data Available

Transcripts for TMEM212 Gene

mRNA/cDNA for TMEM212 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM212 Gene

Transmembrane protein 212:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM212 Gene

No ASD Table

Relevant External Links for TMEM212 Gene

GeneLoc Exon Structure for
TMEM212
ECgene alternative splicing isoforms for
TMEM212

Expression for TMEM212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM212 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM212 Gene

This gene is overexpressed in Fallopian Tube (x23.9), Lung (x10.7), and Cervix - Endocervix (x7.2).

Protein differential expression in normal tissues from HIPED for TMEM212 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM212 Gene



Protein tissue co-expression partners for TMEM212 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM212 Gene:

TMEM212

SOURCE GeneReport for Unigene cluster for TMEM212 Gene:

Hs.642307

Evidence on tissue expression from TISSUES for TMEM212 Gene

  • Nervous system(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TMEM212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM212 Gene

Orthologs for TMEM212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM212 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM212 33 34
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia TMEM212 33 34
  • 84.88 (n)
dog
(Canis familiaris)
Mammalia TMEM212 33 34
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Tmem212 33 16 34
  • 80.29 (n)
rat
(Rattus norvegicus)
Mammalia Tmem212 33
  • 79.93 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM212 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM212 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem212 33
  • 62.11 (n)
Species where no ortholog for TMEM212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM212 Gene

ENSEMBL:
Gene Tree for TMEM212 (if available)
TreeFam:
Gene Tree for TMEM212 (if available)

Paralogs for TMEM212 Gene

No data available for Paralogs for TMEM212 Gene

Variants for TMEM212 Gene

Sequence variations from dbSNP and Humsavar for TMEM212 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000143828 -- 171,847,927(+) T/C intron_variant
rs1000253748 -- 171,844,978(+) G/A intron_variant
rs1000306591 -- 171,859,196(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000533364 -- 171,852,929(+) G/A intron_variant
rs1000790234 -- 171,847,441(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM212 Gene

Variant ID Type Subtype PubMed ID
esv2672519 CNV deletion 23128226
esv3598652 CNV loss 21293372
esv3598653 CNV loss 21293372
nsv7356 OTHER inversion 18451855

Variation tolerance for TMEM212 Gene

Gene Damage Index Score: 0.46; 10.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM212 Gene

Disorders for TMEM212 Gene

Additional Disease Information for TMEM212

No disorders were found for TMEM212 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM212 Gene

Publications for TMEM212 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach. (PMID: 22828495) Brown AA … Andreassen OA (Translational psychiatry 2012) 3 58
  4. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PMID: 22566498) Turner ST … Boerwinkle E (Hypertension (Dallas, Tex. : 1979) 2012) 3 58
  5. Genome-wide association of BMI in African Americans. (PMID: 21701570) Ng MC … Bowden DW (Obesity (Silver Spring, Md.) 2012) 3 58

Products for TMEM212 Gene

Sources for TMEM212 Gene

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