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Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3 3 5
  • MBC3205 3
  • UNQ501 3

External Ids for TMEM205 Gene

Previous GeneCards Identifiers for TMEM205 Gene

  • GC19M011316
  • GC19M011453
  • GC19M011029

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Additional gene information for TMEM205 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

GeneHancer (GH) Regulatory Elements for TMEM205 Gene

Promoters and enhancers for TMEM205 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.2 -29.8 -29802 6.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMEM205 ENSG00000267277 SWSAP1 PIR61774 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625
GH19J011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.8 772 5 CLOCK FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MEF2D PIR44072 RAB3D PIR37751 TMEM205 CCDC159 ILF3 KRI1 ZNF136 ZNF627 ZNF44
GH19J011379 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.2 -35.8 -35848 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 EPOR KRI1 ILF3 TIMM29 ZNF44 ZNF136 ZNF433 ZNF878 ZNF20 ZNF563
GH19J011369 Enhancer 0.6 ENCODE 12.6 -23.3 -23272 0.1 HDAC1 AFF1 ARID4B MAX NCOA1 SIN3A MIER2 REST ZBTB40 ZNF143 RAB3D TMEM205 CCDC159 TSPAN16 SWSAP1 ENSG00000267277 PLPPR2
GH19J011380 Enhancer 0.5 ENCODE 12.2 -33.1 -33122 0.2 TCF12 HDAC2 TAL1 KLF9 KDM1A CCDC159 TMEM205 RAB3D EPOR PIR61774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM205 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM205 gene promoter:
  • STAT3
  • E2F
  • c-Ets-1
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max

Genomic Locations for TMEM205 Gene

Genomic Locations for TMEM205 Gene
chr19:11,342,776-11,346,518
(GRCh38/hg38)
Size:
3,743 bases
Orientation:
Minus strand
chr19:11,453,452-11,457,194
(GRCh37/hg19)
Size:
3,743 bases
Orientation:
Minus strand

Genomic View for TMEM205 Gene

Genes around TMEM205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW68-TM205_HUMAN
    Recommended name:
    Transmembrane protein 205
    Protein Accession:
    Q6UW68

    Protein attributes for TMEM205 Gene

    Size:
    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains & Families for TMEM205 Gene

Gene Families for TMEM205 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for TMEM205 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM205 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW68

UniProtKB/Swiss-Prot:

TM205_HUMAN :
  • Belongs to the TMEM205 family.
Family:
  • Belongs to the TMEM205 family.
genes like me logo Genes that share domains with TMEM205: view

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function:
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Phenotypes From GWAS Catalog for TMEM205 Gene

genes like me logo Genes that share phenotypes with TMEM205: view

Animal Model Products

CRISPR Products

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 2
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with TMEM205: view

Pathways & Interactions for TMEM205 Gene

SuperPathways for TMEM205 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM205 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene

Drugs & Compounds for TMEM205 Gene

No Compound Related Data Available

Transcripts for TMEM205 Gene

Unigene Clusters for TMEM205 Gene

Transmembrane protein 205:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for
TMEM205
ECgene alternative splicing isoforms for
TMEM205

Expression for TMEM205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM205 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM205 Gene



Protein tissue co-expression partners for TMEM205 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM205 Gene:

TMEM205

SOURCE GeneReport for Unigene cluster for TMEM205 Gene:

Hs.8036

mRNA Expression by UniProt/SwissProt for TMEM205 Gene:

Q6UW68-TM205_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

Evidence on tissue expression from TISSUES for TMEM205 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Pancreas(4.3)
  • Nervous system(3.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with TMEM205: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM205 Gene

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM205 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM205 34 33
  • 89.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM205 34 33
  • 88.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem205 16 34 33
  • 81.48 (n)
rat
(Rattus norvegicus)
Mammalia Tmem205 33
  • 80.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM205 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM205 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem205 33
  • 59.57 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem205 34 33
  • 54.75 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 33
  • 43.35 (n)
rice
(Oryza sativa)
Liliopsida Os11g0673100 33
  • 47.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for TMEM205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

ENSEMBL:
Gene Tree for TMEM205 (if available)
TreeFam:
Gene Tree for TMEM205 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM205: view image

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

Sequence variations from dbSNP and Humsavar for TMEM205 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000270331 -- 11,344,732(-) G/C intron_variant
rs1001271723 -- 11,346,682(-) G/A upstream_transcript_variant
rs1002544834 -- 11,343,856(-) C/T intron_variant
rs1002597718 -- 11,343,599(-) A/G intron_variant
rs1002668936 -- 11,345,023(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv578615 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for TMEM205 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM205 Gene

Disorders for TMEM205 Gene

Additional Disease Information for TMEM205

No disorders were found for TMEM205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen DW … Gottesman MM (Journal of cellular physiology 2010) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM205 Gene

Sources for TMEM205 Gene

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