Aliases for TMEM201 Gene

Aliases for TMEM201 Gene

  • Transmembrane Protein 201 2 3 4 5
  • SAMP1 2 3 4
  • NET5 2 3 4
  • Spindle-Associated Membrane Protein 1 3 4
  • RP13-15M17.2 2 3
  • Ima1 2 3
  • Spindle Associated Membrane Protein 1 2
  • TMEM201 5

External Ids for TMEM201 Gene

Previous GeneCards Identifiers for TMEM201 Gene

  • GC01P009572
  • GC01P008799
  • GC01P009648

Summaries for TMEM201 Gene

GeneCards Summary for TMEM201 Gene

TMEM201 (Transmembrane Protein 201) is a Protein Coding gene. Diseases associated with TMEM201 include Ileitis and Gastroduodenitis. Gene Ontology (GO) annotations related to this gene include actin filament binding and lamin binding.

UniProtKB/Swiss-Prot Summary for TMEM201 Gene

  • Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).
  • [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM201 Gene

Genomics for TMEM201 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM201 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 256 +1.2 1173 4 ZNF207 ZNF600 MYC IKZF1 ZIC2 NONO CTCF ZNF592 SIN3A ZNF341 TMEM201 SLC25A33 HSALNG0000707 PIK3CD
GH01J009555 Enhancer 0.9 Ensembl ENCODE 16.2 -33.3 -33342 1.4 JUND ATF3 YY1 FOXA2 RXRA SAP130 RARA ZNF843 RBM22 PRDM6 TMEM201 piR-34822-002 HSALNG0000677 SLC25A33
GH01J009537 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.3 -49.4 -49356 4.6 SP1 ZNF207 MYC ZNF600 IKZF1 SSRP1 ZNF580 ZNF592 ATF2 POLR2A SLC25A33 TMEM201 piR-34822-002 HSALNG0000677
GH01J009625 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 5.9 +39.9 39918 6 BCLAF1 SP1 ZNF207 ZNF654 MYC ZNF600 IKZF1 ZNF592 ZMYM3 POLR2A PIK3CD HSALNG0000710 LOC105376712 SLC25A33 TMEM201 RF00017-042
GH01J009592 Promoter/Enhancer 1.2 Ensembl ENCODE 5.3 +5.1 5124 3.7 IKZF1 ZIC2 REST SIN3A BHLHE40 MNT KLF9 HCFC1 SP2 SAP130 TMEM201 HSALNG0000707 lnc-CLSTN1-7 PIK3CD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM201 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM201

Top Transcription factor binding sites by QIAGEN in the TMEM201 gene promoter:
  • c-Myb
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • Elk-1
  • HEN1
  • MyoD

Genomic Locations for TMEM201 Gene

Latest Assembly
chr1:9,588,843-9,614,877
(GRCh38/hg38)
Size:
26,035 bases
Orientation:
Plus strand

Previous Assembly
chr1:9,648,969-9,674,935
(GRCh37/hg19 by Entrez Gene)
Size:
25,967 bases
Orientation:
Plus strand

chr1:9,648,932-9,674,935
(GRCh37/hg19 by Ensembl)
Size:
26,004 bases
Orientation:
Plus strand

Genomic View for TMEM201 Gene

Genes around TMEM201 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM201 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM201 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM201 Gene

Proteins for TMEM201 Gene

  • Protein details for TMEM201 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SNT2-TM201_HUMAN
    Recommended name:
    Transmembrane protein 201
    Protein Accession:
    Q5SNT2
    Secondary Accessions:
    • B9EH90
    • Q5SNT3

    Protein attributes for TMEM201 Gene

    Size:
    666 amino acids
    Molecular mass:
    72236 Da
    Quaternary structure:
    • Isoform 2 interacts with EMD (PubMed:21610090). Interacts with SUN2 and LMNA (By similarity). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP.

    Alternative splice isoforms for TMEM201 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM201 Gene

Post-translational modifications for TMEM201 Gene

  • Ubiquitination at Lys133 and Lys192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM201 Gene

Domains & Families for TMEM201 Gene

Gene Families for TMEM201 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM201 Gene

Suggested Antigen Peptide Sequences for TMEM201 Gene

GenScript: Design optimal peptide antigens:
  • Novel protein (Q5SNT1_HUMAN)
  • Spindle-associated membrane protein 1 (TM201_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SNT2

UniProtKB/Swiss-Prot:

TM201_HUMAN :
  • Belongs to the TMEM201 family.
Family:
  • Belongs to the TMEM201 family.
genes like me logo Genes that share domains with TMEM201: view

Function for TMEM201 Gene

Molecular function for TMEM201 Gene

UniProtKB/Swiss-Prot Function:
Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).

Phenotypes From GWAS Catalog for TMEM201 Gene

Gene Ontology (GO) - Molecular Function for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0005521 lamin binding IBA 21873635
GO:0051015 actin filament binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with TMEM201: view
genes like me logo Genes that share phenotypes with TMEM201: view

Animal Models for research

  • Taconic Biosciences Mouse Models for TMEM201

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM201

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM201 Gene

Localization for TMEM201 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM201 Gene

[Isoform 2]: Nucleus inner membrane. Multi-pass membrane protein. Cytoplasm, cytoskeleton, spindle pole. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269 PubMed:19494128, ECO:0000269 PubMed:21610090}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM201 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 4
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA --
GO:0005637 nuclear inner membrane IEA --
GO:0005639 integral component of nuclear inner membrane IEA --
genes like me logo Genes that share ontologies with TMEM201: view

Pathways & Interactions for TMEM201 Gene

PathCards logo

SuperPathways for TMEM201 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP --
GO:0007097 nuclear migration IEA --
GO:0010761 fibroblast migration IEA --
GO:0030473 nuclear migration along microtubule IBA 21873635
GO:0051642 centrosome localization IMP --
genes like me logo Genes that share ontologies with TMEM201: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM201 Gene

Drugs & Compounds for TMEM201 Gene

No Compound Related Data Available

Transcripts for TMEM201 Gene

mRNA/cDNA for TMEM201 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM201

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM201 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for TMEM201 Gene

GeneLoc Exon Structure for
TMEM201

Expression for TMEM201 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM201 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM201 Gene

This gene is overexpressed in Muscle - Skeletal (x6.0).

Protein differential expression in normal tissues from HIPED for TMEM201 Gene

This gene is overexpressed in Nasal epithelium (24.5), Serum (12.6), Retina (8.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM201 Gene



Protein tissue co-expression partners for TMEM201 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM201

SOURCE GeneReport for Unigene cluster for TMEM201 Gene:

Hs.632365

Evidence on tissue expression from TISSUES for TMEM201 Gene

  • Eye(4.3)
  • Nervous system(2.6)
  • Intestine(2.3)
  • Liver(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TMEM201: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM201 Gene

Orthologs for TMEM201 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM201 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM201 29
  • 95.94 (n)
Cow
(Bos Taurus)
Mammalia TMEM201 29 30
  • 88.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM201 29 30
  • 84.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem201 29 16 30
  • 83.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem201 29
  • 82.55 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM201 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM201 30
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM201 30
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM201 30
  • 62 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tmem201 29 30
  • 58.53 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7744 30
  • 17 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea samp-1 30
  • 19 (a)
OneToOne
Species where no ortholog for TMEM201 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TMEM201 Gene

ENSEMBL:
Gene Tree for TMEM201 (if available)
TreeFam:
Gene Tree for TMEM201 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM201: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM201

Paralogs for TMEM201 Gene

No data available for Paralogs for TMEM201 Gene

Variants for TMEM201 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM201 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs114072438 Benign: not provided 9,610,680(+) C/A
NM_001130924.3(TMEM201):c.1640C>A (p.Pro547His)
MISSENSE
rs116228362 Benign: not provided 9,596,879(+) G/A
NM_001130924.3(TMEM201):c.255G>A (p.Pro85=)
SYNONYMOUS
rs11799995 Benign: not provided 9,612,988(+) C/T
NM_001130924.3(TMEM201):c.1906C>T (p.Arg636Cys)
MISSENSE
rs141358122 Benign: not provided 9,598,619(+) C/T
NM_001130924.3(TMEM201):c.600C>T (p.His200=)
SYNONYMOUS
rs141781360 Benign: not provided 9,601,131(+) G/A
NM_001130924.3(TMEM201):c.633G>A (p.Pro211=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM201 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM201 Gene

Variant ID Type Subtype PubMed ID
esv2743619 CNV deletion 23290073
nsv1013224 CNV gain 25217958
nsv1118098 CNV deletion 24896259
nsv2187 CNV insertion 18451855
nsv508847 CNV insertion 20534489
nsv545363 CNV loss 21841781

Variation tolerance for TMEM201 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM201 Gene

Human Gene Mutation Database (HGMD)
TMEM201
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM201
Leiden Open Variation Database (LOVD)
TMEM201

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM201 Gene

Disorders for TMEM201 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TMEM201 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM201

genes like me logo Genes that share disorders with TMEM201: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM201 Gene

Publications for TMEM201 Gene

  1. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. (PMID: 19494128) Buch C … Hallberg E (Journal of cell science 2009) 2 3 4
  2. A transmembrane inner nuclear membrane protein in the mitotic spindle. (PMID: 21327071) Figueroa R … Hallberg E (Nucleus (Austin, Tex.) 2010) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3
  5. FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. (PMID: 31056421) Ceccarelli DF … Sicheri F (Structure (London, England : 1993) 2019) 3

Products for TMEM201 Gene

Sources for TMEM201 Gene