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Aliases for TMEM191B Gene
External Ids for TMEM191B Gene
- HGNC: 33600
- Entrez Gene: 728229
- Ensembl: ENSG00000278558
- UniProtKB: P0C7N4
Previous GeneCards Identifiers for TMEM191B Gene
- GC22P018757
- GC22P020379
- GC22P004856
- GC22P020381
- GC22P020383
Summaries for TMEM191B Gene
GeneCards Summary for TMEM191B Gene
TMEM191B (Transmembrane Protein 191B) is a Protein Coding gene. An important paralog of this gene is TMEM191C.
Additional gene information for TMEM191B Gene
- HGNC(33600)
- Entrez Gene(728229)
- Ensembl(ENSG00000278558)
- UniProtKB(P0C7N4)
- Open Targets Platform(ENSG00000278558)
- Search for TMEM191B at DataMed
- Search for TMEM191B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM191B Gene
Genomics for TMEM191B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMEM191B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22J018527 | Promoter/Enhancer | 1 | Ensembl ENCODE | 600.7 | +1.3 | 1299 | 3.4 | PRDM10 ZNF341 KLF9 SP2 EGR1 CTBP1 ZBTB40 CREB1 ZBTB26 ZBTB17 | ENSG00000277690 NONHSAG033313.2 TMEM191B lnc-GGTLC3-2 RIMBP3 | |
| GH22J018572 | Promoter | 0.8 | Ensembl | 0.3 | +48.0 | 47999 | 6.4 | ARHGAP35 MTA2 YBX3 NKRF POLR2A EGR1 HDGF GATAD2A TRIM25 DPF2 | UFD1 PI4KAP1 lnc-GGTLC3-4 piR-57460-432 RIMBP3 TMEM191B | |
| GH22J018552 | Promoter | 0.3 | Ensembl | 0.3 | +25.5 | 25499 | 0.2 | lnc-TMEM191B-5 piR-57460-432 PI4KAP1 lnc-GGTLC3-4 TMEM191B RIMBP3 | ||
| GH22J018549 | Enhancer | 0.3 | Ensembl | 0.4 | +22.2 | 22160 | 0.9 | NFIC | lnc-TMEM191B-5 lnc-GGTLC3-2 TMEM191B PI4KAP1 lnc-GGTLC3-4 RIMBP3 | |
| GH22J018557 | Promoter | 0.3 | Ensembl | 0.3 | +30.4 | 30399 | 0.4 | piR-57460-432 lnc-TMEM191B-5 lnc-GGTLC3-4 PI4KAP1 TMEM191B RIMBP3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMEM191B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM191B
- Top Transcription factor binding sites by QIAGEN in the TMEM191B gene promoter:
-
- AREB6
- E47
- GCNF
- GCNF-1
- GCNF-2
- LUN-1
- NRSF form 1
- NRSF form 2
- Pax-6
- Pbx1a
Genomic Locations for TMEM191B Gene
Genomic Locations for TMEM191B Gene
- chr22:18,527,802-18,531,920
- (GRCh38/hg38)
- Size:
- 4,119 bases
- Orientation:
- Plus strand
- chr22:20,377,669-20,380,440
- (GRCh37/hg19)
- Size:
- 2,772 bases
- Orientation:
- Plus strand
Genomic View for TMEM191B Gene
Genes around TMEM191B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
TMEM191B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM191B Gene
Proteins for TMEM191B Gene
-
Protein details for TMEM191B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C7N4-T191B_HUMAN
- Recommended name:
- Transmembrane protein 191B
- Protein Accession:
- P0C7N4
- A0A087WXW8
Protein attributes for TMEM191B Gene
- Size:
- 346 amino acids
- Molecular mass:
- 39065 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TMEM191B Gene
Other Protein References for TMEM191B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM191B
- Origene Custom Protein Services for TMEM191B
No data available for DME Specific Peptides for TMEM191B Gene
Domains & Families for TMEM191B Gene
Gene Families for TMEM191B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TMEM191B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM191B Gene
- GenScript: Design optimal peptide antigens:
-
- Transmembrane protein 191B (T191B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0C7N4- Family:
-
- Belongs to the TMEM191 family.
Function for TMEM191B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM191B - Select products 50% OFF >
- * TMEM191B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM191B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM191B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM191B
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM191B
Clone Products
- Applied Biological Materials (abm): Clones for TMEM191B - Select products 50% OFF >
- * TMEM191B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM191B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM191B
Cell Line Products
-
Horizon Cell Lines for TMEM191B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM191B Gene
Localization for TMEM191B Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM191B Gene
- Membrane. Single-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM191B Gene
Transcripts for TMEM191B Gene
mRNA/cDNA for TMEM191B Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000612978 1334 nts (view in UCSC)
- ENST00000613577 354 nts (view in UCSC)
- ENST00000613597 366 nts (view in UCSC)
- ENST00000614395 1886 nts (view in UCSC)
- ENST00000618859 788 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM191B - Select products 50% OFF >
- * TMEM191B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM191B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM191B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM191B
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM191B
Clone Products
- Applied Biological Materials (abm): Clones for TMEM191B - Select products 50% OFF >
- * TMEM191B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM191B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM191B
Relevant External Links for TMEM191B Gene
- GeneLoc Exon Structure for
- TMEM191B
Expression for TMEM191B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM191B
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM191B Gene
Orthologs for TMEM191B Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMEM191C 30 |
|
- Species where no ortholog for TMEM191B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for TMEM191B Gene
- ENSEMBL:
- Gene Tree for TMEM191B (if available)
- TreeFam:
- Gene Tree for TMEM191B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM191B: view image
Paralogs for TMEM191B Gene
(1) SIMAP similar genes for TMEM191B Gene using alignment to 1 proteins:
- T191B_HUMAN
Pseudogenes.org Pseudogenes for TMEM191B Gene
Variants for TMEM191B Gene
Additional Variant Information for TMEM191B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM191B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TMEM191B Gene
Disorders for TMEM191B Gene
Additional Disease Information for TMEM191B
No disorders were found for TMEM191B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM191B Gene
Publications for TMEM191B Gene
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
ExternalLinks
Products for TMEM191B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM191B
- Origene Custom Protein Services for TMEM191B
- Browse OriGene Inhibitory RNA Products For TMEM191B
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for TMEM191B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMEM191B
- Sino Biological Human cDNA Clone for TMEM191B
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for TMEM191B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMEM191B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMEM191B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMEM191B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMEM191B
- Horizon Cell Lines for TMEM191B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM191B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM191B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMEM191B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM191B
Sources for TMEM191B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB