Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3 4 5
  • MBC3205 2 3
  • UNQ501 2 3
  • TMEM205 5

External Ids for TMEM205 Gene

Previous GeneCards Identifiers for TMEM205 Gene

  • GC19M011316
  • GC19M011453
  • GC19M011029

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene. Diseases associated with TMEM205 include Cataract 34, Multiple Types.

UniProtKB/Swiss-Prot Summary for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM205 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM205 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM205

Top Transcription factor binding sites by QIAGEN in the TMEM205 gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max
  • STAT3

Genomic Locations for TMEM205 Gene

Latest Assembly
4,007 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,491 bases
Minus strand

(GRCh37/hg19 by Ensembl)
3,743 bases
Minus strand

Genomic View for TMEM205 Gene

Genes around TMEM205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 205
    Protein Accession:

    Protein attributes for TMEM205 Gene

    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains & Families for TMEM205 Gene

Gene Families for TMEM205 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM205 Gene


Suggested Antigen Peptide Sequences for TMEM205 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 205 (TM205_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM205 family.
  • Belongs to the TMEM205 family.
genes like me logo Genes that share domains with TMEM205: view

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function:
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Phenotypes From GWAS Catalog for TMEM205 Gene

Gene Ontology (GO) - Molecular Function for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TMEM205: view
genes like me logo Genes that share phenotypes with TMEM205: view

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM205

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane. Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM205: view

Pathways & Interactions for TMEM205 Gene

PathCards logo

SuperPathways for TMEM205 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM205: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene

Drugs & Compounds for TMEM205 Gene

No Compound Related Data Available

Transcripts for TMEM205 Gene

mRNA/cDNA for TMEM205 Gene

12 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM205

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for

Expression for TMEM205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM205 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM205 Gene

Protein tissue co-expression partners for TMEM205 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM205

SOURCE GeneReport for Unigene cluster for TMEM205 Gene:


mRNA Expression by UniProt/SwissProt for TMEM205 Gene:

Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

Evidence on tissue expression from TISSUES for TMEM205 Gene

  • Liver(4.5)
  • Pancreas(4.4)
  • Intestine(4.3)
  • Nervous system(3.2)
  • Adrenal gland(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with TMEM205: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM205 Gene

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM205 30 31
  • 99.65 (n)
(Canis familiaris)
Mammalia TMEM205 30 31
  • 89.77 (n)
(Bos Taurus)
Mammalia TMEM205 30 31
  • 88.95 (n)
(Mus musculus)
Mammalia Tmem205 30 17 31
  • 81.48 (n)
(Rattus norvegicus)
Mammalia Tmem205 30
  • 80.78 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM205 31
  • 59 (a)
(Anolis carolinensis)
Reptilia TMEM205 31
  • 48 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem205 30
  • 59.57 (n)
(Danio rerio)
Actinopterygii tmem205 30 31
  • 54.75 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 30
  • 43.35 (n)
(Oryza sativa)
Liliopsida Os11g0673100 30
  • 47.49 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
Species where no ortholog for TMEM205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

Gene Tree for TMEM205 (if available)
Gene Tree for TMEM205 (if available)
Evolutionary constrained regions (ECRs) for TMEM205: view image

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM205 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv578615 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for TMEM205 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM205 Gene

Disorders for TMEM205 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM205 Gene - From: COP

Disorder Aliases PubMed IDs
cataract 34, multiple types
  • ctrct34
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM205

genes like me logo Genes that share disorders with TMEM205: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen DW … Gottesman MM (Journal of cellular physiology 2010) 3 4
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. (PMID: 31536960) Moutaoufik MT … Babu M (iScience 2019) 3

Products for TMEM205 Gene

Sources for TMEM205 Gene