Aliases for TMEM211 Gene

Aliases for TMEM211 Gene

  • Transmembrane Protein 211 2 3 4 5
  • BA9F11.1 3

External Ids for TMEM211 Gene

Previous GeneCards Identifiers for TMEM211 Gene

  • GC22M023661
  • GC22M025331
  • GC22M008279
  • GC22M025025
  • GC22M025045
  • GC22M026641
  • GC22M026841
  • GC22M025312
  • GC22M025454
  • GC22M025635
  • GC22M025821
  • GC22M026007
  • GC22M026186
  • GC22M026366
  • GC22M026547

Summaries for TMEM211 Gene

GeneCards Summary for TMEM211 Gene

TMEM211 (Transmembrane Protein 211) is a Protein Coding gene. An important paralog of this gene is LHFPL3.

Additional gene information for TMEM211 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM211 Gene

Genomics for TMEM211 Gene

GeneHancer (GH) Regulatory Elements for TMEM211 Gene

Promoters and enhancers for TMEM211 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J024947 Enhancer 0.6 Ensembl ENCODE dbSUPER 750.6 -1.6 -1606 1 SP1 TMEM211 KIAA1671
GH22J024946 Enhancer 0.4 Ensembl dbSUPER 750.6 -0.1 -106 0.4 IKZF1 TMEM211 BCRP3 KIAA1671
GH22J025067 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -122.6 -122563 4.4 MLLT1 ZNF687 PRDM1 ZBTB33 IKZF1 PKNOX1 ZIC2 IKZF2 ZSCAN5C DPF2 KIAA1671-AS1 TMEM211 KIAA1671 CRYBB2 ENSG00000236641 ENSG00000279110 HSALNG0134541
GH22J024962 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -20.1 -20106 8.4 RBPJ NR2F6 HLF RAD21 MNT SP1 PPARG ZIC2 POLR2A RXRA TMEM211 piR-57133-386 KIAA1671
GH22J025074 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -131.8 -131805 7.8 CTCF L3MBTL2 MAX RAD21 ZNF384 TFE3 MLLT1 ZNF687 PPARG REST KIAA1671-AS1 TMEM211 KIAA1671 CRYBB2 ENSG00000279110 HSALNG0134541
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM211 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM211 gene promoter:
  • AREB6
  • c-Ets-1
  • C/EBPalpha
  • COMP1
  • CREB
  • E47
  • Elk-1
  • ER-alpha
  • HNF-1
  • HNF-1A

Genomic Locations for TMEM211 Gene

Genomic Locations for TMEM211 Gene
chr22:24,934,773-24,946,695
(GRCh38/hg38)
Size:
11,923 bases
Orientation:
Minus strand
chr22:25,331,077-25,342,662
(GRCh37/hg19)
Size:
11,586 bases
Orientation:
Minus strand

Genomic View for TMEM211 Gene

Genes around TMEM211 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM211 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM211 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM211 Gene

Proteins for TMEM211 Gene

  • Protein details for TMEM211 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICI0-TM211_HUMAN
    Recommended name:
    Transmembrane protein 211
    Protein Accession:
    Q6ICI0

    Protein attributes for TMEM211 Gene

    Size:
    200 amino acids
    Molecular mass:
    21740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI30648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI30650.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG30274.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TMEM211 Gene

Post-translational modifications for TMEM211 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM211 Gene

No data available for DME Specific Peptides for TMEM211 Gene

Domains & Families for TMEM211 Gene

Gene Families for TMEM211 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM211 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM211 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 211 (TM211_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ICI0

UniProtKB/Swiss-Prot:

TM211_HUMAN :
  • Belongs to the TMEM211 family.
Family:
  • Belongs to the TMEM211 family.
genes like me logo Genes that share domains with TMEM211: view

Function for TMEM211 Gene

Phenotypes From GWAS Catalog for TMEM211 Gene

Phenotypes for TMEM211 Gene

genes like me logo Genes that share phenotypes with TMEM211: view

Animal Models for TMEM211 Gene

MGI Knock Outs for TMEM211:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM211

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM211 Gene

Localization for TMEM211 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM211 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM211 gene
Compartment Confidence
plasma membrane 3
extracellular 0

Gene Ontology (GO) - Cellular Components for TMEM211 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM211: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM211 Gene

Pathways & Interactions for TMEM211 Gene

PathCards logo

SuperPathways for TMEM211 Gene

No Data Available

Interacting Proteins for TMEM211 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000385494 for TMEM211 Gene via STRING

Symbol External ID(s) Details
PCDHB1

Gene Ontology (GO) - Biological Process for TMEM211 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM211 Gene

Drugs & Compounds for TMEM211 Gene

No Compound Related Data Available

Transcripts for TMEM211 Gene

mRNA/cDNA for TMEM211 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM211

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM211 Gene

No ASD Table

Relevant External Links for TMEM211 Gene

GeneLoc Exon Structure for
TMEM211
ECgene alternative splicing isoforms for
TMEM211

Expression for TMEM211 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM211 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM211 Gene

This gene is overexpressed in Minor Salivary Gland (x15.5), Skin - Not Sun Exposed (Suprapubic) (x6.6), Stomach (x5.3), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM211 Gene

This gene is overexpressed in Milk (44.8) and Adipocyte (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM211 Gene



Protein tissue co-expression partners for TMEM211 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM211 Gene:

TMEM211

SOURCE GeneReport for Unigene cluster for TMEM211 Gene:

Hs.329040

Evidence on tissue expression from TISSUES for TMEM211 Gene

  • Lung(2.1)
genes like me logo Genes that share expression patterns with TMEM211: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM211 Gene

Orthologs for TMEM211 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM211 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM211 33 32
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM211 33 32
  • 81.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM211 33 32
  • 81.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem211 32
  • 71.51 (n)
mouse
(Mus musculus)
Mammalia Tmem211 17 33 32
  • 69.11 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM211 33
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem211 32
  • 51.33 (n)
Species where no ortholog for TMEM211 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM211 Gene

ENSEMBL:
Gene Tree for TMEM211 (if available)
TreeFam:
Gene Tree for TMEM211 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM211: view image

Paralogs for TMEM211 Gene

Paralogs for TMEM211 Gene

genes like me logo Genes that share paralogs with TMEM211: view

Variants for TMEM211 Gene

Sequence variations from dbSNP and Humsavar for TMEM211 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000121876 -- 24,945,508(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000307441 -- 24,943,647(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000475775 -- 24,934,846(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000526259 -- 24,934,520(-) C/T downstream_transcript_variant
rs1000700655 -- 24,939,538(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM211 Gene

Variant ID Type Subtype PubMed ID
esv3647445 CNV gain 21293372
nsv1056865 CNV gain 25217958
nsv1065877 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv3580 CNV deletion 18451855
nsv7350 OTHER inversion 18451855
nsv834161 CNV gain 17160897

Variation tolerance for TMEM211 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM211 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM211

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM211 Gene

Disorders for TMEM211 Gene

Additional Disease Information for TMEM211

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM211 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM211 Gene

Publications for TMEM211 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 56
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for TMEM211 Gene

Sources for TMEM211 Gene