Aliases for TMEM198 Gene

Aliases for TMEM198 Gene

  • Transmembrane Protein 198 2 3 4 5
  • TMEM198A 2 3
  • MGC99813 2
  • TMEM198 5

External Ids for TMEM198 Gene

Previous GeneCards Identifiers for TMEM198 Gene

  • GC02P220117
  • GC02P220408
  • GC02P212261

Summaries for TMEM198 Gene

GeneCards Summary for TMEM198 Gene

TMEM198 (Transmembrane Protein 198) is a Protein Coding gene. Diseases associated with TMEM198 include Vitreoretinal Degeneration, Snowflake Type.

UniProtKB/Swiss-Prot Summary for TMEM198 Gene

  • Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM198 Gene

Genomics for TMEM198 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM198 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM198 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM198

Top Transcription factor binding sites by QIAGEN in the TMEM198 gene promoter:
  • HOXA3
  • HSF2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • Spz1
  • STAT5A

Genomic Locations for TMEM198 Gene

Latest Assembly
chr2:219,543,663-219,550,595
(GRCh38/hg38)
Size:
6,933 bases
Orientation:
Plus strand

Previous Assembly
chr2:220,408,385-220,415,317
(GRCh37/hg19 by Entrez Gene)
Size:
6,933 bases
Orientation:
Plus strand

chr2:220,408,385-220,415,317
(GRCh37/hg19 by Ensembl)
Size:
6,933 bases
Orientation:
Plus strand

Genomic View for TMEM198 Gene

Genes around TMEM198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM198 Gene

Proteins for TMEM198 Gene

  • Protein details for TMEM198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K66-TM198_HUMAN
    Recommended name:
    Transmembrane protein 198
    Protein Accession:
    Q66K66

    Protein attributes for TMEM198 Gene

    Size:
    360 amino acids
    Molecular mass:
    39475 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for TMEM198 Gene

Post-translational modifications for TMEM198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM198 Gene

No data available for DME Specific Peptides for TMEM198 Gene

Domains & Families for TMEM198 Gene

Gene Families for TMEM198 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM198 Gene

InterPro:

Suggested Antigen Peptide Sequences for TMEM198 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 198 (TM198_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q66K66

UniProtKB/Swiss-Prot:

TM198_HUMAN :
  • Belongs to the TMEM198 family.
Family:
  • Belongs to the TMEM198 family.
genes like me logo Genes that share domains with TMEM198: view

Function for TMEM198 Gene

Molecular function for TMEM198 Gene

UniProtKB/Swiss-Prot Function:
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

Phenotypes From GWAS Catalog for TMEM198 Gene

genes like me logo Genes that share phenotypes with TMEM198: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM198

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM198 Gene

Localization for TMEM198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM198 Gene

Membrane. Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM198 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,IDA 21536646
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IBA,IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

Pathways & Interactions for TMEM198 Gene

PathCards logo

SuperPathways for TMEM198 Gene

No Data Available

Interacting Proteins for TMEM198 Gene

Gene Ontology (GO) - Biological Process for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway IEA,IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM198 Gene

Drugs & Compounds for TMEM198 Gene

No Compound Related Data Available

Transcripts for TMEM198 Gene

mRNA/cDNA for TMEM198 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM198

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM198 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for TMEM198 Gene

GeneLoc Exon Structure for
TMEM198

Expression for TMEM198 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM198 Gene

Protein differential expression in normal tissues from HIPED for TMEM198 Gene

This gene is overexpressed in Lung (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM198 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM198

SOURCE GeneReport for Unigene cluster for TMEM198 Gene:

Hs.446664

Evidence on tissue expression from TISSUES for TMEM198 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM198: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM198 Gene

Orthologs for TMEM198 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM198 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM198 29 30
  • 99.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM198 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM198 29 30
  • 91.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem198 29 16 30
  • 90.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem198 29
  • 89.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM198 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM198 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM198 29 30
  • 69.01 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem198 29
  • 57.72 (n)
Str.5257 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.29730 29
Zebrafish
(Danio rerio)
Actinopterygii tmem198b 29
  • 62.37 (n)
tmem198a 30
  • 53 (a)
OneToMany
Dr.7471 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG14234 30
  • 20 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4659 30
  • 44 (a)
OneToOne
Species where no ortholog for TMEM198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM198 Gene

ENSEMBL:
Gene Tree for TMEM198 (if available)
TreeFam:
Gene Tree for TMEM198 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM198: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM198

Paralogs for TMEM198 Gene

Pseudogenes.org Pseudogenes for TMEM198 Gene

genes like me logo Genes that share paralogs with TMEM198: view

No data available for Paralogs for TMEM198 Gene

Variants for TMEM198 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM198 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM198 Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489
nsv520958 CNV loss 19592680
nsv584502 CNV gain 21841781
nsv821906 CNV gain 20364138
nsv834545 CNV loss 17160897

Variation tolerance for TMEM198 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM198
Leiden Open Variation Database (LOVD)
TMEM198

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM198 Gene

Disorders for TMEM198 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM198 Gene - From: COP

Disorder Aliases PubMed IDs
vitreoretinal degeneration, snowflake type
  • svd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM198

genes like me logo Genes that share disorders with TMEM198: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM198 Gene

Publications for TMEM198 Gene

  1. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. (PMID: 21536646) Liang J … Wu W (Molecular and cellular biology 2011) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMEM198 Gene

Sources for TMEM198 Gene