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Aliases for TMEM191B Gene

Aliases for TMEM191B Gene

  • Transmembrane Protein 191B 2 3 5

External Ids for TMEM191B Gene

Previous GeneCards Identifiers for TMEM191B Gene

  • GC22P018757
  • GC22P020379
  • GC22P004856
  • GC22P020381
  • GC22P020383

Summaries for TMEM191B Gene

GeneCards Summary for TMEM191B Gene

TMEM191B (Transmembrane Protein 191B) is a Protein Coding gene. An important paralog of this gene is TMEM191C.

Additional gene information for TMEM191B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM191B Gene

Genomics for TMEM191B Gene

GeneHancer (GH) Regulatory Elements for TMEM191B Gene

Promoters and enhancers for TMEM191B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I018527 Promoter/Enhancer 1.2 Ensembl ENCODE 550.8 +1.0 1010 2 ZNF639 MAZ ZBTB6 RB1 ZBTB11 NRF1 SP2 ZNF335 CTBP1 ZNF341 ENSG00000277690 LOC100996401 TMEM191B PI4KAP1
GH22I018576 Promoter 0.6 Ensembl 0.2 +50.0 49999 2 EGR1 PI4KAP1 TMEM191B
GH22I018552 Enhancer 0.3 Ensembl 0.3 +26.1 26099 2.6 NFIB PI4KAP1 TMEM191B
GH22I018548 Enhancer 0.2 Ensembl 0.3 +20.5 20499 0.2 TMEM191B PI4KAP1
GH22I018557 Enhancer 0.2 Ensembl 0.3 +31.3 31299 3.8 PI4KAP1 TMEM191B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM191B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM191B gene promoter:

Genomic Locations for TMEM191B Gene

Genomic Locations for TMEM191B Gene
chr22:18,527,802-18,530,794
(GRCh38/hg38)
Size:
2,993 bases
Orientation:
Plus strand
chr22:20,377,669-20,380,440
(GRCh37/hg19)

Genomic View for TMEM191B Gene

Genes around TMEM191B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM191B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM191B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM191B Gene

Proteins for TMEM191B Gene

  • Protein details for TMEM191B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7N4-T191B_HUMAN
    Recommended name:
    Transmembrane protein 191B
    Protein Accession:
    P0C7N4
    Secondary Accessions:
    • A0A087WXW8

    Protein attributes for TMEM191B Gene

    Size:
    346 amino acids
    Molecular mass:
    39065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM191B Gene

Post-translational modifications for TMEM191B Gene

No Post-translational modifications

Other Protein References for TMEM191B Gene

No data available for DME Specific Peptides for TMEM191B Gene

Domains & Families for TMEM191B Gene

Gene Families for TMEM191B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM191B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM191B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7N4

UniProtKB/Swiss-Prot:

T191B_HUMAN :
  • Belongs to the TMEM191 family.
Family:
  • Belongs to the TMEM191 family.
genes like me logo Genes that share domains with TMEM191B: view

Function for TMEM191B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM191B Gene

Localization for TMEM191B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM191B Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM191B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM191B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM191B Gene

Pathways & Interactions for TMEM191B Gene

SuperPathways for TMEM191B Gene

No Data Available

Interacting Proteins for TMEM191B Gene

Gene Ontology (GO) - Biological Process for TMEM191B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM191B Gene

Drugs & Compounds for TMEM191B Gene

No Compound Related Data Available

Transcripts for TMEM191B Gene

mRNA/cDNA for TMEM191B Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM191B Gene

No ASD Table

Relevant External Links for TMEM191B Gene

GeneLoc Exon Structure for
TMEM191B
ECgene alternative splicing isoforms for
TMEM191B

Expression for TMEM191B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM191B Gene:

TMEM191B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM191B Gene

Orthologs for TMEM191B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM191B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM191C 33
  • 97.21 (n)
Species where no ortholog for TMEM191B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM191B Gene

ENSEMBL:
Gene Tree for TMEM191B (if available)
TreeFam:
Gene Tree for TMEM191B (if available)

Paralogs for TMEM191B Gene

Paralogs for TMEM191B Gene

(1) SIMAP similar genes for TMEM191B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM191B Gene

genes like me logo Genes that share paralogs with TMEM191B: view

Variants for TMEM191B Gene

Sequence variations from dbSNP and Humsavar for TMEM191B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000506001 -- 18,527,221(+) G/A upstream_transcript_variant
rs1002176803 -- 18,530,677(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1002312421 -- 18,530,046(+) G/A/T intron_variant
rs1005878171 -- 18,528,135(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1006586266 -- 18,528,788(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM191B Gene

Variant ID Type Subtype PubMed ID
nsv428385 CNV gain+loss 18775914
nsv1146969 CNV duplication 26484159
nsv1144015 CNV deletion 24896259
nsv1071779 CNV deletion 25765185
nsv1061694 CNV gain 25217958
nsv1055756 CNV gain 25217958
esv3575418 CNV gain 25503493
esv3381183 CNV duplication 20981092
esv32687 CNV gain+loss 17666407
esv2758824 CNV gain+loss 17122850
esv2751935 CNV loss 17911159
esv26930 CNV gain+loss 19812545
esv22247 CNV gain+loss 19812545
dgv99e203 CNV gain+loss 21179565
dgv7990n54 CNV gain 21841781
dgv7989n54 CNV gain 21841781
dgv7988n54 CNV gain 21841781
dgv7987n54 CNV gain 21841781
dgv7965n54 CNV gain 21841781
dgv7964n54 CNV loss 21841781
dgv7963n54 CNV gain 21841781
dgv4467n100 CNV gain 25217958
dgv4466n100 CNV gain+loss 25217958
dgv2431n106 OTHER inversion 24896259
dgv173e55 CNV gain 17911159
dgv16n31 CNV gain 19718026
dgv1283e212 CNV gain 25503493
nsv962755 CNV duplication 23825009
nsv953028 CNV deletion 24416366
nsv820540 CNV duplication 20802225
nsv588264 CNV loss 21841781
nsv588139 CNV loss 21841781
nsv516997 CNV gain+loss 19592680
nsv511636 CNV loss 21212237
nsv471594 CNV gain+loss 15918152
nsv471339 CNV gain 19718026
nsv469578 CNV gain 16826518

Additional Variant Information for TMEM191B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM191B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TMEM191B Gene

Disorders for TMEM191B Gene

Additional Disease Information for TMEM191B

No disorders were found for TMEM191B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM191B Gene

Publications for TMEM191B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for TMEM191B Gene

Sources for TMEM191B Gene

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