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Aliases for TMEM206 Gene

Aliases for TMEM206 Gene

  • Transmembrane Protein 206 2 3 5
  • C1orf75 3 4
  • Chromosome 1 Open Reading Frame 75 2

External Ids for TMEM206 Gene

Previous HGNC Symbols for TMEM206 Gene

  • C1orf75

Previous GeneCards Identifiers for TMEM206 Gene

  • GC01M210605
  • GC01M212537
  • GC01M183214

Summaries for TMEM206 Gene

GeneCards Summary for TMEM206 Gene

TMEM206 (Transmembrane Protein 206) is a Protein Coding gene.

Additional gene information for TMEM206 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM206 Gene

Genomics for TMEM206 Gene

GeneHancer (GH) Regulatory Elements for TMEM206 Gene

Promoters and enhancers for TMEM206 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I212413 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 576.3 +0.4 427 2.4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A IRF4 SLC30A9 POLR2B ZNF766 TMEM206 LOC101929541 PPP2R5A PIR60492
GH01I212283 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.3 +129.6 129572 4.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LOC101929541 PPP2R5A TMEM206 INTS7 ENSG00000230063
GH01I212430 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.3 -16.7 -16665 4.2 ARNT SIN3A YBX1 POLR2B ZNF766 ZNF143 SP3 SP5 REST SMARCB1 NENF LOC105372906 LOC101929541 TMEM206 PPP2R5A DTL INTS7 ENSG00000212187 BATF3
GH01I212455 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.1 -40.7 -40664 1.4 SMAD1 RB1 ZNF2 THRB ZNF48 RAD21 RFX5 ZNF121 ARID2 ZNF143 TMEM206 ATF3 ENSG00000212187 BATF3 LOC105372907 NENF
GH01I212234 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.2 +178.6 178582 5.6 HDGF SMAD1 ATF1 ARNT YY1 TCF12 ZNF766 CBX5 ARID2 ATF7 LOC101929541 TMEM206 RCOR3 RPL21P28 GC01P212241 GC01M212205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM206 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM206 gene promoter:

Genomic Locations for TMEM206 Gene

Genomic Locations for TMEM206 Gene
chr1:212,363,931-212,415,508
(GRCh38/hg38)
Size:
51,578 bases
Orientation:
Minus strand
chr1:212,537,273-212,588,267
(GRCh37/hg19)

Genomic View for TMEM206 Gene

Genes around TMEM206 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM206 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM206 Gene

Proteins for TMEM206 Gene

  • Protein details for TMEM206 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H813-TM206_HUMAN
    Recommended name:
    Transmembrane protein 206
    Protein Accession:
    Q9H813
    Secondary Accessions:
    • B7Z4D6
    • Q6IA87
    • Q9NV85

    Protein attributes for TMEM206 Gene

    Size:
    350 amino acids
    Molecular mass:
    40043 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM206 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM206 Gene

Post-translational modifications for TMEM206 Gene

  • Ubiquitination at isoforms=2166
  • Glycosylation at isoforms=2148, posLast=155155, and posLast=162162
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM206 Gene

Domains & Families for TMEM206 Gene

Gene Families for TMEM206 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM206 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM206 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H813

UniProtKB/Swiss-Prot:

TM206_HUMAN :
  • Belongs to the TMEM206 family.
Family:
  • Belongs to the TMEM206 family.
genes like me logo Genes that share domains with TMEM206: view

Function for TMEM206 Gene

Phenotypes From GWAS Catalog for TMEM206 Gene

Phenotypes for TMEM206 Gene

GenomeRNAi human phenotypes for TMEM206:
genes like me logo Genes that share phenotypes with TMEM206: view

Animal Model Products

CRISPR Products

miRNA for TMEM206 Gene

miRTarBase miRNAs that target TMEM206

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM206 Gene

Localization for TMEM206 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM206 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM206 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface HDA 19581412
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM206: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM206 Gene

Pathways & Interactions for TMEM206 Gene

SuperPathways for TMEM206 Gene

No Data Available

Interacting Proteins for TMEM206 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000438863%0d%0a9606.ENSP00000218075%0d%0a
Selected Interacting proteins: Q9H813-TM206_HUMAN ENSP00000438863 for TMEM206 Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM206 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM206 Gene

Drugs & Compounds for TMEM206 Gene

No Compound Related Data Available

Transcripts for TMEM206 Gene

Unigene Clusters for TMEM206 Gene

Transmembrane protein 206:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM206 Gene

No ASD Table

Relevant External Links for TMEM206 Gene

GeneLoc Exon Structure for
TMEM206
ECgene alternative splicing isoforms for
TMEM206

Expression for TMEM206 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM206 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM206 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.4) and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for TMEM206 Gene

This gene is overexpressed in Testis (42.2) and Spinal cord (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM206 Gene



Protein tissue co-expression partners for TMEM206 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM206 Gene:

TMEM206

SOURCE GeneReport for Unigene cluster for TMEM206 Gene:

Hs.445386

Evidence on tissue expression from TISSUES for TMEM206 Gene

  • Nervous system(4.5)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TMEM206: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM206 Gene

Orthologs for TMEM206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM206 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM206 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TMEM206 33 34
  • 92.67 (n)
cow
(Bos Taurus)
Mammalia TMEM206 33 34
  • 90.1 (n)
rat
(Rattus norvegicus)
Mammalia Tmem206 33
  • 87.05 (n)
mouse
(Mus musculus)
Mammalia Tmem206 33 16 34
  • 86.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM206 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM206 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM206 33 34
  • 71.54 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM206 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem206 33
  • 69.16 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem206 33 34
  • 64.28 (n)
zgc63579 33
Species where no ortholog for TMEM206 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM206 Gene

ENSEMBL:
Gene Tree for TMEM206 (if available)
TreeFam:
Gene Tree for TMEM206 (if available)

Paralogs for TMEM206 Gene

No data available for Paralogs for TMEM206 Gene

Variants for TMEM206 Gene

Sequence variations from dbSNP and Humsavar for TMEM206 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1034429230 breast cancer sample 212,365,260(-) C/G 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000023946 -- 212,384,738(-) T/C intron_variant
rs1000120471 -- 212,390,786(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000257027 -- 212,411,620(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000305373 -- 212,365,020(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM206 Gene

Variant ID Type Subtype PubMed ID
esv3415613 CNV duplication 20981092
esv3418305 CNV duplication 20981092
esv3578412 CNV loss 25503493
esv6419 CNV gain 19470904
nsv549139 CNV gain 21841781

Variation tolerance for TMEM206 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM206 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM206

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM206 Gene

Disorders for TMEM206 Gene

Additional Disease Information for TMEM206

No disorders were found for TMEM206 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM206 Gene

Publications for TMEM206 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM206 Gene

Sources for TMEM206 Gene

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