Aliases for TMEM205 Gene
External Ids for TMEM205 Gene
- HGNC: 29631
- Entrez Gene: 374882
- Ensembl: ENSG00000105518
- OMIM: 613771
- UniProtKB: Q6UW68
Previous GeneCards Identifiers for TMEM205 Gene
- GC19M011316
- GC19M011453
- GC19M011029
Summaries for TMEM205 Gene
GeneCards Summary for TMEM205 Gene
TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.
UniProtKB/Swiss-Prot for TMEM205 Gene
-
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Additional gene information for TMEM205 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene
Genomics for TMEM205 Gene
GeneHancer (GH) Regulatory Elements for TMEM205 Gene
Promoters and enhancers for TMEM205 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMEM205 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TMEM205 gene promoter:
-
- STAT3
- E2F
- c-Ets-1
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Max
Regulatory Element Products
Genomic Locations for TMEM205 Gene
Genomic Locations for TMEM205 Gene
- chr19:11,342,776-11,346,518
- (GRCh38/hg38)
- Size:
- 3,743 bases
- Orientation:
- Minus strand
- chr19:11,453,452-11,457,194
- (GRCh37/hg19)
- Size:
- 3,743 bases
- Orientation:
- Minus strand
Genomic View for TMEM205 Gene
Genes around TMEM205 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
- 19p13.2 by Ensembl
TMEM205 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM205 Gene
Proteins for TMEM205 Gene
-
Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UW68-TM205_HUMAN
- Recommended name:
- Transmembrane protein 205
- Protein Accession:
- Q6UW68
Protein attributes for TMEM205 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 21198 Da
- Quaternary structure:
- No Data Available
Protein Expression for TMEM205 Gene
Post-translational modifications for TMEM205 Gene
Other Protein References for TMEM205 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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-
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Assay Products
No data available for DME Specific Peptides for TMEM205 Gene
Domains & Families for TMEM205 Gene
Gene Families for TMEM205 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Suggested Antigen Peptide Sequences for TMEM205 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UW68- Family:
-
- Belongs to the TMEM205 family.
Function for TMEM205 Gene
Molecular function for TMEM205 Gene
- UniProtKB/Swiss-Prot Function:
- In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Phenotypes From GWAS Catalog for TMEM205 Gene
Phenotypes for TMEM205 Gene
Animal Model Products
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-
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miRNA for TMEM205 Gene
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene
Localization for TMEM205 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene
- Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endosome | 1 |
- Endoplasmic reticulum (2)
- Nuclear membrane (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | -- |
Pathways & Interactions for TMEM205 Gene
No Data Available
Interacting Proteins for TMEM205 Gene
GPS-Prot Interaction Network for TMEM205
No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene
Transcripts for TMEM205 Gene
mRNA/cDNA for TMEM205 Gene
- (10) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (424) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000586218 593 bps (uc060tqg.1)
- ENST00000593256 792 bps (uc002mrb.3)
- ENST00000354882 1034 bps (uc002mqz.3)
- ENST00000585722 1147 bps (uc060tqh.1)
- ENST00000586590 677 bps (uc060tqi.1)
Unigene Clusters for TMEM205 Gene
- Transmembrane protein 205:
- Representative Sequences:
CRISPR Products
-
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||
| SP8: |
Expression for TMEM205 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Nasal epithelium (28.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM205 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TMEM205 Gene:
TMEM205SOURCE GeneReport for Unigene cluster for TMEM205 Gene:
Hs.8036mRNA Expression by UniProt/SwissProt for TMEM205 Gene:
Q6UW68-TM205_HUMAN
Tissue specificity:
Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).
Evidence on tissue expression from TISSUES for TMEM205 Gene
- Liver(4.4)
- Intestine(4.3)
- Pancreas(4.3)
- Nervous system(3.2)
- Adrenal gland(2.2)
Primer Products
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OriGene qPCR primer pairs for TMEM205
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OriGene qPCR primer pairs and template standards for TMEM205
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Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM205 Gene
Orthologs for TMEM205 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM205 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TMEM205 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TMEM205 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tmem205 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tmem205 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM205 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TMEM205 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem205 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem205 34 33 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G62580 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0673100 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TMEM205 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TMEM205 Gene
- ENSEMBL:
- Gene Tree for TMEM205 (if available)
- TreeFam:
- Gene Tree for TMEM205 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM205: view image
Paralogs for TMEM205 Gene
No data available for Paralogs for TMEM205 Gene
Variants for TMEM205 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000270331 | -- | 11,344,732(-) | G/C | intron_variant | |
| rs1001271723 | -- | 11,346,682(-) | G/A | upstream_transcript_variant | |
| rs1002544834 | -- | 11,343,856(-) | C/T | intron_variant | |
| rs1002597718 | -- | 11,343,599(-) | A/G | intron_variant | |
| rs1002668936 | -- | 11,345,023(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.24;
24.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM205 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM205
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM205 Gene
Disorders for TMEM205 Gene
Additional Disease Information for TMEM205
No disorders were found for TMEM205 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene
Publications for TMEM205 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen DW … Gottesman MM (Journal of cellular physiology 2010) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
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Sources for TMEM205 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
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