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Aliases for TMEM208 Gene

Aliases for TMEM208 Gene

  • Transmembrane Protein 208 2 3 5
  • HSPC171 3

External Ids for TMEM208 Gene

Previous GeneCards Identifiers for TMEM208 Gene

  • GC16P065819
  • GC16P053134

Summaries for TMEM208 Gene

Entrez Gene Summary for TMEM208 Gene

  • This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM208 Gene

TMEM208 (Transmembrane Protein 208) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM208 Gene

  • May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

Additional gene information for TMEM208 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM208 Gene

Genomics for TMEM208 Gene

GeneHancer (GH) Regulatory Elements for TMEM208 Gene

Promoters and enhancers for TMEM208 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067226 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.1 146 2.2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 LRRC29 TMEM208 LOC105369155 EDC4 CENPT NFATC3 KIAA0895L DPEP2 LRRC36 SLC9A5
GH16I067228 Enhancer 0.4 ENCODE 550.8 +1.6 1610 0.2 POLR2A SUPT5H LOC105369155 LRRC29 TMEM208 SLC9A5
GH16I067225 Enhancer 0.4 ENCODE 550.8 -1.4 -1350 0.2 MAFG NFE2 NFE2L2 LOC105369155 LRRC29 TMEM208 ELMO3 GC16M067211
GH16I067413 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +188.0 187977 4 HDGF FOXA2 ARID4B SIN3A ZNF48 ZNF121 ZNF213 ZNF207 ZNF143 KLF13 ZDHHC1 PRMT7 ATP6V0D1 LRRC36 FHOD1 PLEKHG4 TMEM208 LRRC29 HSD11B2 DPEP2
GH16I067718 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +492.3 492283 2.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GFOD2 RANBP10 TSNAXIP1 ACD PARD6A TMEM208 EDC4 DUS2 PIR36768
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM208 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM208 gene promoter:

Genomic Locations for TMEM208 Gene

Genomic Locations for TMEM208 Gene
2,177 bases
Plus strand

Genomic View for TMEM208 Gene

Genes around TMEM208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM208 Gene

Proteins for TMEM208 Gene

  • Protein details for TMEM208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 208
    Protein Accession:
    Secondary Accessions:
    • Q05CT0
    • Q96D25
    • Q9NZZ7

    Protein attributes for TMEM208 Gene

    173 amino acids
    Molecular mass:
    19642 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM208 Gene


neXtProt entry for TMEM208 Gene

Post-translational modifications for TMEM208 Gene

No Post-translational modifications

Other Protein References for TMEM208 Gene

No data available for DME Specific Peptides for TMEM208 Gene

Domains & Families for TMEM208 Gene

Gene Families for TMEM208 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM208 Gene


Suggested Antigen Peptide Sequences for TMEM208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM208 family.
  • Belongs to the TMEM208 family.
genes like me logo Genes that share domains with TMEM208: view

Function for TMEM208 Gene

Molecular function for TMEM208 Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
genes like me logo Genes that share phenotypes with TMEM208: view

Animal Model Products

miRNA for TMEM208 Gene

miRTarBase miRNAs that target TMEM208

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM208 Gene

Localization for TMEM208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM208 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM208 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM208 Gene

Pathways & Interactions for TMEM208 Gene

SuperPathways for TMEM208 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006624 vacuolar protein processing IBA --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM208 Gene

Drugs & Compounds for TMEM208 Gene

No Compound Related Data Available

Transcripts for TMEM208 Gene

Unigene Clusters for TMEM208 Gene

Transmembrane protein 208:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for TMEM208 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM208 Gene

This gene is overexpressed in Liver (36.8), Placenta (12.2), and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM208 Gene

Protein tissue co-expression partners for TMEM208 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM208 Gene:


SOURCE GeneReport for Unigene cluster for TMEM208 Gene:


Evidence on tissue expression from TISSUES for TMEM208 Gene

  • Skin(4.2)
  • Blood(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TMEM208: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM208 Gene

Orthologs for TMEM208 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM208 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM208 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia TMEM208 33 34
  • 95.95 (n)
(Bos Taurus)
Mammalia TMEM208 33 34
  • 91.77 (n)
(Mus musculus)
Mammalia Tmem208 33 16 34
  • 90.51 (n)
(Rattus norvegicus)
Mammalia Tmem208 33
  • 89.66 (n)
(Monodelphis domestica)
Mammalia TMEM208 34
  • 51 (a)
(Gallus gallus)
Aves TMEM208 33
  • 74.47 (n)
(Anolis carolinensis)
Reptilia TMEM208 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem208 33
  • 66.88 (n)
Str.15884 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16797 33
(Danio rerio)
Actinopterygii TMEM208 34
  • 71 (a)
zgc:77041 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8320 33 34
  • 53.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003614 33
  • 48.12 (n)
(Caenorhabditis elegans)
Secernentea R05D11.5 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4985 34
  • 38 (a)
Species where no ortholog for TMEM208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM208 Gene

Gene Tree for TMEM208 (if available)
Gene Tree for TMEM208 (if available)

Paralogs for TMEM208 Gene

No data available for Paralogs for TMEM208 Gene

Variants for TMEM208 Gene

Sequence variations from dbSNP and Humsavar for TMEM208 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001202273 -- 67,227,536(+) C/G intron_variant
rs1002357307 -- 67,228,170(+) C/T intron_variant
rs1002839456 -- 67,227,932(+) G/A/T splice_donor_variant
rs1003099010 -- 67,226,903(+) C/A upstream_transcript_variant
rs1003123024 -- 67,227,985(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM208 Gene

Variant ID Type Subtype PubMed ID
nsv952044 CNV deletion 24416366
nsv827707 CNV loss 20364138
nsv572905 CNV loss 21841781
nsv524492 CNV loss 19592680
nsv524363 CNV loss 19592680
nsv522852 CNV gain 19592680
nsv471092 CNV gain 18288195
nsv457513 CNV loss 19166990

Variation tolerance for TMEM208 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM208 Gene

Disorders for TMEM208 Gene

Additional Disease Information for TMEM208

No disorders were found for TMEM208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM208 Gene

Publications for TMEM208 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. (PMID: 23691174) Zhao Y … Chen Y (PloS one 2013) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H … Arnesen T (Cell reports 2015) 4 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TMEM208 Gene

Sources for TMEM208 Gene

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