Aliases for TMEM201 Gene

Aliases for TMEM201 Gene

  • Transmembrane Protein 201 2 3 4 5
  • Spindle-Associated Membrane Protein 1 3 4
  • SAMP1 3 4
  • NET5 3 4
  • Spindle Associated Membrane Protein 1 2
  • RP13-15M17.2 3
  • Ima1 3

External Ids for TMEM201 Gene

Previous GeneCards Identifiers for TMEM201 Gene

  • GC01P009572
  • GC01P008799
  • GC01P009648

Summaries for TMEM201 Gene

GeneCards Summary for TMEM201 Gene

TMEM201 (Transmembrane Protein 201) is a Protein Coding gene. Diseases associated with TMEM201 include Ileitis and Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include actin filament binding and lamin binding.

UniProtKB/Swiss-Prot Summary for TMEM201 Gene

  • Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).
  • Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).

Additional gene information for TMEM201 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM201 Gene

Genomics for TMEM201 Gene

GeneHancer (GH) Regulatory Elements for TMEM201 Gene

Promoters and enhancers for TMEM201 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 756 +0.5 548 2.8 CTCF ZBTB6 POLR2A MYC NFYC L3MBTL2 MNT NKRF ELF3 ZFX TMEM201 H6PD PIK3CD-AS2 SLC25A33 MIR34AHG GPR157 lnc-CLSTN1-7
GH01J009555 Enhancer 0.9 Ensembl ENCODE 16.2 -33.4 -33356 1.4 FOXA1 SP1 SP7 ZSCAN21 PPARG KLF14 RXRA PRDM10 RXRB FOXA2 TMEM201 piR-34822-002 SLC25A33
GH01J009537 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.3 -49.4 -49366 4.6 SP1 ZBTB6 FOXA1 MLX RBPJ SMARCE1 POLR2A USF2 NR2F6 ATF1 SLC25A33 SPSB1 H6PD TMEM201 piR-34822-002
GH01J009625 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 5.9 +39.9 39908 6 ZNF24 SP1 ZBTB40 CTCF ZBTB6 RBPJ SMARCE1 HCFC1 MIXL1 RUNX1 PIK3CD LOC105376712 H6PD PIK3CD-AS2 SLC25A33 RERE MIR34AHG GPR157 DFFA TMEM201
GH01J009592 Promoter/Enhancer 1.2 Ensembl ENCODE 5.3 +5.1 5114 3.7 ZBTB40 RUNX1 NFYC MNT ELF3 SP7 KAT8 IKZF1 GLIS2 ZIC2 H6PD PIK3CD-AS2 MIR34AHG GPR157 TMEM201 lnc-CLSTN1-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM201 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM201 gene promoter:
  • c-Myb
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • Elk-1
  • HEN1
  • MyoD

Genomic Locations for TMEM201 Gene

Genomic Locations for TMEM201 Gene
chr1:9,588,853-9,614,877
(GRCh38/hg38)
Size:
26,025 bases
Orientation:
Plus strand
chr1:9,648,932-9,674,935
(GRCh37/hg19)
Size:
26,004 bases
Orientation:
Plus strand

Genomic View for TMEM201 Gene

Genes around TMEM201 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM201 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM201 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM201 Gene

Proteins for TMEM201 Gene

  • Protein details for TMEM201 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SNT2-TM201_HUMAN
    Recommended name:
    Transmembrane protein 201
    Protein Accession:
    Q5SNT2
    Secondary Accessions:
    • B9EH90
    • Q5SNT3

    Protein attributes for TMEM201 Gene

    Size:
    666 amino acids
    Molecular mass:
    72236 Da
    Quaternary structure:
    • Isoform 2 interacts with EMD (PubMed:21610090). Interacts with SUN2 and LMNA (By similarity). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP.

    Alternative splice isoforms for TMEM201 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM201 Gene

Post-translational modifications for TMEM201 Gene

  • Ubiquitination at Lys133 and Lys192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM201 Gene

Domains & Families for TMEM201 Gene

Gene Families for TMEM201 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM201 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM201 Gene

GenScript: Design optimal peptide antigens:
  • Novel protein (Q5SNT1_HUMAN)
  • Spindle-associated membrane protein 1 (TM201_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SNT2

UniProtKB/Swiss-Prot:

TM201_HUMAN :
  • Belongs to the TMEM201 family.
Family:
  • Belongs to the TMEM201 family.
genes like me logo Genes that share domains with TMEM201: view

Function for TMEM201 Gene

Molecular function for TMEM201 Gene

UniProtKB/Swiss-Prot Function:
Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).
UniProtKB/Swiss-Prot Function:
Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).

Phenotypes From GWAS Catalog for TMEM201 Gene

Gene Ontology (GO) - Molecular Function for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005521 lamin binding IBA,IEA 21873635
GO:0051015 actin filament binding IBA,IEA 21873635
genes like me logo Genes that share ontologies with TMEM201: view
genes like me logo Genes that share phenotypes with TMEM201: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM201

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM201 Gene

Localization for TMEM201 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM201 Gene

Isoform 2: Nucleus inner membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, spindle pole. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269 PubMed:19494128, ECO:0000269 PubMed:21610090}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM201 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005639 integral component of nuclear inner membrane IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TMEM201: view

Pathways & Interactions for TMEM201 Gene

PathCards logo

SuperPathways for TMEM201 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007097 nuclear migration IEA --
GO:0010761 fibroblast migration IEA --
GO:0030473 nuclear migration along microtubule IBA 21873635
genes like me logo Genes that share ontologies with TMEM201: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM201 Gene

Drugs & Compounds for TMEM201 Gene

No Compound Related Data Available

Transcripts for TMEM201 Gene

mRNA/cDNA for TMEM201 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM201 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for TMEM201 Gene

GeneLoc Exon Structure for
TMEM201
ECgene alternative splicing isoforms for
TMEM201

Expression for TMEM201 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM201 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM201 Gene

This gene is overexpressed in Muscle - Skeletal (x6.0).

Protein differential expression in normal tissues from HIPED for TMEM201 Gene

This gene is overexpressed in Nasal epithelium (24.5), Serum (12.6), Retina (8.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM201 Gene



Protein tissue co-expression partners for TMEM201 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM201 Gene:

TMEM201

SOURCE GeneReport for Unigene cluster for TMEM201 Gene:

Hs.632365

Evidence on tissue expression from TISSUES for TMEM201 Gene

  • Eye(4.2)
  • Nervous system(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with TMEM201: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM201 Gene

Orthologs for TMEM201 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM201 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM201 32
  • 95.94 (n)
cow
(Bos Taurus)
Mammalia TMEM201 33 32
  • 88.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM201 33 32
  • 84.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem201 17 33 32
  • 83.41 (n)
rat
(Rattus norvegicus)
Mammalia Tmem201 32
  • 82.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM201 33
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM201 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM201 33
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM201 33
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem201 33 32
  • 58.53 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7744 33
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea samp-1 33
  • 19 (a)
OneToOne
Species where no ortholog for TMEM201 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM201 Gene

ENSEMBL:
Gene Tree for TMEM201 (if available)
TreeFam:
Gene Tree for TMEM201 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM201: view image

Paralogs for TMEM201 Gene

No data available for Paralogs for TMEM201 Gene

Variants for TMEM201 Gene

Sequence variations from dbSNP and Humsavar for TMEM201 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000135174 -- 9,606,119(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000199329 -- 9,605,107(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000203256 -- 9,612,361(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000252564 -- 9,612,756(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000313837 -- 9,587,806(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM201 Gene

Variant ID Type Subtype PubMed ID
esv2743619 CNV deletion 23290073
nsv1013224 CNV gain 25217958
nsv1118098 CNV deletion 24896259
nsv2187 CNV insertion 18451855
nsv508847 CNV insertion 20534489
nsv545363 CNV loss 21841781

Variation tolerance for TMEM201 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM201 Gene

Human Gene Mutation Database (HGMD)
TMEM201
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM201

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM201 Gene

Disorders for TMEM201 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM201 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
ileitis
  • crohn's ileitis
emery-dreifuss muscular dystrophy 2, autosomal dominant
  • edmd2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM201

genes like me logo Genes that share disorders with TMEM201: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM201 Gene

Publications for TMEM201 Gene

  1. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. (PMID: 19494128) Buch C … Hallberg E (Journal of cell science 2009) 2 3 4 56
  2. A transmembrane inner nuclear membrane protein in the mitotic spindle. (PMID: 21327071) Figueroa R … Hallberg E (Nucleus (Austin, Tex.) 2010) 2 3 56
  3. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  5. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. (PMID: 29540532) Zuzow N … Bennett EJ (Molecular biology of the cell 2018) 3 56

Products for TMEM201 Gene

Sources for TMEM201 Gene