Aliases for TMEM200B Gene

Aliases for TMEM200B Gene

  • Transmembrane Protein 200B 2 3 4 5
  • TTMB 2 3 4
  • Two Transmembrane Domain-Containing Family Member B 3 4
  • Transmembrane Protein TTMA 3 4
  • Two Transmembrane B 3
  • TMEM200B 5

External Ids for TMEM200B Gene

Previous GeneCards Identifiers for TMEM200B Gene

  • GC01M029318
  • GC01M029445
  • GC01M027698

Summaries for TMEM200B Gene

GeneCards Summary for TMEM200B Gene

TMEM200B (Transmembrane Protein 200B) is a Protein Coding gene. Diseases associated with TMEM200B include Griscelli Syndrome, Type 3. An important paralog of this gene is TMEM200A.

Additional gene information for TMEM200B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM200B Gene

Genomics for TMEM200B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM200B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM200B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM200B

Top Transcription factor binding sites by QIAGEN in the TMEM200B gene promoter:
  • CREB
  • deltaCREB
  • Egr-2
  • HFH-1
  • Pbx1a
  • RORalpha1
  • USF-1
  • USF-1:USF-2
  • USF2

Genomic Locations for TMEM200B Gene

Genomic Locations for TMEM200B Gene
chr1:29,119,425-29,129,138
(GRCh38/hg38)
Size:
9,714 bases
Orientation:
Minus strand
chr1:29,445,937-29,450,447
(GRCh37/hg19)
Size:
4,511 bases
Orientation:
Minus strand

Genomic View for TMEM200B Gene

Genes around TMEM200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM200B Gene

Proteins for TMEM200B Gene

  • Protein details for TMEM200B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YZ2-T200B_HUMAN
    Recommended name:
    Transmembrane protein 200B
    Protein Accession:
    Q69YZ2
    Secondary Accessions:
    • Q6P2G8
    • Q6P2Q5

    Protein attributes for TMEM200B Gene

    Size:
    307 amino acids
    Molecular mass:
    32750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM200B Gene

Post-translational modifications for TMEM200B Gene

  • Glycosylation at Asn88
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM200B Gene

No data available for DME Specific Peptides for TMEM200B Gene

Domains & Families for TMEM200B Gene

Gene Families for TMEM200B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM200B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM200B Gene

GenScript: Design optimal peptide antigens:
  • Two transmembrane domain-containing family member B (T200B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q69YZ2

UniProtKB/Swiss-Prot:

T200B_HUMAN :
  • Belongs to the TMEM200 family.
Family:
  • Belongs to the TMEM200 family.
genes like me logo Genes that share domains with TMEM200B: view

Function for TMEM200B Gene

Phenotypes From GWAS Catalog for TMEM200B Gene

genes like me logo Genes that share phenotypes with TMEM200B: view

Animal Model Products

CRISPR Products

miRNA for TMEM200B Gene

miRTarBase miRNAs that target TMEM200B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM200B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM200B Gene

Localization for TMEM200B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM200B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM200B gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM200B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM200B Gene

Pathways & Interactions for TMEM200B Gene

PathCards logo

SuperPathways for TMEM200B Gene

No Data Available

Interacting Proteins for TMEM200B Gene

Gene Ontology (GO) - Biological Process for TMEM200B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM200B Gene

Drugs & Compounds for TMEM200B Gene

No Compound Related Data Available

Transcripts for TMEM200B Gene

mRNA/cDNA for TMEM200B Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM200B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM200B Gene

No ASD Table

Relevant External Links for TMEM200B Gene

GeneLoc Exon Structure for
TMEM200B

Expression for TMEM200B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM200B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM200B Gene

This gene is overexpressed in Uterus (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM200B

SOURCE GeneReport for Unigene cluster for TMEM200B Gene:

Hs.712722

Evidence on tissue expression from TISSUES for TMEM200B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM200B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM200B Gene

Orthologs for TMEM200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM200B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM200B 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM200B 30 31
  • 92.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM200B 30 31
  • 90.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem200b 30
  • 82.86 (n)
Mouse
(Mus musculus)
Mammalia Tmem200b 30 17 31
  • 82.16 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM200B 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM200B 31
  • 34 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM200B 31
  • 36 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii TMEM200B 31
  • 21 (a)
OneToOne
Species where no ortholog for TMEM200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM200B Gene

ENSEMBL:
Gene Tree for TMEM200B (if available)
TreeFam:
Gene Tree for TMEM200B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM200B: view image

Paralogs for TMEM200B Gene

Paralogs for TMEM200B Gene

genes like me logo Genes that share paralogs with TMEM200B: view

Variants for TMEM200B Gene

Additional dbSNP identifiers (rs#s) for TMEM200B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM200B Gene

Variant ID Type Subtype PubMed ID
nsv509091 CNV insertion 20534489

Variation tolerance for TMEM200B Gene

Gene Damage Index Score: 1.53; 29.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM200B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM200B Gene

Disorders for TMEM200B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM200B Gene - From: DISEASES

Disorder Aliases PubMed IDs
griscelli syndrome, type 3
  • gs3
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMEM200B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM200B Gene

Publications for TMEM200B Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard BS … Muir WJ (Psychiatric genetics 2005) 2 3
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMEM200B Gene

Sources for TMEM200B Gene