Aliases for TMEM190 Gene

Aliases for TMEM190 Gene

  • Transmembrane Protein 190 2 3 4 5
  • MDAC1 2 3 4
  • TMEM190 5

External Ids for TMEM190 Gene

Previous GeneCards Identifiers for TMEM190 Gene

  • GC19P060581
  • GC19P055888
  • GC19P052210

Summaries for TMEM190 Gene

GeneCards Summary for TMEM190 Gene

TMEM190 (Transmembrane Protein 190) is a Protein Coding gene. Diseases associated with TMEM190 include Brooke-Spiegler Syndrome. Gene Ontology (GO) annotations related to this gene include protein self-association.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM190 Gene

Genomics for TMEM190 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM190 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM190 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM190

Top Transcription factor binding sites by QIAGEN in the TMEM190 gene promoter:
  • AML1a
  • HEN1
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for TMEM190 Gene

Latest Assembly
chr19:55,376,126-55,378,246
(GRCh38/hg38)
Size:
2,121 bases
Orientation:
Plus strand

Previous Assembly
chr19:55,888,194-55,889,614
(GRCh37/hg19 by Entrez Gene)
Size:
1,421 bases
Orientation:
Plus strand

chr19:55,888,204-55,889,612
(GRCh37/hg19 by Ensembl)
Size:
1,409 bases
Orientation:
Plus strand

Genomic View for TMEM190 Gene

Genes around TMEM190 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM190 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM190 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM190 Gene

Proteins for TMEM190 Gene

  • Protein details for TMEM190 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ59-TM190_HUMAN
    Recommended name:
    Transmembrane protein 190
    Protein Accession:
    Q8WZ59
    Secondary Accessions:
    • A6NJL5

    Protein attributes for TMEM190 Gene

    Size:
    177 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM190 Gene

Post-translational modifications for TMEM190 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM190 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM190 Gene

Domains & Families for TMEM190 Gene

Gene Families for TMEM190 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM190 Gene

InterPro:
Blocks:
  • P-type trefoil domain

Suggested Antigen Peptide Sequences for TMEM190 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 190 (TM190_HUMAN)
genes like me logo Genes that share domains with TMEM190: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM190 Gene

Function for TMEM190 Gene

Phenotypes From GWAS Catalog for TMEM190 Gene

Gene Ontology (GO) - Molecular Function for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with TMEM190: view
genes like me logo Genes that share phenotypes with TMEM190: view

Animal Models for TMEM190 Gene

MGI Knock Outs for TMEM190:

miRNA for TMEM190 Gene

miRTarBase miRNAs that target TMEM190

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM190

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM190 Gene

Localization for TMEM190 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM190 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM190 gene
Compartment Confidence
nucleus 4
extracellular 3
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002079 inner acrosomal membrane IBA 21873635
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM190: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM190 Gene

Pathways & Interactions for TMEM190 Gene

PathCards logo

SuperPathways for TMEM190 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA,IBA 21873635
genes like me logo Genes that share ontologies with TMEM190: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM190 Gene

Drugs & Compounds for TMEM190 Gene

No Compound Related Data Available

Transcripts for TMEM190 Gene

mRNA/cDNA for TMEM190 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM190

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM190 Gene

No ASD Table

Relevant External Links for TMEM190 Gene

GeneLoc Exon Structure for
TMEM190

Expression for TMEM190 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM190 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TMEM190 Gene

This gene is overexpressed in Testis (x20.3), Fallopian Tube (x10.1), Cervix - Endocervix (x7.1), and Lung (x5.4).

Protein differential expression in normal tissues from HIPED for TMEM190 Gene

This gene is overexpressed in Testis (54.7) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM190 Gene



Protein tissue co-expression partners for TMEM190 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM190

SOURCE GeneReport for Unigene cluster for TMEM190 Gene:

Hs.590943
genes like me logo Genes that share expression patterns with TMEM190: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM190 Gene

Orthologs for TMEM190 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM190 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM190 29 30
  • 99.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM190 29 30
  • 81.02 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM190 29 30
  • 80.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem190 29 16 30
  • 75.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem190 29
  • 74.66 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM190 30
  • 43 (a)
OneToOne
Species where no ortholog for TMEM190 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMEM190 Gene

ENSEMBL:
Gene Tree for TMEM190 (if available)
TreeFam:
Gene Tree for TMEM190 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM190: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM190

Paralogs for TMEM190 Gene

No data available for Paralogs for TMEM190 Gene

Variants for TMEM190 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM190 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM190 Gene

Variant ID Type Subtype PubMed ID
esv2718965 CNV deletion 23290073
esv2718966 CNV deletion 23290073
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM190 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM190 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM190
Leiden Open Variation Database (LOVD)
TMEM190

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM190 Gene

Disorders for TMEM190 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM190 Gene - From: COP

Disorder Aliases PubMed IDs
brooke-spiegler syndrome
  • brss
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM190

genes like me logo Genes that share disorders with TMEM190: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM190 Gene

Publications for TMEM190 Gene

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. (PMID: 21273369) Nishimura H … Primakoff P (Reproduction (Cambridge, England) 2011) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3

Products for TMEM190 Gene

Sources for TMEM190 Gene