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Aliases for TMEM198 Gene

Aliases for TMEM198 Gene

  • Transmembrane Protein 198 2 3 5
  • TMEM198A 3

External Ids for TMEM198 Gene

Previous GeneCards Identifiers for TMEM198 Gene

  • GC02P220117
  • GC02P220408
  • GC02P212261

Summaries for TMEM198 Gene

GeneCards Summary for TMEM198 Gene

TMEM198 (Transmembrane Protein 198) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM198 Gene

  • Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

Additional gene information for TMEM198 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM198 Gene

Genomics for TMEM198 Gene

GeneHancer (GH) Regulatory Elements for TMEM198 Gene

Promoters and enhancers for TMEM198 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I219541 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 526 5.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TMEM198 CHPF ASIC4 OBSL1 INHA ENSG00000268896
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +27.9 27868 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
GH02I219683 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.6 +144.0 144012 7.4 PKNOX1 ARID4B SIN3A ZNF143 RUNX3 SP3 CAVIN1 GTF2B NFYC REST OBSL1 CHPF TMEM198 ENSG00000228973 SLC4A3 DNPEP DNAJB2 ATG9A GC02M219685 LOC105373886
GH02I219438 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10.3 -100.3 -100340 9.5 PKNOX1 ZFP64 BMI1 ZNF335 GLIS2 EGR1 EGR2 ZBTB11 ZC3H11A ZNF398 CNOT9 STK36 USP37 BCS1L ASIC4 ANKZF1 GMPPA DES ENSG00000272644 ENSG00000227432
GH02I219520 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -21.6 -21639 3.5 HDGF PKNOX1 ATF1 ARNT ETS1 GTF3C2 TCF12 ZNF766 GLIS2 GATA2 ASIC4 TMEM198 ENSG00000269068 LOC105373885
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM198 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM198 gene promoter:

Genomic Locations for TMEM198 Gene

Genomic Locations for TMEM198 Gene
6,933 bases
Plus strand

Genomic View for TMEM198 Gene

Genes around TMEM198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM198 Gene

Proteins for TMEM198 Gene

  • Protein details for TMEM198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 198
    Protein Accession:

    Protein attributes for TMEM198 Gene

    360 amino acids
    Molecular mass:
    39475 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for TMEM198 Gene

Post-translational modifications for TMEM198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM198 Gene

No data available for DME Specific Peptides for TMEM198 Gene

Domains & Families for TMEM198 Gene

Gene Families for TMEM198 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM198 Gene


Suggested Antigen Peptide Sequences for TMEM198 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM198 family.
  • Belongs to the TMEM198 family.
genes like me logo Genes that share domains with TMEM198: view

Function for TMEM198 Gene

Molecular function for TMEM198 Gene

UniProtKB/Swiss-Prot Function:
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

Phenotypes for TMEM198 Gene

GenomeRNAi human phenotypes for TMEM198:
genes like me logo Genes that share phenotypes with TMEM198: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM198 Gene

Localization for TMEM198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM198 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM198 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21536646
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IDA,IEA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

Pathways & Interactions for TMEM198 Gene

SuperPathways for TMEM198 Gene

No Data Available

Interacting Proteins for TMEM198 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000343507 for TMEM198 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM198 Gene

Drugs & Compounds for TMEM198 Gene

No Compound Related Data Available

Transcripts for TMEM198 Gene

Unigene Clusters for TMEM198 Gene

Transmembrane protein 198:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM198 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP2: -
SP3: -

Relevant External Links for TMEM198 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM198 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM198 Gene

Protein differential expression in normal tissues from HIPED for TMEM198 Gene

This gene is overexpressed in Lung (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM198 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM198 Gene:


SOURCE GeneReport for Unigene cluster for TMEM198 Gene:


Evidence on tissue expression from TISSUES for TMEM198 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM198: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM198 Gene

Orthologs for TMEM198 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM198 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM198 33 34
  • 99.63 (n)
(Bos Taurus)
Mammalia TMEM198 34
  • 97 (a)
(Canis familiaris)
Mammalia TMEM198 33 34
  • 91.57 (n)
(Mus musculus)
Mammalia Tmem198 33 16 34
  • 90.28 (n)
(Rattus norvegicus)
Mammalia Tmem198 33
  • 89.91 (n)
(Monodelphis domestica)
Mammalia TMEM198 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM198 34
  • 53 (a)
(Gallus gallus)
Aves TMEM198 33 34
  • 69.01 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem198 33
  • 57.72 (n)
Str.5257 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29730 33
(Danio rerio)
Actinopterygii tmem198b 33
  • 62.37 (n)
tmem198a 34
  • 53 (a)
Dr.7471 33
fruit fly
(Drosophila melanogaster)
Insecta CG14234 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4659 34
  • 44 (a)
Species where no ortholog for TMEM198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM198 Gene

Gene Tree for TMEM198 (if available)
Gene Tree for TMEM198 (if available)

Paralogs for TMEM198 Gene Pseudogenes for TMEM198 Gene

genes like me logo Genes that share paralogs with TMEM198: view

No data available for Paralogs for TMEM198 Gene

Variants for TMEM198 Gene

Sequence variations from dbSNP and Humsavar for TMEM198 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs538538342 uncertain-significance, Three M syndrome 219,550,733(+) T/TAT downstream_transcript_variant
rs1000457868 -- 219,544,407(+) G/T intron_variant
rs1000540037 -- 219,550,885(+) G/A/T downstream_transcript_variant
rs1001518587 -- 219,550,664(+) C/T downstream_transcript_variant
rs1001738725 -- 219,544,056(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM198 Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489
nsv520958 CNV loss 19592680
nsv584502 CNV gain 21841781
nsv821906 CNV gain 20364138
nsv834545 CNV loss 17160897

Variation tolerance for TMEM198 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM198 Gene

Disorders for TMEM198 Gene

Additional Disease Information for TMEM198

No disorders were found for TMEM198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM198 Gene

Publications for TMEM198 Gene

  1. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. (PMID: 21536646) Liang J … Wu W (Molecular and cellular biology 2011) 3 4 58
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM198 Gene

Sources for TMEM198 Gene

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