Aliases for TMEM192 Gene

Aliases for TMEM192 Gene

  • Transmembrane Protein 192 2 3 4 5
  • FLJ38482 2
  • TMEM192 5

External Ids for TMEM192 Gene

Previous GeneCards Identifiers for TMEM192 Gene

  • GC04M166219
  • GC04M165997
  • GC04M161750

Summaries for TMEM192 Gene

GeneCards Summary for TMEM192 Gene

TMEM192 (Transmembrane Protein 192) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

Additional gene information for TMEM192 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM192 Gene

Genomics for TMEM192 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM192 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J165111 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 617.9 +95.8 95778 2.7 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 IKZF1 TMEM192 KLHL2 TLL1 piR-47162-115 lnc-TRIM75P-3 TRIM60
GH04J165206 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.5 548 3.6 RNF2 PRDM10 LARP7 RBFOX2 POLR2A REST EZH2 YY1 ZNF341 PKNOX1 KLHL2 TMEM192
GH04J165323 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -119.6 -119591 10.1 BRCA1 SP1 CREB1 GATAD2A HNRNPL REST TFE3 RFX1 SOX13 IKZF1 MSMO1 lnc-GK3P-6 KLHL2 TMEM192 NACA3P MIR578 RPL21P51 CPE LOC105377519
GH04J165251 Enhancer 0.9 Ensembl ENCODE 12.4 -49.6 -49552 12.6 IKZF2 CEBPA SOX13 ARID3A TCF7 PAX8 DPF2 NFE2 ZNF316 MAFG KLHL2 TMEM192 MSMO1 L13713-173 RNU4-87P RF00015-056 piR-55194-282
GH04J165132 Enhancer 0.8 Ensembl ENCODE 11.9 +75.5 75548 3.6 CTCF JUND ZNF143 REST RAD21 TRIM22 PKNOX1 ZNF316 SMC3 MAFG KLHL2 TMEM192 MSMO1 MIR578 piR-38920-014 piR-35674-402 TRIM60
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM192 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM192

Top Transcription factor binding sites by QIAGEN in the TMEM192 gene promoter:
  • FOXO4
  • HSF1 (long)
  • HSF1short
  • HSF2

Genomic Locations for TMEM192 Gene

Genomic Locations for TMEM192 Gene
137,942 bases
Minus strand
134,128 bases
Minus strand

Genomic View for TMEM192 Gene

Genes around TMEM192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM192 Gene

Proteins for TMEM192 Gene

  • Protein details for TMEM192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 192
    Protein Accession:
    Secondary Accessions:
    • Q7Z3A1
    • Q8N928

    Protein attributes for TMEM192 Gene

    271 amino acids
    Molecular mass:
    30922 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=CAD97974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM192 Gene


neXtProt entry for TMEM192 Gene

Post-translational modifications for TMEM192 Gene

Other Protein References for TMEM192 Gene

No data available for DME Specific Peptides for TMEM192 Gene

Domains & Families for TMEM192 Gene

Gene Families for TMEM192 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM192 Gene


Suggested Antigen Peptide Sequences for TMEM192 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 192 (TM192_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM192 family.
  • Belongs to the TMEM192 family.
genes like me logo Genes that share domains with TMEM192: view

Function for TMEM192 Gene

Phenotypes From GWAS Catalog for TMEM192 Gene

Gene Ontology (GO) - Molecular Function for TMEM192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 20370317
genes like me logo Genes that share ontologies with TMEM192: view
genes like me logo Genes that share phenotypes with TMEM192: view

Animal Models for TMEM192 Gene

MGI Knock Outs for TMEM192:
  • Tmem192 Tmem192<tm2d(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM192

CRISPR Products

miRNA for TMEM192 Gene

miRTarBase miRNAs that target TMEM192

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM192 Gene

Localization for TMEM192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM192 Gene

Lysosome membrane. Multi-pass membrane protein. Late endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM192 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 4
nucleus 4
cytosol 2
golgi apparatus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endosomes (3)
  • Lysosomes (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 22736246
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA,IDA 22736246
GO:0005765 lysosomal membrane IBA,IDA 20370317
GO:0005768 endosome IDA --
genes like me logo Genes that share ontologies with TMEM192: view

Pathways & Interactions for TMEM192 Gene

PathCards logo

SuperPathways for TMEM192 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM192 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM192 Gene

Drugs & Compounds for TMEM192 Gene

No Compound Related Data Available

Transcripts for TMEM192 Gene

mRNA/cDNA for TMEM192 Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM192

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM192 Gene

No ASD Table

Relevant External Links for TMEM192 Gene

GeneLoc Exon Structure for

Expression for TMEM192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM192 Gene

Protein differential expression in normal tissues from HIPED for TMEM192 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Bone (8.2), and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM192 Gene

Protein tissue co-expression partners for TMEM192 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM192

SOURCE GeneReport for Unigene cluster for TMEM192 Gene:


mRNA Expression by UniProt/SwissProt for TMEM192 Gene:

Tissue specificity: Strongly expressed in kidney, liver, lung and pancreas.

Evidence on tissue expression from TISSUES for TMEM192 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Skin(4.3)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with TMEM192: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM192 Gene

Orthologs for TMEM192 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM192 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM192 30 31
  • 99.51 (n)
(Bos Taurus)
Mammalia TMEM192 30 31
  • 83.4 (n)
(Canis familiaris)
Mammalia TMEM192 30 31
  • 83.27 (n)
(Mus musculus)
Mammalia Tmem192 30 17 31
  • 82.08 (n)
(Rattus norvegicus)
Mammalia Tmem192 30
  • 81.45 (n)
(Monodelphis domestica)
Mammalia TMEM192 31
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM192 31
  • 71 (a)
(Gallus gallus)
Aves TMEM192 31
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 70 (a)
-- 31
  • 60 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem192 30
  • 58.24 (n)
(Danio rerio)
Actinopterygii tmem192 30 31
  • 49.14 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7523 31
  • 21 (a)
Species where no ortholog for TMEM192 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM192 Gene

Gene Tree for TMEM192 (if available)
Gene Tree for TMEM192 (if available)
Evolutionary constrained regions (ECRs) for TMEM192: view image

Paralogs for TMEM192 Gene Pseudogenes for TMEM192 Gene

genes like me logo Genes that share paralogs with TMEM192: view

No data available for Paralogs for TMEM192 Gene

Variants for TMEM192 Gene

Additional dbSNP identifiers (rs#s) for TMEM192 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM192 Gene

Variant ID Type Subtype PubMed ID
dgv132e180 CNV gain 20482838
dgv154n73 CNV deletion 24416366
dgv2932n106 CNV deletion 24896259
dgv908n67 CNV loss 20364138
dgv9369n54 CNV gain 21841781
esv1000719 CNV deletion 20482838
esv22270 CNV gain 19812545
esv2558277 CNV deletion 19546169
esv2728686 CNV deletion 23290073
esv3297717 CNV deletion 24192839
esv3564938 CNV deletion 23714750
esv3569802 CNV loss 25503493
esv3603015 CNV loss 21293372
nsv1071620 CNV deletion 25765185
nsv1131840 CNV deletion 24896259
nsv1149241 CNV deletion 26484159
nsv507211 OTHER sequence alteration 20534489
nsv511271 CNV loss 21212237
nsv513175 CNV loss 21212237
nsv518959 CNV loss 19592680
nsv596041 CNV gain+loss 21841781
nsv596042 CNV gain+loss 21841781
nsv596043 CNV loss 21841781
nsv596046 CNV gain 21841781
nsv820721 CNV deletion 20802225
nsv980162 CNV deletion 23825009

Variation tolerance for TMEM192 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM192 Gene

Disorders for TMEM192 Gene

No disorders were found for TMEM192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM192 Gene

Publications for TMEM192 Gene

  1. Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. (PMID: 20370317) Schröder B … Saftig P (Biological chemistry 2010) 2 3 4
  2. Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. (PMID: 21143193) Behnke J … Schröder B (The Biochemical journal 2011) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. (PMID: 28675297) Kumar P … Maddika S (Journal of proteome research 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for TMEM192 Gene

Sources for TMEM192 Gene