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Aliases for TMEM191C Gene

Aliases for TMEM191C Gene

  • Transmembrane Protein 191C 2 3 5
  • KB-1323B2.6 3

External Ids for TMEM191C Gene

Previous GeneCards Identifiers for TMEM191C Gene

  • GC22P020151
  • GC22P021821
  • GC22P021825
  • GC22P021469
  • GC22P021500
  • GC22P021542
  • GC22P021843
  • GC22P021870
  • GC22P021906
  • GC22P021942

Summaries for TMEM191C Gene

GeneCards Summary for TMEM191C Gene

TMEM191C (Transmembrane Protein 191C) is a Protein Coding gene. An important paralog of this gene is TMEM191B.

Additional gene information for TMEM191C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM191C Gene

Genomics for TMEM191C Gene

GeneHancer (GH) Regulatory Elements for TMEM191C Gene

Promoters and enhancers for TMEM191C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I021467 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 +1.7 1678 1.8 HDAC1 PKNOX1 RB1 ZBTB40 EGR1 ATF7 SP3 ZBTB11 NCOA1 ELF1 TMEM191C GC22P022014 CCDC116 LZTR1 PI4KAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM191C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM191C gene promoter:

Genomic Locations for TMEM191C Gene

Genomic Locations for TMEM191C Gene
chr22:21,466,423-21,471,269
(GRCh38/hg38)
Size:
4,847 bases
Orientation:
Plus strand
chr22:21,820,712-21,825,558
(GRCh37/hg19)

Genomic View for TMEM191C Gene

Genes around TMEM191C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM191C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM191C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM191C Gene

Proteins for TMEM191C Gene

  • Protein details for TMEM191C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGB0-T191C_HUMAN
    Recommended name:
    Transmembrane protein 191C
    Protein Accession:
    A6NGB0

    Protein attributes for TMEM191C Gene

    Size:
    347 amino acids
    Molecular mass:
    39292 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM191C Gene

Post-translational modifications for TMEM191C Gene

No Post-translational modifications

Other Protein References for TMEM191C Gene

No data available for DME Specific Peptides for TMEM191C Gene

Domains & Families for TMEM191C Gene

Gene Families for TMEM191C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM191C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM191C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGB0

UniProtKB/Swiss-Prot:

T191C_HUMAN :
  • Belongs to the TMEM191 family.
Family:
  • Belongs to the TMEM191 family.
genes like me logo Genes that share domains with TMEM191C: view

Function for TMEM191C Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM191C Gene

Localization for TMEM191C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM191C Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM191C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM191C: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM191C Gene

Pathways & Interactions for TMEM191C Gene

SuperPathways for TMEM191C Gene

No Data Available

Interacting Proteins for TMEM191C Gene

Gene Ontology (GO) - Biological Process for TMEM191C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM191C Gene

Drugs & Compounds for TMEM191C Gene

No Compound Related Data Available

Transcripts for TMEM191C Gene

mRNA/cDNA for TMEM191C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM191C Gene

Transmembrane protein 191C:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM191C Gene

No ASD Table

Relevant External Links for TMEM191C Gene

GeneLoc Exon Structure for
TMEM191C
ECgene alternative splicing isoforms for
TMEM191C

Expression for TMEM191C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM191C Gene

mRNA differential expression in normal tissues according to GTEx for TMEM191C Gene

This gene is overexpressed in Testis (x11.7).

Protein differential expression in normal tissues from HIPED for TMEM191C Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM191C Gene



Protein tissue co-expression partners for TMEM191C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM191C Gene:

TMEM191C

SOURCE GeneReport for Unigene cluster for TMEM191C Gene:

Hs.376511
genes like me logo Genes that share expression patterns with TMEM191C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM191C Gene

Orthologs for TMEM191C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM191C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM191C 33
  • 96.83 (n)
Species where no ortholog for TMEM191C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM191C Gene

ENSEMBL:
Gene Tree for TMEM191C (if available)
TreeFam:
Gene Tree for TMEM191C (if available)

Paralogs for TMEM191C Gene

Paralogs for TMEM191C Gene

genes like me logo Genes that share paralogs with TMEM191C: view

Variants for TMEM191C Gene

Sequence variations from dbSNP and Humsavar for TMEM191C Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000987912 -- 21,468,339(+) A/G intron_variant
rs1001199963 -- 21,470,381(+) TTTTCTTTTCTTT/TTTTCTTT downstream_transcript_variant
rs1001274387 -- 21,468,890(+) G/A intron_variant
rs1001713302 -- 21,469,847(+) G/A 3_prime_UTR_variant
rs1003374368 -- 21,465,216(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM191C Gene

Variant ID Type Subtype PubMed ID
nsv953042 CNV deletion 24416366
nsv834145 CNV loss 17160897
nsv7350 OTHER inversion 18451855
nsv511071 OTHER inversion 20534489
nsv471596 CNV gain+loss 15918152
nsv469545 CNV gain 16826518
nsv442791 CNV gain 18776908
nsv436864 CNV insertion 17901297
nsv428386 CNV loss 18775914
nsv1160730 CNV deletion 26073780
nsv1160729 CNV duplication 26073780
nsv1118947 CNV deletion 24896259
nsv1073155 CNV deletion 25765185
nsv1066391 CNV gain 25217958
esv3893444 CNV gain 25118596
esv3584494 CNV gain 24956385
esv2763699 CNV gain+loss 21179565
esv2760719 CNV gain 21179565
esv2678291 CNV deletion 23128226
esv25508 CNV gain+loss 19812545
dgv4491n100 CNV gain 25217958
dgv4490n100 CNV gain 25217958
dgv4489n100 CNV gain 25217958
dgv4488n100 CNV gain 25217958
dgv4487n100 CNV gain 25217958
dgv4486n100 CNV gain 25217958

Additional Variant Information for TMEM191C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM191C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TMEM191C Gene

Disorders for TMEM191C Gene

Additional Disease Information for TMEM191C

No disorders were found for TMEM191C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM191C Gene

Publications for TMEM191C Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58

Products for TMEM191C Gene

Sources for TMEM191C Gene

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